Abstracts Archive - Page 538 of 1683 - ATC Abstracts

2020 American Transplant Congress
An Optimized Integrative Model Using Urinary Chemokines for Noninvasive Diagnosis of Acute Allograft Rejection
C. Tinel¹, A. Devresse¹, A. Vermorel¹, D. Marx², S. Caillard², C. Legendre¹, M. Rabant³, D. Anglicheau¹
¹Nephrology and Kidney Transplantation, Inserm U1151, Necker Hospital, Paris, France, ²Nephrology and Kidney Transplantation, Strasbourg University Hospital, Strasbourg, France, ³Pathology, Necker Hospital, Paris, France
*Purpose: The aim of this study was to optimize the performance of urinary chemokines C-X-C motif ligand (CXCL) 9 and CXCL10 as noninvasive diagnostic markers…
2020 American Transplant Congress
Trajectories of Glomerular Filtration Rate and Progression to End Stage Renal Disease after Kidney Transplantation
M. Raynaud¹, O. Aubert¹, P. Reese², M. Naesens³, D. Glotz¹, C. Legendre¹, S. Jordan⁴, M. Stegall⁵, D. Segev⁶, C. Lefaucheur¹, A. Loupy, On behalf of the study NCT03474003¹
¹Paris Transplant Group, Paris, France, ²University of Pennsylvania, Philadelphia, PA, ³Department of Transplantation, Leuven, Belgium, ⁴Cedars Sinai, Los Angeles, CA, ⁵Mayo Clinic, Rochester, MN, ⁶Johns Hopkins, Baltimore, MD
*Purpose: Although the current gold standard of monitoring kidney transplant function relies on glomerular filtration rate (GFR) assessment, little is known about GFR trajectories after…
2020 American Transplant Congress
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
R. El Fekih¹, A. Alghamdi¹, J. Hurley², C. Coticchia², J. Choi¹, H. Allos¹, S. Eskandari¹, S. Bentink², V. Tadigotla², L. Riella¹, J. Markmann³, K. Safa³, R. Formica⁴, J. Skog², J. Azzi¹
¹Medecine, Brigham and Women's Hospital, Boston, MA, ²Exosome Diagnostics Inc., Waltham, MA, ³Massachusetts General Hospital, Boston, MA, ⁴Yale School of Medecine, New Haven, CT
*Purpose: Monitoring kidney transplant rejection by repeated biopsies might result in increased procedural complications and cost. Exosomes are nanometer-sized vesicles released by cells carrying trans…
2020 American Transplant Congress
Multidimensional System to Dynamically Predict Graft Survival after Kidney Transplantation
M. Raynaud¹, O. Aubert¹, S. Jordan², M. Stegall³, J. Friedewald⁴, D. Glotz¹, C. Legendre¹, D. Segev⁵, C. Lefaucheur¹, A. Loupy, On behalf of the study NCT03474003¹
¹Paris Transplant Group, Paris, France, ²Cedars Sinai, Los Angeles, CA, ³Mayo Clinic, Rochester, MN, ⁴Northwestern University, Chicago, IL, ⁵Johns Hopkins, Baltimore, MD
*Purpose: Current prediction systems of kidney-graft loss do not integrate the dynamic effect of parameters assessed over the time course of kidney recipients. Recent dynamic…
2020 American Transplant Congress
Molecular Profiles of Injury in Heart Transplant Allograft: Relationship to Rejection, Ejection Fraction, and Survival
P. Halloran¹, J. Reeve², &. the INTERHEART Study Group³
¹University of Alberta, Edmonton, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: In previous studies we used microarray analysis of gene expression to identify rejection in heart transplant endomyocardial biopsies, and found that this also revealed…
2020 American Transplant Congress
Prolonged Multitransgenic Pig Lung Survival with Attenuated Pulmonary Vascular Resistance Rise During Human Blood Perfusion
M. R. Connolly¹, L. Burdorf¹, S. Pratts¹, B. Cerel¹, Z. Abady¹, W. Quin², Y. Kan², J. Layer², M. Youd², W. Westlin², L. Yang², A. Azimzadeh¹, R. N. Pierson III¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²eGenesis, Cambridge, MA
*Purpose: Physiologic behavior of porcine lungs with multiple xeno-targeted genetic modifications, Pig 2.0, have not previously been evaluated.*Methods: Eight pairs of lungs from Pig 2.0…
2020 American Transplant Congress
Coagulation and Cd46 Transgene Modification in Neonatal Porcine Islet Xenotransplantation
M. Song, Z. Fitch, K. Samy, Q. Gao, R. P. Davis, F. Leopard, R. Schmitz, N. Huffman, G. Devi, B. Collins, A. D. Kirk
Surgery, Duke University, Durham, NC
*Purpose: Vascular thrombosis is a potential cause for early intraportal xeno-islet loss. To better understand the relationship between coagulation and inflammation in early xeno-islet transplantation,…
2020 American Transplant Congress
In-Vivo Application of Ides (Imlifidase) in Nonhuman Primates Results in Xenoreactive Desensitization: A Novel Anti-Humoral Therapy
B. P. Lovasik¹, A. J. Matar¹, D. A. Faber¹, D. V. Mathews¹, C. Breeden¹, S. C. Kim¹, A. J. Tector², A. Robertson³, C. Kjellman³, A. B. Adams¹
¹Emory University School of Medicine, Atlanta, GA, ²University of Miami, Miami, FL, ³HANSA Biopharma, Lund, Sweden
*Purpose: Antibody-mediated rejection is a formidable barrier to xenograft survival. A novel anti-humoral IdeS therapy, which cleaves serum IgG, represents a promising therapy to reduce…
2020 American Transplant Congress
Molecular Features of HLA Mismatches as Predictors of De Novo DSA Development: A Single Center Experience
V. Jucaud¹, L. Rebellato², K. Briley², C. Haisch², S. Kendrick³, H. Jones³, K. Mclawhorn³, D. Leeser², M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²East Carolina University, Greenville, NC, ³Eastern Nephrology Associates, Greenville, NC
*Purpose: Several molecular features (MoFs) of HLA mismatches (MMs) are currently used to predict the development of de novo donor-specific anti-HLA antibodies (dnDSA). The purpose…
2020 American Transplant Congress
Low HLA Class I Epitope Mismatch Associated with Improved Pancreas Graft Survival in Simultaneous Pancreas-Kidney Transplantation
J. M. Ladowski, M. Romine, D. Kloda, C. Young, J. Locke, V. Hauptfeld-Dolejsek, J. Houp
University of Alabama-Birmingham, Birmingham, AL
*Purpose: Antibody-mediated rejection remains the principal cause of allotransplant graft failure. Human leukocyte antigen (HLA) matching between donor and recipients significantly reduces the risk of…