2020 American Transplant Congress
Utilization of Mechanical Circulatory Support Devices and Impact on Outcomes in the New Heart Allocation System: An Analysis of the UNOS Registry
*Purpose: In October 2018, a new heart transplantation allocation system was put into effect with the intent of better stratifying the most medically urgent candidates,…2020 American Transplant Congress
Successful Heart Utilization and Outcomes with Long-Distance Transport of Deceased Donor Hearts: One Large Organ Procurement Organization’s Five-Year Experience
LifeCenter Northwest, Bellevue, WA
*Purpose: Long-distance transport of deceased donor hearts has been associated with reduced organ utilization rates and risk of inferior outcomes. One U.S. Organ Procurement Organization’s…2020 American Transplant Congress
Effects of Donor Specific Antibodies in Intestinal/Multivisceral Transplant Recipients
1University Health System, San Antonio, TX, 2Nebraska Medicine, Omaha, NE
*Purpose: Evaluate the effects of donor specific antibodies (DSAs) on outcomes in post-intestinal/multivisceral (MV) transplant patients and describe the presentation of DSAs post-transplant.*Methods: This single-center…2020 American Transplant Congress
Role of B-Cell Subsets in Allograft Rejection in Intestinal Transplantation
Transplant Institute, MedStar Georgetown University, Washington, DC
*Purpose: While B-cells contribute to allograft rejection by presenting antigens to T-cells and by producing donor-specific antibodies (DSAs) and various cytokines, their pathophysiology in transplant…2020 American Transplant Congress
Intestinal Retransplantation: Survival Outcomes Similar to Primary Transplantation
University of Nebraska Medical Center, Omaha, NE
*Purpose: Isolated and multivisceral intestinal transplantation is indicated for patients with life threatening complications of intestinal failure. Intestinal retransplantation has been performed in select intestinal…2020 American Transplant Congress
Role of APC Subsets in Rejection and Graft-Versus-Host-Disease in Intestinal Transplantation
Transplant Institute, MedStar Georgetown University, Washington, DC
*Purpose: Intestinal transplantation (ITx) is arguably the most immunogenic and complex organ transplantation, often accompanied with high rates of allograft rejection (AR) and graft-versus-host disease…2020 American Transplant Congress
A Nonhuman Primate Model of Intestinal Transplantation – Technical Aspects and Early Outcomes
*Purpose: Intestinal transplantation (IT) is the treatment of choice for patients with irreversible intestinal failure that experience complications from total parenteral nutrition. Long-term outcomes after…2020 American Transplant Congress
Crispr-Based Diagnostics for Rejection and Opportunistic Infection Detection in Kidney Transplantation
*Purpose: There is an unmet need in transplantation to identify allograft injury non-invasively. More than 50% of patients with kidney transplants lose their grafts within…2020 American Transplant Congress
Automated Monitoring of Four Urinary Biomarkers in Routine Surveillance Identifies Patients at Low and High Risk of Renal Allograft Injury
*Purpose: Surveillance renal biopsy data indicate that up to 36% of clinically stable kidney allograft recipients have subclinical rejection, emphasizing the need to implement automated…2020 American Transplant Congress
Targeted Urine Metabolomics for Monitoring Renal Allograft Injury and Immunosuppression
University of California San Francisco, San Francisco, CA
*Purpose: The purpose of this study was to apply high-throughput metabolomics and machine learning to identify surrogate urine metabolite biomarkers for acute rejection vs. BK…
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