Abstracts Archive - Page 60 of 1683 - ATC Abstracts

2022 American Transplant Congress
Which is More Important for Predicting De Novo DSA Production, B Cell Epitope (EPLET) or T Cell Epitope (PIRCHE) Analysis ?
T. Kobayashi¹, T. Tomosugi², S. Sakamoto², S. Ashimine¹, K. Iwasaki¹, M. Niemann³, E. Spierings⁴, Y. Miwa¹, M. Okumura¹, K. Ishiyama¹, A. Takeda², N. Goto², S. Narumi², Y. Watarai²
¹Aichi Medical University School of Medicine, Nagakute, Japan, ²Nagoya Daini Red Cross Hospital, Nagoya, Japan, ³PIRCHE AG, Berlin, Germany, ⁴UMC Utrecht, Utrecht, Netherlands
*Purpose: De novo donor-specific antibodies (dnDSA) can cause chronic ABMR, resulting in poor prognosis. Recently, mismatch at B cell epitope level, i.e. EPLET mismatch, has…
2022 American Transplant Congress
Abnormal B Cell Profile Associated with Inadequate Antibody Response to MRNA SARS-COV-2 Vaccine Can Be Overcome with a Third Vaccine Dose in Adolescent Kidney Transplant Recipients
C. Crane, E. Phebus, L. Loop, C. Anterasian, B. Geng, E. Ingulli
Pediatrics, UCSD Rady Children's, San Diego, CA
*Purpose: mRNA SARS-CoV-2 vaccines are highly efficacious in the general population but have shown a diminished response in immunosuppressed adolescent kidney allograft recipients. We investigated…
2022 American Transplant Congress
Differentially Methylated Genes Predict Post-Transplant Relapse of Unresectable Hepatoblastoma
M. Ningappa¹, M. Muarya², C. Ashokkumar¹, H. Hakonarson³, S. Subramaniam⁴, R. Sindhi¹
¹Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²Department of Bioengineering & San Diego Supercomputer Center, University of California, San Diego, CA, ³Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Department of Computer Science and Engineering, and Nanoengineering, University of California, San Diego, La Jolla, CA
*Purpose: Hepatoblastoma (HB), a developmental liver tumor of childhood requires liver transplantation (LT) if it remains unresectable despite chemotherapy. Post-transplant relapse in up to 20%…
2022 American Transplant Congress
Long-Term Outcomes of Crossmatch Positive Simultaneous Liver Kidney Transplants in the United States
S. Riad¹, E. Aby¹, S. Jackson², P. Nguyen³, N. Lim¹, J. Lake¹
¹Medicine, University of Minnesota, Minneapolis, MN, ²Mhealth-Fairview, Minneapolis, MN, ³Surgery, University of Minnesota, Minneapolis, MN
*Purpose: The long-term results of crossmatch positive (XM+) simultaneous liver-kidney (SLK) transplants are conflicting. We examined the association between crossmatch (XM) status and SLK outcomes…
2022 American Transplant Congress
Comparing Disparities in Access to First and Re-Kidney Transplantation Among Hispanic and Black Adults in the United States
S. Sandal¹, J. Ahn², V. Thompson³, T. Purnell⁴, M. Cantarovich⁵, D. Segev³, M. McAdams DeMarco³
¹McGill University, Montreal, QC, Canada, ²SOM, Johns Hopkins University, Baltimore, MD, ³Johns Hopkins University, Baltimore, MD, ⁴Johns Hopkins School of Medicine, Baltimore, MD, ⁵McGill University Health Ctr, Montreal, QC, Canada
*Purpose: There are significant racial/ethnic disparities in access to solid organ transplantation; lack of education and familiarity with the transplant process are postulated contributors. Among…
2022 American Transplant Congress
Long-Term Outcomes for Living Kidney Donors with Early Guideline-Concordant Follow-Up Care
A. Dhalla¹, A. Lloyd², K. L. Lentine³, A. X. Garg⁴, R. R. Quinn¹, P. Ravani¹, S. W. Klarenbach², B. R. Hemmelgarn², U. Ibelo¹, N. N. Lam¹
¹Department of Medicine, Division of Nephrology, University of Calgary, Calgary, AB, Canada, ²Department of Medicine, Division of Nephrology, University of Alberta, Edmonton, AB, Canada, ³Center for Abdominal Transplantation, Saint Louis University, St. Louis, MO, ⁴Department of Medicine, Division of Nephrology, Western University, London, ON, Canada
*Purpose: Current guidelines recommend that living kidney donors receive annual lifelong follow-up to monitor kidney health. It is unclear whether early guideline-concordant care is associated…
2022 American Transplant Congress
Degree of Pre-Liver Transplant Immune Dysfunction Correlates with Post-Transplant Cancer Recurrence
G. S. Prakash¹, G. G. Panayotova¹, S. Simonishvili¹, Y. Qin¹, L. Jin¹, T. Ayorinde¹, L. J. Minze², F. Paterno¹, L. Brown¹, A. Amin¹, D. Liu¹, R. Ghobrial², J. V. Guarrera¹, K. E. Lunsford¹
¹Rutgers New Jersey Medical School, Newark, NJ, ²Houston Methodist Hospital, Houston, TX
*Purpose: Despite stringent selection criteria for liver transplant (LT) in patients with liver-limited malignancy, post-transplant cancer recurrence remains problematic. We have previously identified a pre-LT…
2022 American Transplant Congress
Validation of a Hypertension Risk Calculator for Living Kidney Donors
E. S. Helgeson¹, S. Vempati¹, E. F. Palzer¹, G. Mjøen², A. J. Haugen³, A. Matas⁴
¹Division of Biostatistics, University of Minnesota, Minneapolis, MN, ²Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway, ³Department of Internal Medicine, Bærum Hospital, Sandvika, Norway, ⁴Department of Surgery, University of Minnesota, Minneapolis, MN
*Purpose: It would be ideal if candidates considering kidney donation understood their long-term risks. Using single-center data (n=4055; median [IQR] f/u: 18 [9-28] yrs), we…
2022 American Transplant Congress
Area Deprivation Index is Associated with Worse Patient Survival Following Adult Liver Transplantation
J. Hendele¹, J. Perkins², J. Nichols³, A. Dick¹
¹Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, WA, ²Clinical and Bio-Analytics Transplant Laboratory (CBATL), University of Washington, Division of Transplant Surgery, Department of Surgery, Seattle, WA, ³School of Medicine, University of Washington, Seattle, WA
*Purpose: Area Deprivation Index (ADI) has been utilized as a granular measure of local socioeconomic status for nearly two decades. This study is the first…
2022 American Transplant Congress
Changes in Health Equity Under Liver Acuity Circles Allocation
S. Noreen, J. Foutz, A. Henderson, D. Stewart
United Network for Organ Sharing, Richmond, VA
*Purpose: Acuity circles (AC) allocation was implemented on 2/4/2020 with a goal of removing DSA and region from liver allocation and sharing livers more broadly.…