Abstracts Archive - Page 62 of 1683 - ATC Abstracts

2022 American Transplant Congress
First-in-Human Clinical-Grade Porcine Kidney Xenotransplant
J. E. Locke¹, B. Orandi¹, V. Kumar¹, J. Houp¹, D. Anderson¹, V. Hauptfeld¹, D. Martin², C. Killian¹, S. Macedon¹, N. Budd¹, K. Stegner¹, A. Dandro³, M. Kokkinaki³, K. Kuravi³, R. Reed⁴, H. Fatima¹, G. Baker¹, J. Perry¹, E. Bryant¹, M. Cheung¹, E. Erman¹, K. Kraebber¹, T. Gamblin¹, L. Guy¹, D. Ayares³, P. Porrett¹
¹University of Alabama at Birmingham, Birmingham, AL, ²Deakin University, Geelong, Australia, ³Revivicor, Incorporated, Blacksburg, VA, ⁴University of Alabama at Birmingham, Irondale, AL
*Purpose: Proof-of-concept xenotransplant work has been performed in pig to non-human primates (NHP), but it is unclear if outcomes can be recapitulated in humans. While…
2022 American Transplant Congress
Fibroblastic Reticular Cell Subset Transcriptional Reprogramming Differs in Response to Immunity versus Tolerance
L. Li¹, Y. Song¹, M. Shirkey¹, A. Kensiski¹, W. Piao¹, V. Saxena¹, S. Gavzy¹, B. Ma¹, R. Abdi², J. Bromberg¹
¹UMB, Baltimore, MD, ²Harvard University, Boston, MD
*Purpose: Lymph node (LN) fibroblastic reticular cells (FRCs) are central contributors to the LN niche. We hypothesized that FRC subsets reactive to immunity versus tolerance…
2022 American Transplant Congress
Long-Term Outcomes for Living Kidney Donors with Early Guideline-Concordant Follow-Up Care
A. Dhalla¹, A. Lloyd², K. L. Lentine³, A. X. Garg⁴, R. R. Quinn¹, P. Ravani¹, S. W. Klarenbach², B. R. Hemmelgarn², U. Ibelo¹, N. N. Lam¹
¹Department of Medicine, Division of Nephrology, University of Calgary, Calgary, AB, Canada, ²Department of Medicine, Division of Nephrology, University of Alberta, Edmonton, AB, Canada, ³Center for Abdominal Transplantation, Saint Louis University, St. Louis, MO, ⁴Department of Medicine, Division of Nephrology, Western University, London, ON, Canada
*Purpose: Current guidelines recommend that living kidney donors receive annual lifelong follow-up to monitor kidney health. It is unclear whether early guideline-concordant care is associated…
2022 American Transplant Congress
Donor Organ Utilization And Transplantation Outcomes In Donation After Circulatory Death Using Thoracoabdominal Normothermic Regional Perfusion
M. Urban, S. Merani, N. W. Markin, A. Castleberry, J. Um
University of Nebraska Medical Center, Omaha, NE
*Purpose: Evidence suggests that in-situ reperfusion of abdominal organs with normothermic oxygenated blood in donation after circulatory death (DCD) provides superior post-transplantation outcomes in comparison…
2022 American Transplant Congress
Disruption of B Cell Population is Associated with Increased Infections in Pediatric Transplant Recipients
B. Geng, L. Loop, C. Anterasian, D. Mortazavi, J. Kitsen, C. Collins, K. Newton, E. Ingulli
Pediatrics, UCSD Rady Children's, San Diego, CA
*Purpose: Solid-organ transplant recipients are placed on long-term immunosuppression, preventing graft rejection but increasing the risk of infection. Pediatric transplant recipients are at increased risk…
2022 American Transplant Congress
Public Acceptance of Living Donor Liver Transplant for Colorectal Liver Metastases: A National Survey
E. Pope-Collins, M. Nickels, K. Dokus, J. Martens, E. Keller, R. Hernandez-Alejandro, B. Al-Judaibi
University of Rochester, Rochester, NY
*Purpose: Recent advancements in cancer treatment and post-transplant management have allowed for a wider population of living donor transplant candidates. We employed a national survey…
2022 American Transplant Congress
The Gut Microbiome in the Critical Care Setting Post-Heart Transplantation
M. Dela Cruz¹, H. Lin², E. Adler², M. Khalid², J. Boissiere², G. Kim¹, S. Pinney¹, E. Pamer², A. Nguyen¹
¹Section of Cardiology, University of Chicago, Chicago, IL, ²Duchossois Family Institute, University of Chicago, Chicago, IL
*Purpose: Given its potential impact on immune activation and systemic inflammation, we aim to investigate gut microbiome compositions and metabolites during critical illness in the…
2022 American Transplant Congress
Patient-Reported Physical Function Correlates with Liver Frailty Index and 4-Meter Gait Speed in Patients with Cirrhosis
A. J. Thuluvath, J. Peipert, K. Belfanti, S. Morrissey, O. Siddiqui, J. Levitsky, Z. Dietch, A. Flores, D. P. Ladner
Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Frailty is highly prevalent in patients with end-stage liver disease and strongly predicts waitlist and post-transplant mortality. The Liver Frailty Index (LFI) and 4-meter…
2022 American Transplant Congress
Comparing Long-Term Outcomes of Steroid-Based versus Steroid-Avoidant Immunosuppression in Pediatric Kidney Transplant Recipients
N. Hayde¹, E. Blanchette², J. Zhang³, M. Chandran², M. Bock², S. Galbiati³, T. Blydt-Hansen⁴
¹Montefiore Medical Center, Bronx, NY, ²Children's Hospital Colorado, Aurora, CO, ³Emmes Corporation, Rockville, MD, ⁴University of British Columbia, Vancouver, BC, Canada
*Purpose: With increasing use of potent immunosuppressant (IS) medications, steroid-avoidant (SA) regimens are now commonly used for pediatric kidney transplant recipients (pKTs) to avoid potential…
2022 American Transplant Congress
Digital Spatial Profiling of Kidney Allograft Biopsies with Chronic Allograft Dysfunction in African American Transplant Recipients
C. R. Dorr¹, S. A. Elmer¹, B. Wu², B. Guo², J. Czyzyk², G. Crary³, G. Onyeaghala¹, W. Oetting², P. Jacobson², R. B. Mannon⁴, G. Agarwal⁵, J. Maltzman⁶, A. Matas², A. Israni³
¹Hennepin Healthcare Research Institute, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³Hennepin County Medical Center, Minneapolis, MN, ⁴Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Stanford University, Palo Alto, CA
*Purpose: Understanding tissue heterogeneity is important to identify the molecular and cellular mechanisms of kidney allograft loss in African American (AA) transplant recipients. Our aim…