Abstracts Archive - Page 542 of 1683 - ATC Abstracts

2020 American Transplant Congress
Predominant Role of Microvascular Injury and Rarefaction Function as Drivers of Progressive Renal Damage and Fibrosis Post Mild and Severe Acute Ischemia-Reperfusion Injury
S. Lan¹, B. Yang¹, J. Sabo-Vatasescu², M. Bourgault², A. Karakeussian-Rimbaud³, J. Turgeon³, S. Qi¹, N. Patey⁴, M. Dieudé⁵, M. Hébert¹
¹Medicine Faculty, CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada, ²CRCHUM, Montreal, QC, Canada, ³CRCHUM, CDTRP, Montreal, QC, Canada, ⁴Medicine Faculty, CRCHUM, Saint Justine Hospital, University of Montreal, Montreal, QC, Canada, ⁵CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Here, we characterize the different cell deaths in tubular and microvascular compartments…
2020 American Transplant Congress
Kidney Alkalization Increases Macula Densa NOS1β Expression and Improves Transplanted Renal Graft Function
J. Buggs¹, J. Zhang², J. Wei², L. Wang²
¹Transplant Surgery, Tampa General Hospital, Tampa, FL, ²Molecular Pharmacology & Physiology, University of South Florida, Morsani College of Medicine, Tampa, FL
*Purpose: Ischemia-reperfusion injury (IRI) is a major survival hurdle with kidney transplantation (KTX). Currently, no effective strategies for the prevention and treatment of IRI during…
2020 American Transplant Congress
Gasdermin-D Mutation is Protective against Renal Ischemia Reperfusion Injury
J. Li, N. Rogers, S. Alexander
Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, Australia
*Purpose: Pyroptosis, a pro-inflammatory form of cell death, is dependent on membrane pore formation through the assembly of cleaved Gasdermin-D molecules. We hypothesized that this…
2020 American Transplant Congress
Proteomics and Metabolomics Technologies Reveal the Effect of Oxygen in Hypothermic Machine Perfusion to Alleviate Donation after Circulatory Death Liver Injury
X. Zeng¹, X. Fan², Y. Wang², Q. Xia¹, J. Liu¹, H. Li¹, Q. Ye², Z. Wang¹
¹Department of Urology, Union Hospital, Affiliated TongJi Medical College, Huazhong University of Science & Technology, Wuhan, China, ²Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Wuhan, China
*Purpose: To compare the effects of oxygenated and nitrogenated hypothermic machine perfusion on the preservation of donation after circulatory death (DCD) livers, and to explore…
2020 American Transplant Congress
Factors Associated with Renal Graft Loss in Simultaneous Kidney-Heart Transplant Recipients in the UNOS Cohort
K. A. Agarwal¹, H. Patel¹, K. Almonte², F. Cardarelli¹, N. Agrawal¹
¹Nephrology, Beth Israel Deaconess Medical Center, Boston, MA, ²Medicine, Mount Auburn Hospital, Cambridge, MA
*Purpose: Simultaneous kidney and heart transplants (SKHT) are employed for patients with both end-stage heart failure and severely impaired kidney function. Renal outcomes in such…
2020 American Transplant Congress
10-Year Experience Transplanting Very Highly Sensitized Patients with End Stage Renal Disease
J. Diaz¹, J. Kennedy², S. Chinnakotla³, P. Verghese⁴
¹Department of Surgery, University of Minnesota, Saint Paul, MN, ²University of Minnesota, Minneapolis, MN, ³Department of Surgery, University of Minnesota, Minneapolis, MN, ⁴Department of Pediatrics, Division of Pediatric Nephrology, University of Minnesota, Minneapolis, MN
*Purpose: Very highly sensitized (VHS) individuals (calculated reactive antigen (cPRA) ≥ 95%) have increased rejection risk which negatively impacts kidney transplant outcomes. Multiple strategies have…
2020 American Transplant Congress
Uromodulin to Osteopontin Ratio in Deceased Donor Urine is Associated with Kidney Graft Outcomes
S. G. Mansour¹, C. Liu², Y. Jia², P. Reese³, I. Hall⁴, T. El-Achkar⁵, K. LaFavers⁵, W. Obeid², M. Thangamani⁶, A. Rosenberg², M. Doshi⁷, E. Akalin⁸, J. Bromberg⁹, M. Harhay¹⁰, S. Mohan¹¹, B. Schröppel¹², P. Daneshpajouhnejad², P. Singh¹³, F. Weng¹⁴, H. Thiessen-Philbrook², C. Parikh²
¹Yale, New Haven, CT, ²Johns Hopkins, Baltimore, MD, ³UPenn, Philadelphia, PA, ⁴Univ of Utah, Salt Lake City, UT, ⁵Indiana Univ, Bloomington, IN, ⁶Cornell, New York, NY, ⁷Univ of Michigan, Ann Arbor, MI, ⁸Montefiore, Bronx, NY, ⁹Univ of Maryland, College Park, MD, ¹⁰Drexel, Philadelphia, PA, ¹¹Columbia, NY, NY, ¹²Univ Hosp, Ulm, Germany, ¹³Thomas Jefferson, Philadelphia, PA, ¹⁴St. Barnabas, Livingston, NJ
*Purpose: Deceased-donor kidneys often experience extensive injury, activating adaptive and maladaptive pathways. While these adaptive and maladaptive mechanisms are initiated in donor kidneys prior to…
2020 American Transplant Congress
HLA-DR/DQ Molecular Mismatch Dictates Early Risk of De Novo Donor-Specific Antibody Development and Offers a Personalized Approach to Immunosuppression Management in Kidney Transplantation
S. Davis¹, C. Wiebe², K. Campbell¹, C. Anobile³, M. Aubrey³, A. Wiseman¹, E. Pomfret¹, P. Nickerson², J. Cooper¹
¹University of Colorado, Aurora, CO, ²University of Manitoba, Winnipeg, MB, Canada, ³Clinimmune, Aurora, CO
*Purpose: Clinicians have few tools to predict the risk of alloimmune injury in a patient undergoing renal transplantation, as traditional demographic or clinical variables lack…
2020 American Transplant Congress
Identification of the dnDSA Inducing HLA Mismatches Across Multiple Renal Transplant Centers: A 3-Year Longitudinal Analysis of >11,000 HLA Mismatches in 2271 Patients
J. M. Brennan¹, M. D. Stegall², C. A. Schinstock², R. L. Heilman³, L. M. Rebellato⁴, M. D. Samaniego-Picota⁵, D. Lesser⁴, M. J. Ghandi², J. L. Beaumont¹, M. J. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²Mayo Clinic, Rochester, MN, ³Mayo Clinic, Phoenix, AZ, ⁴East Carolina University, Greenville, NC, ⁵Henry Ford Transplant Institute, Detroit, MI
*Purpose: The presence of a mismatch (MM) between donor and recipient HLA does not always lead to the patient developing a de novo donor-specific anti-HLA…
2020 American Transplant Congress
Single Cell Profiling of PBMC Identifies Immune Populations Associated with High Risk of Early Acute Rejection
W. Zhang, S. Farouk, Z. Sun, W. Huang, Z. Yi, J. Fu, C. Wei, M. Fribourg-Casajuana, C. He, P. Cravedi, B. Murphy
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Our previous transcriptomic analysis of pre-transplant peripheral blood revealed a 23-gene set predictive of early acute rejection (EAR) post kidney transplant (JCI Insight, 2019).…