Abstracts Archive - Page 56 of 1683 - ATC Abstracts

2022 American Transplant Congress
Superoxide in Cardiac Allografts from Donors After Circulatory Death
M. Urban¹, T. Bruett², K. F. Duncan¹, N. W. Markin³, M. M. Chacon³, M. C. Zimmerman⁴
¹Department of Surgery. Division of Cardiothoracic Surgery, University of Nebraska Medical Center, Omaha, NE, ²College of Medicine. Department of Cellular and Integtrative Physiology., University of Nebraska Medical Center, Omaha, NE, ³Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE
*Purpose: Quality of cardiac allografts from donors after circulatory death (DCD) is adversely impacted by warm ischemia and subsequent reperfusion during organ resuscitation. Post-transplant myocardial…
2022 American Transplant Congress
Dynapenia Among Kidney Transplant Candidates and Recipients in the United States
A. S. Nalatwad¹, X. Chen¹, N. M. Chu¹, S. P. Norman², D. L. Segev¹, M. McAdams-Demarco¹
¹Epidemiology Research Group in Organ Transplantation, Johns Hopkins University School of Medicine, Baltimore, MD, ²Univ of Michigan Medical Ctr, Ann Arbor, MI
*Purpose: Among Kidney Transplant (KT) patients, sarcopenia, loss of muscle mass, is prevalent and has been associated with post-KT mortality. The burden of dynapenia, an…
2022 American Transplant Congress
Comparison of Cardiovascular Events by Different Types of Lipid-Lowering Drugs in Kidney Transplant Recipients
S. Bae¹, J. Ahn², M. A. Schnitzler³, K. Lentine⁴, D. Segev¹, M. McAdams-DeMarco¹
¹Johns Hopkins University, Baltimore, MD, ²SOM, Johns Hopkins University, Baltimore, MD, ³Surgery, Saint Louis University, St. Louis, MO, ⁴Saint Louis University, St. Louis, MO
*Purpose: Lipid-lowering drugs, notably statins, are one of the most widely prescribed drug classes in kidney transplant (KT) recipients. These drugs have substantially different mechanisms…
2022 American Transplant Congress
Induction Immunosuppression Does Not Worsen Tumor Recurrence After Liver Transplantation for T2 Hepatocellular Carcinoma and May Allow for Decreased Mortality
C. Durkin¹, T. Bittermann¹, D. E. Schaubel²
¹Gastroenterology, University of Pennsylvania, Philadelphia, PA, ²Biostatistics, University of Pennsylvania, Philadelphia, PA
*Purpose: Prior studies have suggested that induction therapy leads to worse outcomes after liver transplantation (LT) for hepatocellular carcinoma (HCC). This study evaluated the impact…
2022 American Transplant Congress
Inhibition of ITGB5 Protects Hepatocytes from Ischemia Reperfusion Injury
M. Dogan¹, S. Naik¹, C. Watkins¹, A. Bajwa¹, V. Mas², J. Eason³, C. Kuscu¹, C. Kuscu¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²Surgery, University of Maryland, Baltimore, MD, ³University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: Liver transplantation is the best treatment option for patients with end-stage liver disease (ESLD). Despite the increasing interest to the machine reperfusion, cold preservation…
2022 American Transplant Congress
Can We Predict Progression of Potential Donation After Cardiac Death Donors (DCD) Using DonorNet?
Y. Bababekov¹, A. Yule¹, H. Moore¹, R. Choudhury², C. Hertert³, T. Pshak⁴, T. Nydam⁵, B. Kaplan¹, E. Pomfret¹, J. Pomposelli⁵
¹Transplant Surgery, University of Colorado, Aurora, CO, ²University of Colorado Hospital, Denver, CO, ³Donor Alliance, Denver, CO, ⁴University of Colorado, Denver, CO, ⁵University of Colorado, Aurora, CO
*Purpose: DCD utilization of livers is limited by unpredictability of progression, perceived worse outcome, and costs related to deployment of resources. We aimed to predict…
2022 American Transplant Congress
Humoral Response After a Third Dose of Sars-CoV-2 mRNA Vaccine in Transplant Recipients
A. E. Woolley, N. Sharma, G. Zhou, A. Kim, E. Ryan, M. Joyce, H. Goldberg, M. Givertz, M. Mehra, E. Woodcome, V. Durney, S. Marshall, K. Townsend, A. Coppolino, S. Tullius, S. Malek, H. Mallidi, L. Baden, A. Chandraker
Brigham & Women's Hospital, Boston, MA
*Purpose: Prior studies demonstrated an increased immune response post-3rd COVID-19 vaccine dose when given 1-month post-2nd dose in solid organ transplant recipients (SOT). This study…
2022 American Transplant Congress
HDAC6 Inhibition Mediated Protection from Hepatic Ischemia Reperfusion is Associated with Preserved Glutathione Levels
C. OBrien¹, P. Hernandez¹, S. Concors², Z. Wang¹, G. Ge³, A. Kozikowski⁴, W. Hancock⁵, M. Levine²
¹Surgery, University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Surgery, University of Pensylvania, Philadelphia, PA, ⁴College of Pharmacy, University of Illinois at Chicago, Chicago, IL, ⁵Childrens Hospital of Philadelphia, Philadelphia, PA
*Purpose: Liver Ischemia reperfusion injury (IRI) and Acetaminophen (APAP) toxicity are important causes of acute liver failure in the United States, that lack effective therapy.…
2022 American Transplant Congress
A Multicenter Randomized Controlled Trial To Compare The Efficacy Of Ex-vivo Machine Perfusion With Static Cold Storage In Human Liver Transplantation: The University Of Maryland Experience
J. Avruch¹, N. Goussous², S. Malik¹, M. Pinedo¹, R. Meier¹, C. Bhati¹, D. Maluf¹, R. Barth³, J. Alvarez-Casas¹
¹Transplant Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Transplant Surgery, University of California Davis Health, Davis, CA, ³University of Chicago, Chicago, IL
*Purpose: There is accumulating clinical evidence of the benefit of normothermic ex-vivo machine perfusion (NMP) compared with traditional static cold storage of liver allografts prior…
2022 American Transplant Congress
The SHELTER Trial of Transplanting Donor Hepatitis C Virus RNA+ Lungs Into Uninfected Recipients
V. Potluri¹, P. Reese¹, S. Prenner¹, H. Mentch¹, D. Goldberg², T. Claridge¹, J. Smith¹, C. Gentile¹, V. Van Deerlin¹, R. Reddy¹, T. Fallah¹, C. Bermudez¹, M. Crespo¹, J. Diamond¹
¹University of Pennsylvania, Philadelphia, PA, ²University of Miami, Miami, FL
*Purpose: The advent of direct acting antiviral therapy has motivated centers to transplant lungs from donors with hepatitis C virus infection (HCV-RNA+) into uninfected recipients.…