2022 American Transplant Congress
Achievement of Persistent Mixed Chimerism in Recipients of Matched and Mismatched Living Donor Kidney Transplants in a Tolerance Induction Protocol
Stanford University School of Medicine, Stanford, CA
*Purpose: The induction of tolerance to kidney transplants after development of specific unresponsiveness of recipient immune cells to donor alloantigens allows elimination of maintenance immunosuppressive…2022 American Transplant Congress
MTOR Inhibition Acts Directly on Endothelial Cells to Induce Contact-Independent Immune-Modulation of Allo-Specific T Cell Activation
Duke University School of Medicine, Durham, NC
*Purpose: Endothelial cells (ECs) form a barrier between vascularized organ allografts and host immunity and are known to provoke alloimmune responses. The mTOR inhibitor rapamycin…2022 American Transplant Congress
The Post-operative Clinical Outcomes Of 59 Tanrp Cases In An International Cohort
*Purpose: Heart transplantation is an immensely effective service and is currently the only definitive treatment for heart failure. However, transplantation is limited by donor availability.…2022 American Transplant Congress
Is a Single Dose of Steroids in Adult Living Donor Liver Transplant Safe? – A Cohort Analysis
University of California San Francisco, San Francisco, CA
*Purpose: Steroids increase morbidity, and steroid avoidance (SA) has been studied in deceased donor liver transplant but, little is known about SA in living donor…2022 American Transplant Congress
PTLD Suspected by Visualization of Atypical Urinary Lymphocytes
*Purpose: Urinalysis has been used for the detection of acute rejection but visualization of atypical lymphocytes in the urine sediment as an early sign of…2022 American Transplant Congress
Pd-1 Licenses Activated Treg for Lymphatic Migration
*Purpose: In addition to serving as fluid conduits, lymphatic vessels are critical portals for immune cell migration. Lymphatic endothelial cells (LECs) constitutively express high levels…2022 American Transplant Congress
Ex Vivo Modification of Vascular Allografts Using Immunosuppressive and Anti-Inflammatory Polymers Prevent Rejection via Localized Immunosuppression
*Purpose: Classical immunosuppressants lead to systemic immune shutdown, though necessary to mediate transplant rejection, it may lead to various complications. To reduce off-target immunosuppression while…2022 American Transplant Congress
Type 1 Innate Lymphoid Cells Are Critical Pro-Inflammatory Effector Cells in a Fatty Liver Mouse Model of Ischemia-Reperfusion Injury
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis through the production of key cytokine…2022 American Transplant Congress
Targeting the Bet Family Protein Brd4 Inhibits Inflammatory Macrophages and Promotes Heart Allograft Tolerance
Surgery, Houston Methodist Hospital, Houston, TX
*Purpose: Infiltration of allografts by inflammatory macrophages is frequently associated with chronic graft loss In both animal models and clinical settings, but the mechanisms that…2022 American Transplant Congress
Normothermic Machine Perfusion in Liver Transplantation – Seven Year Experience at a Single North American Centre
*Purpose: Machine perfusion for preservation of liver grafts before transplantation has risen in prominence over the past decade. Normothermic machine perfusion (NMP), in particular, has…
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