2019 American Transplant Congress
mTOR Inhibitors Associated with Higher Cardiovascular Adverse Events – A Large Population Database Analysis
*Purpose: Our study aimed to compare the adverse events (AEs) of tacrolimus to mammalian target of rapamycin (mTOR) inhibitors in solid organ transplant patients.*Methods: Our…2019 American Transplant Congress
Impact of Everolimus Therapy on HIV Persistence and Gene Expression in Transplant Patients
1UC San Francisco, San Francisco, CA, 2Case Western Reserve University, Cleveland, OH
*Purpose: mTOR is a key regulatory kinase that controls cell-cycle progression. mTOR inhibitors have been shown to reduce expression of CCR5 and promote viral transcriptional…2019 American Transplant Congress
Evaluation of Mycophenolate Mofetil Exposure in Renal Transplant Recipients
*Purpose: Mycophenolate mofetil (MMF) is the most commonly prescribed immunosuppressant following transplantation in the United States. However, the occurrence of MMF therapy-related adverse events including…2019 American Transplant Congress
Safety and Efficacy of Anti Xa Inhibitors Post-Transplant with Concomitant Calcineurin Inhibitors
*Purpose: Despite demonstrated benefits of Anti-Xa Inhibitors (ATIs) in the general population, ATIs have not gained uniform acceptance in SOT due to lack of supportive…2019 American Transplant Congress
Apixaban Therapy Is Safe And Effective In Most Organ Transplant Populations
University of Virginia Health System, Charlottesville, VA
*Purpose: The bleed rates from the apixaban pivotal trial were 12.1% for non-major and 3.8% major bleeds. However outcomes in transplant recipients are less defined,…2019 American Transplant Congress
The lncRNA-mRNA Co-Expression Analysis in Acetaminophen-Induced Liver Injury
*Purpose: Acetaminophen (APAP) could cause liver injury, or even acute liver failure, accounting for approximately one-half of all cases in developed countries. Once acute liver…2019 American Transplant Congress
Clinical Utility of a Pharmacogenomic Testing Tool among Kidney Transplant Recipients
Kidney/Pancreas Transplant Program, Intermountain Medical Center, Murray, UT
*Purpose: Therapeutic drug monitoring (TDM) for tacrolimus (Tac) is the cornerstone of clinical workflow in the transplant clinic. We report on the clinical implementation of,…2019 American Transplant Congress
CURATE.AI: Personalized Liver Transplant Tacrolimus Dosing
*Purpose: Transplant immunosuppressive regimens include multiple drugs with varying pharmacokinetics, metabolic pathways, and drug-drug interactions. This study aimed to use CURATE.AI, an artificial intelligence platform,…2019 American Transplant Congress
Anti-Xa Level Monitoring for Treatment Dose Enoxaparin in Liver/Intestine Transplant Recipients
Jackson Memorial Hospital, Miami, FL
*Purpose: Evaluate the use of anti-Xa levels in therapeutic enoxaparin dosing in liver/intestine transplant recipients.*Methods: A single-center retrospective chart review was conducted on liver/intestine transplant…2019 American Transplant Congress
Direct Oral Anticoagulants: An Evaluation of the Safety and Efficacy in Solid Organ Transplant Recipients
Tampa General Hospital, Tampa, FL
*Purpose: The use of direct oral anticoagulants (DOACs) has not been fully adopted by the solid organ transplant (SOT) community due to factors including, fluctuating…
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