ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Sirolimus Use Is Associated With An Improved Immune Response To Covid-19 Vaccination In Kidney Transplant Recipients

    G. B. Perkins1, M. Tunbridge2, T. Salehi2, C. Chai1, C. M. Hope1, P. Garcia-Valtanen1, J. J. Singer3, P. R. Hurtado2, S. C. Barry1, B. Grubor-Bauk1, P. Hissaria2, S. J. Chadban3, P. Coates1

    1University of Adelaide, Adelaide, Australia, 2Royal Adelaide Hospital, Adelaide, Australia, 3Royal Prince Alfred Hospital, Sydney, Australia

    *Purpose: Kidney transplant recipients (KTRs) are highly vulnerable to severe COVID-19, however are poorly protected by vaccination. Additional vaccine doses have achieved limited improvements in…
  • 2022 American Transplant Congress

    Renal Graft Outcomes in Simultaneous Heart-Kidney Transplantation

    K. Okumura, S. Ohira, M. Kai, K. Wolf, A. L. Gass, D. Spielvogel, N. Singh, D. Glicklich, D. John, T. Diflo, S. Lansman, S. Nishida, A. Dhand

    Westchester Medical Center / New York Medical College, Valhalla, NY

    *Purpose: Simultaneous heart and kidney transplantation (SHKT) has increased steadily in United States Previously it was shown that SHKT is associated with benefits in overall…
  • 2022 American Transplant Congress

    Higher Baseline Serum Creatinine Levels AreAssociated with an Increased Incidence of Renal Replacement Therapy in Patients with Hepatorenal Syndrome Type 1 on the Liver Transplant Waitlist

    S. N. Sclair1, A. Befeler2, K. Jamil3

    1Hepatology, University Hospitals Cleveland Medical Center & Case Western Reserve University, Cleveland, OH, 2Gastroenterology, Hepatology, Transplant Hepatology, Saint Louis University School of Medicine, St Louis, MO, 3Hepatology, Mallinckrodt Pharmaceuticals, Clinton, NJ

    *Purpose: Pretransplant and posttransplant renal replacement therapy (RRT) is associated with increased morbidity and mortality in liver transplant recipients, including those with Hepatorenal syndrome type…
  • 2022 American Transplant Congress

    Abnormal B Cell Profile Associated with Inadequate Antibody Response to MRNA SARS-COV-2 Vaccine Can Be Overcome with a Third Vaccine Dose in Adolescent Kidney Transplant Recipients

    C. Crane, E. Phebus, L. Loop, C. Anterasian, B. Geng, E. Ingulli

    Pediatrics, UCSD Rady Children's, San Diego, CA

    *Purpose: mRNA SARS-CoV-2 vaccines are highly efficacious in the general population but have shown a diminished response in immunosuppressed adolescent kidney allograft recipients. We investigated…
  • 2022 American Transplant Congress

    EBV+ PTLD Tumor MicroRNAs Detected in Circulating Extracellular Vesicles Are Decreased in Pediatric Transplant Recipients with EBV+ PTLD

    A. Sen1, J. Enriquez1, M. Rao1, M. Glass1, Y. Balachandran1, S. Syed1, C. Twist1, K. Weinberg1, S. D. Boyd1, D. Bernstein1, A. Trickey1, D. Gratzinger1, B. Tan1, M. G. Lapasaran1, M. A. Robien2, M. Brown3, B. Armstrong4, M. Sever4, D. Desai5, G. Mazariegos6, C. Chin7, T. Fishbein8, R. S. Venick9, A. Tekin10, H. Zimmermann11, R. U. Trappe12, C. O. Esquivel1, O. M. Martinez1, S. M. Krams1

    1Stanford U, Palo Alto, CA, 2NIH, Bethesda, MD, 3NIAID, Bethesda, MD, 4Rho, Durham, NC, 5UT Southwestern, Dallas, TX, 6Pittsburgh U, Pittsburgh, PA, 7CCHMC, Cincinnati, OH, 8Georgetown U, Washington, DC, 9UCLA, LA, CA, 10Miami U, Miami, FL, 11DIAKO Ev. Diakonie-Krankenhaus, Bremen, Germany, 12Charité - Universitätsmedizin, Berlin, Germany

    *Purpose: Post-transplant lymphoproliferative disorder (PTLD) is a serious complication of solid organ transplantation. Predisposing factors for PTLD include primary Epstein-Barr virus (EBV) infection in children,…
  • 2022 American Transplant Congress

