Abstracts Archive - Page 602 of 1683 - ATC Abstracts

2019 American Transplant Congress
Increased Frequency of Myeloid-Derived Suppressor Cells Contributing to Prolong Skin Allograft Survival in Aged Mice
W. Lee, Y. Wang, T. Wu, C. Cheng, C. Lee, T. Wu, H. Chou, K. Chan
General Surgery, Chang-gung Hospital, Taoyuan, Taiwan
*Purpose: Currently, aged people are increasing and more and more aged people have organ transplantation. The immunity in aged people is weaker than young people.…
2019 American Transplant Congress
The Effects of Chronic Kidney Disease on Antiviral T Cell Response
R. L. Crepeau¹, H. Li², L. P. Daley-Bauer³, M. L. Ford¹, P. D. Winterberg²
¹Emory Transplant Center, Atlanta, GA, ²Pediatrics, Emory University School of Medicine, Atlanta, GA, ³Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA
*Purpose: Accumulation of memory T cells bearing markers of sustained antigen stimulation have been described in patients with chronic kidney disease (CKD). Cytomegalovirus (CMV) establishes…
2019 American Transplant Congress
T Cell-Intrinsic Dysfunction in Donor-Specific Transplantation Tolerance
C. M. McIntosh¹, M. L. Miller², Y. Wang¹, A. Chong³, M. Alegre¹
¹Department of Medicine, University of Chicago, Chicago, IL, ²Department of Immunology, University of Pittsburgh, Pittsburgh, PA, ³Department of Surgery, University of Chicago, Chicago, IL
*Purpose: Donor-specific tolerance offers many advantages over current lifelong non-specific immunosuppression strategies, but the mechanisms by which it may be durably maintained remain to be…
2019 American Transplant Congress
Endogenous Erythropoietin is Required for Spontaneous Acceptance of Murine Renal Allografts
J. Horwitz, P. Cravedi, P. Heeger
Icahn School of Medicine at Mount Sinai, NY, NY
*Purpose: B6 recipients spontaneously accept MHC-disparate renal allografts from allogeneic DBA/2 x B6 (H-2d x H-2b) F1 donors via mechanisms that are in part regulatory…
2019 American Transplant Congress
Tolerance to ABO A-Antigen Following Treatment of Infant Mice with A-Expressing MHC-Identical Erythrocytes
B. Motyka¹, J. Fersovich¹, M. Sulzer¹, I. Adam¹, J. Pearcey¹, K. Tao¹, C. W. Cairo², P. J. Cowan³, L. J. West¹
¹Dept Pediatrics, Alberta Transplant Institute, Canadian Donation and Transplant Research Program, University of Alberta, Edmonton, AB, Canada, ²Department of Chemistry, University of Alberta, Edmonton, AB, Canada, ³Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia
*Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe in young children and increases donor access. Post-ABOi HTx, B cell tolerance develops to donor ABO blood…
2019 American Transplant Congress
Bcl-2/Bcl-xL Inhibition by Navitoclax vs. Bcl-2 Alone Inhibition by Venetoclax for Induction of Mixed Chimerism in Non-Human Primates
H. Sasaki¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, I. Rosales², B. Cosimi¹, P. Cippa³, T. Fehr³, T. Kawai¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA, ³Medicine, University of Zurich, Zurich, Switzerland
*Purpose: We recently demonstrated that a specific Bcl-2 inhibitor, Venetoclax, can promote mixed chimerism and renal allograft tolerance in non-human primates (NHPs) with reduced myelosuppressive…
2019 American Transplant Congress
ECDI-Treated Donor Leukocytes in Primate Cardiac Allograft Recipients
Z. Alikhassy Habibabady¹, T. Zhang², W. Sun², X. Cheng², L. Burdorf¹, I. Tatarov², S. Sendil², I. Behroozfard², B. Cerel¹, D. Parsell², R. N. Pierson III¹, X. Luo³, A. M. Azimzadeh¹
¹Surgery, Massachusetts General Hospital and Harvard School of Medicine, Boston, MA, ²Surgery, University of Maryland School of Medicine, Baltimore, MD, ³Duke Transplant Center, Duke University, Durham, NC
*Purpose: Ethyl carbodiimide (ECDI)-fixed donor leukocytes exhibit tolerogenic immunomodulation in murine models of autoimmunity and transplantation, and nonhuman primate islet transplantation. Here in pilot studies…
2019 American Transplant Congress
Immunologically Tolerant Liver Transplant Recipients Are Characterized by Donor-Specific Hypo Responsiveness of Circulating T-cells
A. A. Duizendstra¹, R. J. Knegt de¹, M. G. Betjes², M. P. Peppelenbosch¹, N. H. Litjens², J. Kwekkeboom¹
¹Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, Netherlands, ²Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands
*Purpose: Lifelong treatment with immunosuppressive drugs (IS) to prevent graft rejection in transplant recipients is accompanied by side effects. Some recipients are considered to be…
2019 American Transplant Congress
Deficiency of the Transcription Factor Satb1 in T Cells Promotes Solid Organ Allograft Survival
P. K. Gupta¹, M. L. Miller², L. Chen¹, Y. Wang¹, J. Conejo-Garcia³, A. Chong¹, M. Alegre¹
¹University of Chicago, Chicago, IL, ²University of Pittsburgh, Pittsburgh, PA, ³Moffitt Cancer Center & Research Institute, Tampa, FL
*Purpose: Conventional CD4+ T cells are key effectors of allograft rejection and novel therapies limiting their response may hold promise in the context of organ…
2019 American Transplant Congress
Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice
Y. Huang, H. Xu, Y. Wen, S. Ildstad
University of Louisville, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…