Abstracts Archive - Page 551 of 1683 - ATC Abstracts

2020 American Transplant Congress
Circulatory Extracellular Vesicles from Lung Allograft Recipients with Chronic Lung Allograft Dysfunction Can Induce LKB1 Dependent Epithelial-Mesenchymal Transition
M. Rahman, S. Angara, A. Arjuna, M. Smith, R. Bremner, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Extracellular vesicles (EVs) play important role in physiological and pathological conditions. Recently we demonstrated that circulating exosomes (EVs) with lung self-antigens (SAgs) play important…
2020 American Transplant Congress
Single-Cell RNA Sequencing to Assess the Effect of IL-6 Receptor Blockade in Kidney Transplantation
A. Zarinsefat, P. Rashmi, A. Da Silva, T. Sigdel, S. Chandran, Q. Tang, J. Ye, F. Vincenti, M. Sarwal
University of California San Francisco, San Francisco, CA
*Purpose: Prospective randomized study of IL-6R blockade with Tocilizumab for treatment of subclinical inflammation (SCI) in renal transplantation, reveals unique profiles of resting and stimulated…
2020 American Transplant Congress
Extracellular Vesicles Mediate Endothelial to Mesenchymal Transition and Tubular Senescence in Renal Antibody- Mediated Rejection by Inducing Complement Activation
G. Castellano, R. Franzin, A. Stasi, C. Divella, G. Merlotti, M. Quaglia, F. Sallustio, G. Stallone, V. Cantaluppi, L. Gesualdo
Emergency and Organ Transplantation, University of Bari, Bari, Italy
*Purpose: EVs (Extracellular vesicles), circulating microparticles able to mediate cell-to cell communication, are emerging as pivotal in different kidney diseases. Renal Antibody-Mediated Rejection (AMR) is…
2020 American Transplant Congress
Noninvasive Imaging of CD122+ T Cells via Immuno-PET for Detection of Acute Cellular Rejection
A. J. Matar¹, B. P. Lovasik¹, D. Vanover², L. Rotolo², Y. Dong¹, D. A. Faber¹, D. V. Mathews¹, W. H. Kitchens¹, P. Santangelo², A. B. Adams¹
¹Surgery and Transplantation, Emory University, Atlanta, GA, ²Biomedical Engineering, Georgia Tech, Atlanta, GA
*Purpose: Acute cellular rejection (ACR) remains a clinically important problem following organ transplantation. Clinically, suspicion of ACR is dependent upon serum laboratory values, and diagnosis…
2020 American Transplant Congress
A Monocyte-Derived MicroRNA Signature for Antibody-Mediated Rejection in Kidney Transplantation
C. Tinel¹, B. Lamarthée¹, F. Von Tokarski¹, M. Rabant², C. Legendre¹, W. Gwinner³, M. Naesens⁴, P. Marquet⁵, D. Anglicheau¹
¹Kidney Transplantation, Inserm U1151, Necker Hospital, Paris, France, ²Pathology, Necker Hospital, Paris, France, ³Nephrology, Hannover Medical School, Hannover, Germany, ⁴Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium, ⁵Nephrology, Dialysis and Transplantation, Inserm U850, Limoges University Hospital, Limoges, France
*Purpose: MicroRNAs (miRNAs) are small noncoding RNAs which regulate mRNA expression at the posttranscriptional level. We investigated blood miRNAs as non-invasive biomarkers in kidney transplantation…
2020 American Transplant Congress
High Frequencies of Donor-Derived Memory T and NK Cells in the Blood of Lung Transplant Recipients May Contribute to Protection from Chronic Lung Allograft Dysfunction
R. Bellmàs Sanz¹, A. Hitz¹, B. Wiegmann², K. Bläsing¹, F. Ius², W. Sommer², J. Kühne¹, L. Horn¹, A. Knöfel², I. Tudorache², A. Haverich², D. Jonigk³, G. Warnecke², C. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany, ³Institute of Pathology, Hannover Medical School MHH, Hannover, Germany
*Purpose: After lung transplantation (LuTx), a transient chimerism of donor cells exists in the blood of recipients due to the migration of lymphocytes from the…
2020 American Transplant Congress
Imaging OX40+Alloreactive T Cells Provides Early Warning of Organ Transplant Rejection
T. Hirai¹, A. Mayer², T. W. Nobashi², Z. Xiao², T. Udagawa³, K. Seo⁴, F. Simonetta⁵, J. Baker⁵, A. Cheng³, S. S. Gambhir², R. S. Negrin⁵
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Department of Radiology, Stanford University, Stanford, CA, ³Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, ⁴Division of Cardiovascular Medicine, Stanford University, Stanford, CA, ⁵Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA
*Purpose: Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. Immuno positron emission tomography (immunoPET) utilizing…
2020 American Transplant Congress
Single Cell RNA Transcriptomics to Further the Precision Transplantation Medicine Approaches in Kidney Allograft Recipients
H. Suryawanshi, H. Yang, M. Lubetzky, S. Seshan, T. Tuschl, M. Suthanthiran, T. Muthukumar
Weill Cornell Medicine, New York, NY
*Purpose: Test the hypothesis that single cell RNA transcriptomics will further the precision transplantation medicine approaches and address important conundrums in clinical transplantation.*Methods: We studied…
2020 American Transplant Congress
Identification of Molecular Markers for Liver Cirrhosis (NASH) by Single-Nucleus RNA Sequencing
C. Kuscu¹, A. Mouhammed², C. Kuscu³, A. R. Wolen³, J. D. Eason³, D. Maluf³, V. Mas³
¹Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN, ²Bioinformatics, University of Tennessee Health Science Center, Memphis, TN, ³Department of Surgery, University of Tennessee Health Science Center, Memphis, TN
*Purpose: Non-alcoholic fatty liver disease (NAFLD) is a progressive disease and it constitutes a significant portion of the chronic liver diseases that affected more than…
2020 American Transplant Congress
TRANSFORM Study (NCT01950819): Application of the Ibox Clinical Trial Simulation Tool to Project Long-Term Kidney Allograft Outcome
G. Divard¹, O. Aubert¹, M. Raynaud¹, J. Pascual², F. Vincenti³, P. Bernhardt⁴, C. Legendre¹, A. Loupy¹, .. on behalf of TRANSFORM Investigators⁵
¹INSERM U970, Paris Transplant Group, Paris, France, ²Department of Nephrology, Hospital del Mar/Universitat Autònoma de Barcelona, Barcelona, Spain, ³Department of Surgery/Kidney Transplant Service, University of California, San Francisco, CA, ⁴Research and Development, Novartis Pharma AG, Basel, Switzerland, ⁵TRANSFORM Investigators, Basel, Switzerland
*Purpose: The development of pharmaceutical agents in transplantation is currently limited by long waits for hard endpoints. We sought to use a risk stratification system…