2022 American Transplant Congress
Targeting the Bet Family Protein Brd4 Inhibits Inflammatory Macrophages and Promotes Heart Allograft Tolerance
Surgery, Houston Methodist Hospital, Houston, TX
*Purpose: Infiltration of allografts by inflammatory macrophages is frequently associated with chronic graft loss In both animal models and clinical settings, but the mechanisms that…2022 American Transplant Congress
Better Antibody Response After a Dose of Ad.26.cov2.s vs MRNA Vaccines in Seronegative Transplant Recipients After 2-Dose MRNA Vaccination
1JHU, Baltimore, MD, 2U of Wisconsin, Madison, WI
*Purpose: To compare antibody response to a third dose (D3) of SARS-CoV-2 vaccine in solid organ transplant recipients (SOTRs) with negative or low-positive antibody levels…2022 American Transplant Congress
Establishment And Validation Of A Predictive Model For Differential Rejection Diagnosis By Gene Expression Profiling (GEP) In Renal Allograft Biopsies Using Banff Human Organ Transplant (B-HOT) Gene Panel
1CareDx, Inc., Brisbane, CA, 2Arkana Laboratories, Little Rock, AR
*Purpose: Large scale GEP studies evaluating the performance of Banff-endorsed B-HOT gene panel for allograft rejection diagnosis have not been published. In this study, we…2022 American Transplant Congress
FasL-Presenting PEG Microgels Supports Sustained Graft Survival in Nonhuman Primates in the Absence of Continuous Immunosuppression
*Purpose: Broad application of allogeneic islets for T1D treatment is curtailed by the use of chronic immunosuppression to control rejection. Teff cells are the major…2022 American Transplant Congress
Impact of a Pharmacist on Transitions and Ambulatory Outcomes in Lung Transplant Recipients
*Purpose: Minimal data exists describing the impact of a pharmacist in transitions of care (TOC) and ambulatory medication management in lung transplant recipients (LTRs). Following…2022 American Transplant Congress
Donor-Derived Cell-Free DNA as a Biomarker of T Cell Mediated Rejection in Pediatric Kidney Transplant Patients
*Purpose: T-cell-mediated rejection (TCMR) is a major cause of kidney allograft failure which requires kidney biopsy for a definitive diagnosis. Donor-derived cell-free DNA (dd-cfDNA) is…2022 American Transplant Congress
Desensitization Protocol to Prevent Severe Oliguric Antibody-Mediated Rejection
1Tokyo Womens, Tokyo 162-8666, Japan, 2Tokyo Women's Medical University, Tokyo, Japan
*Purpose: Antibody-mediated rejection in a case with a positive crossmatch test can be severe and result in sudden onset of oliguria and sometimes, anuria, leading…2022 American Transplant Congress
Rhesus-Primatized Mouse Model Generated Using Transgenic Immunodeficient Mice
1Surgery, University of Wisconsin, Madison, WI, 2University of Wisconsin, Madison, WI
*Purpose: To develop a translational primatized mouse model, akin to humanized mice, that allows for high-throughput in vivo experimentation to augment non-human primate pre-clinical studies.*Methods:…2022 American Transplant Congress
Focal Distribution of TCMR Causes False Negative Results in Spatially Resolved Molecular Diagnostic Assays
University of Pittsburgh, Pittsburgh, PA
*Purpose: Molecular assays on ~3mm biopsy (BX) fragments of cannot confirm histologic T-cell mediated rejection (TCMR) in ~50% of routine biopsies, and fail to detect…2022 American Transplant Congress
Assessment of the Prevalence of Burnout and Well-Being in Solid Organ Transplant Pharmacists
*Purpose: The purpose of this study was to determine the prevalence of burnout and well-being among solid organ transplant pharmacists in the United States.*Methods: A…
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