Abstracts Archive - Page 535 of 1683 - ATC Abstracts

2020 American Transplant Congress
Broader Distribution of Kidneys Not Projected to Systematically Favor “Low” Performing OPOs
A. Wilk¹, S. Gustafson², D. Stewart¹, N. Salkowski², D. Zaun², J. Snyder²
¹UNOS, Richmond, VA, ²Hennepin Healthcare Research Institute, Minneapolis, MN
*Purpose: In August 2019, the OPTN Kidney (KI) Transplantation Committee put forth a proposal for public comment to replace DSA and region from KI allocation…
2020 American Transplant Congress
The Impact of Multi-Organ Transplant Allocation Priority on Wait-Listed Isolated Kidney Transplant Candidates
S. Westphal¹, E. Langewisch¹, A. Robinson², A. Wilk², T. Plumb¹, R. Mullane¹, S. Merani¹, A. Hoffman¹, A. Maskin¹, C. Miles¹
¹University of Nebraska Medical Center, Omaha, NE, ²United Network for Organ Sharing, Richmond, VA
*Purpose: Multi-Organ Transplant (MOT) candidates involving a kidney receive higher allocation priority than kidney alone transplant (KAT) candidates. The increasing utilization of MOT has the…
2020 American Transplant Congress
Racial Differences in Acceptance of Public Health Service (PHS) Increased Risk Kidneys and Hepatitis C (HCV) Nat Positive Kidneys
K. Atiemo, S. Giusti, A. Paramesh, M. Killackey, H. Jeon
Tulane University, New Orleans, LA
*Purpose: PHS increased risk kidneys and HCV NAT positive kidneys represent a significant proportion of the donor pool however, acceptance demands explicit patient consent that…
2020 American Transplant Congress
Missing Self Increases the Incidence of Microvascular Inflammation after Kidney Transplantation
J. Callemeyn¹, A. Senev², M. Coemans¹, E. Lerut³, B. Sprangers¹, D. Kuypers¹, A. Koenig⁴, O. Thaunat⁴, M. Emonds², M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Histocompatibility and Immunogenetics Laboratory, Red Cross-Flanders, Mechelen, Belgium, ³Imaging and Pathology, KU Leuven, Leuven, Belgium, ⁴INSERM U1111, Université Claude Bernard Lyon I, Lyon, France
*Purpose: Anti-HLA donor-specific antibodies (HLA-DSA) are often absent in serum of kidney allograft recipients with biopsies demonstrating microvascular inflammation (MVI), the histological hallmark of antibody-mediated…
2020 American Transplant Congress
Intimal Arteritis in Association with Microvascular Inflammation Leads to Inferior Graft Survival Regardless DSA
M. Novotny¹, E. Honsova², O. Viklicky¹
¹Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
*Purpose: Intimal arteritis belongs between diagnostic criteria of both antibody-mediated rejection (AMR) and T cell-mediated vascular rejection (TCMRV). Patients with intimal arteritis must be assessed…
2020 American Transplant Congress
The Banff Classification of Antibody-Mediated Rejection in Kidney Allografts: Comparison of Predictive Performance for Allograft Failure in Previous and Current Editions
J. Callemeyn¹, H. Ameye¹, M. Coemans¹, A. Senev², E. Lerut³, B. Sprangers¹, D. Kuypers¹, M. Emonds², M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Histocompatibility and Immunogenetics Laboratory, Red Cross-Flanders, Mechelen, Belgium, ³Imaging and Pathology, KU Leuven, Leuven, Belgium
*Purpose: Since its introduction in 2001, the Banff classification for antibody-mediated rejection (ABMR) has undergone significant changes, mainly by inclusion of C4d-negative ABMR in 2013…
2020 American Transplant Congress
CD56^DimCD16^Bright NK Cells from Kidney Transplant Recipients with Antibody-Mediated Rejection Display Increased Proliferation, Self-Renewal, Pro-Inflammatory and Cytotoxic Profile
E. A. Bailly¹, K. Louis¹, C. Macedo¹, B. Ramaswami¹, M. Lucas¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Université de Paris, France
*Purpose: Contribution of NK cells to antibody-mediated rejection (ABMR) injuries have recently been highlighted through transcriptomic analysis and immunohistochemistry of kidney and heart allograft biopsies.…
2020 American Transplant Congress
Novel Treatment of Acute Antibody-Mediated Rejection in a Nonhuman Primate Model of Kidney Allotransplantation
R. Schmitz¹, Z. W. Fitch¹, A. Y. Choi¹, M. Manook¹, J. Yoon¹, J. D. Lambris², J. Kwun¹, S. J. Knechtle¹
¹Department of Surgery, Duke University Medical Center, Durham, NC, ²Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: One third of sensitized, HLA-incompatible transplant recipients experience acute antibody mediated rejection (AMR) with limited treatment options. We tested a novel treatment strategy for…
2020 American Transplant Congress
Kidney Paired Donation Outcomes among High PRA Recipients
A. Thomas¹, A. Shaffer², M. Henderson², D. Segev²
¹University of North Carolina, Chapel Hill, NC, ²Johns Hopkins, Baltimore, MD
*Purpose: Kidney paired donation (KPD) accounts for an increasing amount of living donor transplants in the US. Previous studies have shown equivalent outcomes between transplants…
2020 American Transplant Congress
Compatible Pairs- Providingan Option to Upgrade
V. Chipman¹, M. Cooper², S. Flechner³, G. Hil⁴, D. Leeser⁵, D. Mandelbrot⁶, M. Ronin⁴, D. Segev⁷, S. Syed⁸, A. Thomas⁹, A. Waterman¹⁰, G. R. Roll¹¹
¹Kidney Transplant, UCSF, San Francisco, CA, ²Georgertown, Washington, DC, ³Cleavland Clinic, Cleavland, OH, ⁴NKR, Babylon, NY, ⁵East Carolina Univ, Greenville, NC, ⁶University of Wisconsin, Madison, WI, ⁷Johns Hopkins, Boltimore, MD, ⁸UCSF, San Francisco, CA, ⁹Johns Hopkins, Baltimore, MD, ¹⁰UCLA and Terasaki Research Institute, Los Angeles, CA, ¹¹Surgery, Division of Transplant, UCSF, San Francisco, CA
*Purpose: Compatible pairs (CPs) can enter an exchange program instead of donating directly. These pairs increase transplants (txp) by providing additional donors within an exchange…