Abstracts Archive - Page 574 of 1683 - ATC Abstracts

2019 American Transplant Congress
Treg Lymphotoxin and Lymphatic Endothelial Cell Lymphotoxin Receptor Interactions Are Required for Treg Stability and Allograft Protection
V. Saxena, W. Piao, L. Li, C. M. Palusckievicz, Y. Xiong, T. Simon, J. S. Bromberg
U Maryland, Baltimore, MD
*Purpose: Regulatory T cells (Treg) restrain allograft rejection through suppressor functions that are dependent upon expression of the transcription factor Foxp3, their proper migration, and…
2019 American Transplant Congress
Phenotypic and Functional Analysis of Non-Activated and Allo-Activated Eomesodermin+ CD8+ T Cells in Humans and Nonhuman Primates
A. Perez Gutierrez¹, A. W. Thomson², D. M. Metes², M. B. Ezzelarab²
¹Transplantation Institute, University of Chicago Medicine, Chicago, IL, ²Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: The T-box transcription factors Eomesodermin (Eomes) and T-bet play a critical role in differentiation and function of CD8+ memory T cells (Tmem). We have…
2019 American Transplant Congress
CD4 T Cell is Essential in an Innate-Immune Driven Ischemia-Reperfusion Injury in Mouse and Human
S. Kageyama¹, K. Kadono¹, H. Hirao¹, K. Nakamura¹, T. Ito², K. J. Dery¹, D. Oncel¹, R. A. Sosa³, E. F. Reed³, F. M. Kaldas², R. W. Busuttil², J. W. Kupiec-Weglinski¹, Y. Zhai¹
¹Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, ²Surgery, Ronald Reagan UCLA Medical Center, Los Angeles, CA, ³Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA
*Purpose: Although CD4 T cells are critical in the mechanism of allograft rejection, little is known about their role in the innate immune-driven ischemia-reperfusion injury…
2019 American Transplant Congress
A Regulatory T Cell-Intrinsic Role for Ikaros in Acquired Transplant Tolerance
R. M. Thomas, L. Wang, W. W. Hancock, A. D. Wells
The Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: Ikaros is a transcriptional repressor encoded by the Ikzf1 gene that was recently identified as the pharmacologic target of thalidomide analogs in successful therapy…
2019 American Transplant Congress
Rcor1 and Regulation of Foxp3+ T-Regulatory Cells In Vitro and In Vivo
Y. Xiong, L. Wang, R. Han, W. W. Hancock
Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: While Foxp3+ T-regulatory (Treg) cells are well established as central players in regulation of allograft acceptance and tolerance, the contributions of several types of…
2019 American Transplant Congress
Cd45rb Mediates Cd8⁺T Cell Persistence In An Allogeneic Heterologous Immune Response
S. M. Krummey, A. B. Morris, M. L. Ford
Emory Transplant Center, Atlanta, GA
*Purpose: Memory T cells primed with microbial antigen can cross-react with alloantigen and mediate graft rejection, a process termed allogeneic heterologous immunity. Human and murine…
2019 American Transplant Congress
Evaluating Allo-Specific CD57⁺ T Cells during Memory and Proliferative Responses
A. Lucander, H. Xu, A. Kirk
Department of Surgery, Duke University, Durham, NC
*Purpose: We have previously identified subsets of CD57+ T cells that are resistant to B7 costimulation blockade (CoB) in kidney transplant recipients. The objective of…
2019 American Transplant Congress
High-Throughput Immune Synapse Detection as a Tool for the Measurement of T Cell Alloreactivity
S. Moshkelgosha, S. C. Juvet
UHN, Toronto, ON, Canada
*Purpose: Measurement of T cell alloreactivity may facilitate a more accurate prediction of graft outcome and the selection of patients for immunosuppression optimization. However, current…
2019 American Transplant Congress
IL-10+ Plasma Cells Are Not Required for Breg Activity and Are Counterbalanced by Novel Pro-Inflammatory Plasma Cells
Q. Ding, Y. Zhou, Z. Song, L. Zeng, D. Rothstein
University of Pittsburgh, Pittsburgh, PA
*Purpose: Classically, B cells differentiate into Ab-secreting plasma cells (PCs; B220lowCD138hiBlimp1+Ig+) providing humoral immunity. B cells can also inhibit or promote immune responses through the…
2019 American Transplant Congress
EBV⁺ PTLD Cell Lines Secrete Exosomes Containing microRNAs That Alter Immune Responses
S. Syed, E. Maloney, A. Hui, O. Martinez, S. Krams
Stanford Univ School of Med, Stanford, CA
*Purpose: Exosomes are nanometric (50-150nm) membrane vesicles that are released, into blood and other body fluids, by most cell types. Exosomes, which are generated from…