Abstracts Archive - Page 594 of 1683 - ATC Abstracts

2019 American Transplant Congress
Biomarkers in Multivisceral and Intestinal Transplantation
D. A. Cheung¹, J. Garcia¹, T. Beduschi², A. H. Langshaw¹, K. L. Arheart³, I. A. Gonzalez⁴
¹Pediatric Gastroenterology, University of Miami, Miami, FL, ²Surgery, Division of Liver/GI Transplant, University of Miami, Miami, FL, ³Public Health Sciences, Division of Biostatistics, University of Miami, Miami, FL, ⁴Pediatric Infectious Diseases and Immunology, University of Miami, Miami, FL
*Purpose: Multivisceral transplant (MVT) and isolated intestinal transplant (ITx) are complex surgical procedures that result in a pro-inflammatory state, making interpretation of biomarkers in the…
2019 American Transplant Congress
Viral Enteritis in Intestinal Transplant Recipients
A. Servais, M. Vacha, D. F. Florescu, M. Keck
Nebraska Medicine, Omaha, NE
*Purpose: To evaluate viral enteritis episodes in intestinal transplant recipients (ITR)*Methods: This retrospective review included ITR transplanted between January 2008 and December 2016. Data for…
2019 American Transplant Congress
Effects of Major Liver Allocation Policy Changes on Waitlist Outcomes in Multivisceral Transplantation
S. Nagai¹, M. Rizzari¹, Y. Muszkat², K. Collins¹, A. Yoshida¹, S. Jafri², M. Abouljoud¹
¹Transplant and Hepatobiliary Surgeryery, Henry Ford Hospital, Detroit, MI, ²Gastroenterology, Henry Ford Hospital, Detroit, MI
*Purpose: Liver-intestine allocation is determined in the liver waitlist. This study aimed to evaluate effects of recent updates in liver allocation policy on waitlist outcomes…
2019 American Transplant Congress
Identification of Adult Liver Transplant Recipients Eligible to Participate in an Immunosuppression Withdrawal Trial Employing Non-Invasive Assessments of Allograft Status
J. Vionnet¹, R. Miquel¹, A. Douiri¹, M. Elstad¹, E. Kodela¹, A. Quaglia², J. Wall¹, P. Ruiz Martin¹, E. B. Riani³, J. Leithead⁴, A. Marshall², M. Navasa⁵, P. Ruiz⁵, J. Ferguson⁶, K. Simpson⁷, A. Pascher⁸, E. Jaeckel⁹, R. Bishop¹⁰, F. Nevens¹¹, S. Masson¹², A. Sanchez-Fueyo¹
¹King's College London, London, United Kingdom, ²Royal Free, London, United Kingdom, ³St-Luc, Brussels, Belgium, ⁴Addenbrookes, Cambridge, United Kingdom, ⁵Hospital Clinic, Barcelona, Spain, ⁶Queen Elizabeth, Birmingham, United Kingdom, ⁷Royal Infirmary, Edinburgh, United Kingdom, ⁸Charité, Berlin, Germany, ⁹Hannover Medical School, Hannover, Germany, ¹⁰Leeds NHS Trust, Leeds, United Kingdom, ¹¹UZ Leuven, Leuven, Belgium, ¹²Hepatology, Newcastle, United Kingdom
*Purpose: Liver Immunosuppression Free Trial (LIFT) is a multicentre international prospective randomised controlled trial of biomarker-guided immunosuppression withdrawal in adult liver transplant recipients who meet…
2019 American Transplant Congress
Inflammation and Fibrosis Are Observed in 34% of Clinically Stable Adult Liver Transplant Recipients
L. Sun¹, J. Levitsky², S. Feng³, A. Humar⁴, A. J. Demetris⁴, J. Emond⁵, A. Shaked⁶, G. Klintmalm⁷, K. Mason⁸, M. DesMarais¹, A. Priore⁹, N. Bridges⁹, B. E. Burrell¹⁰, S. Chandran³, J. Markmann¹¹
¹ITN, San Francisco, CA, ²Northwestern, Chicago, IL, ³UCSF, San Francisco, CA, ⁴UPMC, Pittsburg, PA, ⁵Columbia, New York, NY, ⁶UPenn, Philadelphia, PA, ⁷Baylor, Dallas, TX, ⁸Rho, Chapel Hill, NC, ⁹NIAID, Bethesda, MD, ¹⁰ITN, Bethesda, MD, ¹¹MGH, Boston, MA