    Transjugular Intrahepatic Portosystemic Shunt Placement is Associated with Increased All-Cause and Cardiac Mortality in Those Undergoing Liver Transplant for Nonalcoholic Steatohepatitis

    D. U. Lee1, J. Han2, J. Kwon2, K. Chang2, G. Fan2, K. Lee1, N. Urrunaga3, C. Bhati1, D. Maluf3, K. Shetty3

    1Department of Gastroenterology and Hepatology, University of Maryland, Baltimore, MD, 2Tufts Medical Center, Boston, MA, 3University of Maryland, Baltimore, MD

    *Purpose: Since the effect of transjugular intrahepatic portosystemic shunt (TIPS) on post LT outcomes is not well understood, we undertook this analysis of a large…
  • 2022 American Transplant Congress

    Comparison of Immediate-Release Tacrolimus to Envarsus XR on the Development of Donor Specific Antibodies in Kidney Transplant Recipients

    R. A. Arora, C. Kane, K. Lang, M. Kapugi, C. D'Agostino, K. Cunningham, S. H. Park

    Northwestern Memorial Hospital, Chicago, IL

    *Purpose: Major causes of de novo development of donor specific antibodies (DSA) after kidney transplant include medication noncompliance and immunosuppression minimization or elimination that may…
  • 2022 American Transplant Congress

    Variation in Adult Living Donor Liver Transplantation in the United States: Identifying Opportunities for Increased Utilization

    K. Lentine1, D. Axelrod2, M. Schnitzler1, R. Li1, M. Dew3, T. Bitterman4, K. Olthoff4, J. Locke5, S. Emre6, H. Hunt7, T. Tanaka2, A. Liapakis6

    1Saint Louis University, St. Louis, MO, 2U Iowa, Iowa City, IA, 3U Pittsburgh, Pittsburgh, PA, 4U Penn, Philadelphia, PA, 5UAB, Birmingham, AL, 6Yale, New Haven, CT, 7UNOS, Richmond, VA

    *Purpose: To assess barriers to living donor liver transplant (LDLT) access in light of convincing evidence of survival benefits for patients with end-stage liver disease.*Methods:…
  • 2022 American Transplant Congress

    Early Outcomes for Liver Transplant with Thoracoabdominal Normothermic Regional Perfusion for Donation After Circulatory Death: A Multi-Center Experience

    A. L. Brubaker1, A. Lee1, B. Jackson1, J. Berumen1, J. R. Parekh1, K. L. Mekeel1, A. R. Gupta2, J. M. Gardner2, T. Chaly3, A. K. Mathur4, C. Jadlowiec4, K. Reddy4, R. Nunez4, J. Bellingham5, E. Thomas6, J. R. Wellen7, M. Kearns1, V. Pretorius1, G. T. Schnickel1

    1UC San Diego, San Diego, CA, 2UC San Francisco, San Francisco, CA, 3Arizona Transplant Associates, Phoenix, AZ, 4Mayo Clinic Arizona, Phoenix, AZ, 5California Pacific Medical Center, Orinda, CA, 6University of Texas, San Antonio, TX, 7Washington University, Saint Louis, MO

    *Purpose: We evaluated early outcomes of liver transplant after thoracoabdominal normothermic regional perfusion (TA-NRP) for controlled donation after circulatory death (cDCD) donors.*Methods: We identified liver…
  • 2022 American Transplant Congress

    Digital Spatial Profiling of Kidney Allograft Biopsies with Chronic Allograft Dysfunction in African American Transplant Recipients

    C. R. Dorr1, S. A. Elmer1, B. Wu2, B. Guo2, J. Czyzyk2, G. Crary3, G. Onyeaghala1, W. Oetting2, P. Jacobson2, R. B. Mannon4, G. Agarwal5, J. Maltzman6, A. Matas2, A. Israni3

    1Hennepin Healthcare Research Institute, Minneapolis, MN, 2University of Minnesota, Minneapolis, MN, 3Hennepin County Medical Center, Minneapolis, MN, 4Medicine, University of Nebraska Medical Center, Omaha, NE, 5University of Alabama at Birmingham, Birmingham, AL, 6Stanford University, Palo Alto, CA

    *Purpose: Understanding tissue heterogeneity is important to identify the molecular and cellular mechanisms of kidney allograft loss in African American (AA) transplant recipients. Our aim…
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