Abstracts Archive - Page 584 of 1683 - ATC Abstracts

2019 American Transplant Congress
Notch1 Signaling Protects Liver Grafts from Ischemia Reperfusion Injury: From Mouse to Human
K. Kadono, S. Kageyama, H. Hirao, K. Nakamura, T. Ito, K. J. Dery, D. Oncel, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski
Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: The clinical relevance and tissue-specific role of Notch1 activation, a highly conserved transmembrane receptor involved in cell fate decision, proliferation and regeneration, in orthotopic…
2019 American Transplant Congress
Organ-Specific Injury and Recovery Mechanisms in Post-Transplant Ischemia Reperfusion Injury
S. Bontha¹, A. Bajwa¹, L. Gallon², J. Eason³, D. Maluf¹, V. Mas⁴
¹UTHSC, Memphis, TN, ²Northwestern University, Chicago, IL, ³Director of Transplant Institute UTHSC, Memphis, TN, ⁴Director of Transplant Research Institute, Memphis, TN
*Purpose: Ischemia reperfusion (I/R) injury is a major contributor to short-term graft function. Dissecting organ specific and common molecular pathways associated with I/R injury among…
2019 American Transplant Congress
CXCL12-CXCR4-Mediated Chemotaxis is a Potential Mechanism for Monocyte Recruitment in Ischemia-Reperfusion Injury in Orthotopic Liver Transplant Patients
A. Q. Terry¹, R. A. Sosa¹, B. V. Naini¹, V. Groysberg¹, F. M. Kaldas², R. W. Busuttil², D. Gjertson¹, J. Kupiec-Weglinski², E. F. Reed¹
¹Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, ²Surgery, University of California, Los Angeles, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) elicits cellular damage which lowers allograft survival in orthotopic liver transplant (OLT) patients. Damage-associated molecular patterns, such as high-mobility group box…
2019 American Transplant Congress
Urine Recirculation Maintains Hemodynamics and Enhances Function in Normothermic Kidney Perfusion
A. Weissenbacher¹, C. D. Ceresa², D. Voyce³, J. Hunter², R. Ploeg², C. C. Coussios⁴, P. Friend²
¹Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria, ²Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ³OrganOx Limited, Oxford, United Kingdom, ⁴Oxford Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom
*Purpose: The purpose was to compare urine recirculation (URC) and urine replacement with Ringer’s lactate in a porcine normothermic kidney perfusion (NKP) model using a…
2019 American Transplant Congress
The Effect of the Beneficial Activity of α-Lipoic Acid Treatment Depend on the Quality of the Graft Kidneys
F. Osella¹, N. Ambrosi², G. Werber¹, F. Caro², S. Beltramino¹, I. Cabrera¹, G. Hilchenbach¹, L. Diaz Alvarez¹, C. Incardona³, E. Chuluyan², D. Casadei¹
¹Instituto de Trasplante y Alta Complejidad, Buenos Aires, Argentina, ²CEFYBO, UBA, Buenos Aires, Argentina, ³GADOR S.A., Buenos Aires, Argentina
*Purpose: In a previous preliminary study, with a small number of patients, we observed that the treatment of the donor and the recipient with the…
2019 American Transplant Congress
Partial Freezing: Subzero Whole Liver Preservation In The Presence Of Ice
S. E. Cronin¹, C. A. Pendexter¹, R. J. deVries¹, S. Kimura², S. Ozer¹, P. D. Banik¹, S. Nagpal¹, H. Yeh², S. N. Tessier¹, K. Uygun¹, M. Toner¹
¹Center for Engineering in Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: We aim to develop a protocol to bank organs for several days, enabling global organ matching and potentially the utilization of organs unusable with…
2019 American Transplant Congress
Assessing Discarded Human Liver Quality with Normothermic Ex-Vivo Liver Perfusion
F. Zhou, M. Xu, S. Garcia-Aroz, G. A. Upadhya, Y. Lin, W. C. Chapman
Surgery, Washington University in St. Louis, St. Louis, MO
*Purpose: Normothermic Ex-vivo Liver Perfusion (NELP) of livers shows promising results in overcoming injuries that occur in deceased donor liver transplantation. The effect of NELP…
2019 American Transplant Congress
Apparatus and Method to Facilitate In-Situ Cold Perfusion of Abdominal Organs in DCD Donors
M. Jendrisak
Gift of Hope Organ & Tissue Donor Network, Itasca, IL
*Purpose: Rapid, effective in-situ cold perfusion of the abdominal organs in the setting of donation after circulatory death (DCD) is a critical surgical task to…
2019 American Transplant Congress
C1 Esterase Inhibitor (C1INH) Treatment at Kidney Transplant Improves Long-Term Outcomes in Patients at Risk for Ischemia/Reperfusion Injury & Delayed Graft Function
S. Jordan¹, E. Huang², N. Ammerman¹, J. Choi¹, O. Aubert³, S. Kumar¹, A. Loupy⁴, A. Peng¹, I. Kim¹, R. Najjar¹, D. Puliyanda¹, T. Brennan¹, S. Sethi¹, A. Vo¹
¹Cedars Sinai Medical Ctr, West Hollywood, CA, ²Comprehensive Transplant Center, Cedars Sinai Medical Ctr, West Hollywood, CA, ³Biostatistics Department, Paris Translational Research Center for Organ Transplantation, Paris, France, ⁴Biostatistics, Paris Translational Research Center for Organ Transplantation, Paris, France
*Purpose: Delayed graft function(DGF) is defined as need for dialysis early post-transplant. DGF is related to ischemia reperfusion injury (IRI) that diminishes allograft function and…
2019 American Transplant Congress
Early Allograft Dysfunction in the Setting of Histologic Ischemia Reperfusion Injury Following Liver Transplantation: Analysis of Predictors and Outcomes
T. Ito, J. Aziz, V. G. Agopian, S. Younan, J. DiNorcia, H. Yersiz, D. G. Farmer, R. W. Busuttil, F. M. Kaldas
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Hepatic ischemia-reperfusion injury (IRI) in Liver Transplantation (LT) is believed to contribute to Early Allograft Dysfunction (EAD). However, the relationship between IRI and EAD…