*Purpose: OPTIMAL is a 7-center immunosuppression withdrawal (ISW) study in non-autoimmune, non-HCV adult liver transplant recipients ≥3 yrs post-transplant (tx) (NCT02533180). Subjects underwent a screening…
2019 American Transplant Congress
A Novel Protocol to Produce Massive Amounts of Autologous Thymus-Derived Treg Cells (ThyTreg) to Be Employed as Cellular Therapy in Heart Transplanted Children: A New Paradigm for the Prevention of Graft Rejection
E. Bernaldo de Quirós¹, R. López¹, V. Pérez¹, M. Clemente², J. Gil-Jaurena³, M. Camino⁴, N. Gil⁴, E. Panadero⁴, C. Medrano⁴, M. Pion¹, R. Correa-Rocha¹
¹Laboratory of Immune-regulation, Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, Spain, ²Cell Culture Unit, Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, Spain, ³Pediatric Cardiac Surgery Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ⁴Pediatric Cardiology Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain
*Purpose: Immune allograft rejection remains the main obstacle to successful transplants. Although transfer of regulatory T cells (Treg) has acquired growing interest in achieving indefinite…
2019 American Transplant Congress
Mismatched Antibody Epitopes and the Development of HLA-DQ De Novo DSA during Immunosuppression Withdrawal in Liver Transplant Recipients
V. Jucaud¹, A. Shaked², M. DesMarais³, P. Sayre⁴, S. Feng⁴, J. Levitsky⁵, M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²University of Pennsylvania, Philadelphia, PA, ³Immune Tolerance Network, San Francisco, CA, ⁴University of California San Francisco, San Francisco, CA, ⁵Northern Western University, Chicago, IL
*Purpose: We recently described, in liver transplant (LT) recipients from the ITN030ST study, the development of de novo donor-specific HLA antibodies (dnDSA) and their impact…
2019 American Transplant Congress
Paradoxical Liver Simulated Allocation Model (LSAM) Projections for Changes to Waitlist Mortality under Acuity Circle Distribution Model
R. Lynch¹, K. Ross¹, S. Karp²
¹Emory, Atlanta, GA, ²Vanderbilt, Nashville, TN
*Purpose: In December 2018, the United Network for Organ Sharing (UNOS) board voted to change liver transplant distribution from Donor Service Areas (DSAs) to a…
2019 American Transplant Congress
Recipient Predictors of Post-Donation End Stage Renal Disease in Living Kidney Donors
J. Wainright¹, A. Robinson¹, A. Wilk¹, D. Klassen², W. Cherikh¹, L. Cartwright¹, D. Stewart¹
¹Research, UNOS, Richmond, VA, ²UNOS, Richmond, VA
*Purpose: We studied associations between kidney transplant recipient diagnosis and other factors and development of ESRD among related living kidney donors (LKDs).*Methods: Using OPTN listing…
2019 American Transplant Congress
Transplantation of Hepatitis C Virus Positive Donor Kidneys into Hepatitis C Negative Older Recipients
J. A. Graham¹, M. Ajaimy², J. Torabi¹, T. Powell³, J. Weiss⁴, T. Weinstein⁵, S. Greenstein¹, O. Andacoglu¹, A. Campbell⁶, J. Carrero¹, J. Lapponese¹, M. Kinkhabwala¹, E. Akalin², J. P. Rocca¹
¹Surgery, Montefiore Medical Center, Bronx, NY, ²Medicine, Montefiore Medical Center, Bronx, NY, ³Epidemiology and Psychiatry, Montefiore Medical Center, Bronx, NY, ⁴Medical Affairs, Montefiore Medical Center, Bronx, NY, ⁵Risk & Loss Prevention, Montefiore Medical Center, Bronx, NY, ⁶Pharmacy, Montefiore Medical Center, Bronx, NY
*Purpose: Patients awaiting transplantation are often at risk of developing life-threatening disease and complications. Older patients have a disproportionately higher risk of dropping out of…