ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Apoptotic Exosome-Like Vesicles Aggravate Inflammation and Renal Injury After Ischemia-Reperfusion

    I. Kaci1, S. Lan1, H. Kim1, A. Karakeussian Rimbaud1, F. Migneault1, J. Turgeon1, N. Patey2, M. Dieudé1, M. Hébert1

    1Research Centre, Centre hospitalier de l’Université de Montréal, Montreal, QC, Canada, 2Research Centre, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada

    *Purpose: Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) and chronic kidney disease (CKD). Damage to microvascular peritubular capillaries (PTC) is…
  • 2022 American Transplant Congress

    Post-Kidney Transplant Body Mass Index Trajectories Are Associated with Graft Loss and Mortality

    Y. Liu1, V. Bendersky1, X. Chen1, M. Harhay2, D. Segev1, M. McAdams-DeMarco1

    1Johns Hopkins University, Baltimore, MD, 2Drexel University, Philadelphia, PA

    *Purpose: Early post-kidney transplantation (KT) changes in physiology, medications, and health stressors likely impact body mass index (BMI). Hence, we sought to estimate trajectories of…
  • 2022 American Transplant Congress

    Impact of Total Parenteral Nutrition on Donor Kidneys During Oxygenated Preservation at 22ºC Ex Vivo

    P. Luke1, A. Jackson2, A. Ruthirakanthan2, S. Juriasingani2, M. Levine1, L. Jiang2, R. Patel2, M. Richard-Mohamed1, S. Forrest1, A. Sener1, R. N. Bhattacharjee1

    1London Health Sciences Centre, London, ON, Canada, 2Western University, London, ON, Canada

    *Purpose: Recent studies have shown that ex vivo preservation at 37 º C can reduce kidney injury compared to current clinical practice. However, to mitigate…
  • 2022 American Transplant Congress

    HDAC6 Inhibition Mediated Protection from Hepatic Ischemia Reperfusion is Associated with Preserved Glutathione Levels

    C. OBrien1, P. Hernandez1, S. Concors2, Z. Wang1, G. Ge3, A. Kozikowski4, W. Hancock5, M. Levine2

    1Surgery, University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3Surgery, University of Pensylvania, Philadelphia, PA, 4College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 5Childrens Hospital of Philadelphia, Philadelphia, PA

    *Purpose: Liver Ischemia reperfusion injury (IRI) and Acetaminophen (APAP) toxicity are important causes of acute liver failure in the United States, that lack effective therapy.…
  • 2022 American Transplant Congress

    Impact of Cold Ischemia Times on 1 Year Kidney Transplant Outcomes

    T. Fletchinger, L. Burdine

    Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR

    *Purpose: Recent organ allocation changes have increased travel and subsequent cold ischemia times (CIT) of kidney allografts. We sought to investigate the impact of prolonged…
  • 2022 American Transplant Congress

    Prevalence of Mycophenolate Mofetil (MMF) Discontinuation and Outcomes in Pediatric Kidney Transplants (PKTX): A PNRC Study

    A. Moudgil1, K. Sgambat1, E. Benoit2, A. Jain3, M. Seifert4, C. Katsoufis5, L. Harshman6, A. Mansuri7, M. Somers8

    1Nephrology, Children's National Med. Ctr., Washington, DC, 2Nephrology, Boston's Children's Hospital, Boston, MA, 3Nephrology, Wayne State University, Troy, DC, 4Nephrology, The University of Alabama, Birmingham, AL, 5Nephrology, Holtz Children's Hospital, Miami, FL, 6Nephrology, University of Iowa, Iowa City, IA, 7Nephrology, Children's Hospital of Georgia, Augusta, GA, 8Nephrology, Boston Children's Hospital, Boston, MA

    *Purpose: MMF is discontinued in PKTX for various reasons. In this Pediatric Nephrology Research Consortium (PNRC) study, we determined prevalence and reasons for MMF discontinuation…
  • 2022 American Transplant Congress

    Utility of Urinary CTGF as a Biomarker of Progressive Allograft Dysfunction in Pediatric Renal Transplant Recipients

    L. Sheward1, J. Wedel1, N. Rodig1, A. Kho1, T. Blydt-Hansen2, R. B. Mannon3, D. M. Briscoe1

    1Boston Children's Hospital, Boston, MA, 2BC Children's Hospital, Vancouver, BC, Canada, 3University of Nebraska Medical Center, Omaha, NE

    *Purpose: Previous reports from a number of studies indicate that renal allograft recipients who have inflammatory infiltrates within areas of interstitial fibrosis with tubular atrophy…
  • 2022 American Transplant Congress

    Ultrasound Assessing Donor Kidney Quality in Deceased Donor Kidney Transplantation

    S. Yun1, K. Lee1, S. Park2, J. Park1

    1Surgery, Samsung Medical Center, Seoul, Korea, Republic of, 2Radiology and Center for Imaging Science, Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: We evaluated the role of functional kidney volume using donor kidney ultrasound (US) alone or in combination with other donor factors and parameters appropriate…
  • 2022 American Transplant Congress

    The Role of Advanced Practice Providers in Liver Transplant Centers

    S. Nargiso, L. Sher, V. Tristan

    Keck Medical Center at University of Southern California, Los Angeles, CA

    *Purpose: Care for the liver transplant (LT) recipient requires expertise and consistency. Due to the rotation of trainees and the emphasis on surgical experience for…
  • 2022 American Transplant Congress

    A Successful Expansion of Donor Liver Supply is Feasible with the Selective Use of Older DCD Livers

    M. Finotti, M. Rosenzweig, A. Wall, S. H. Lee, A. Gupta, J. Bayer, H. Fernandez, N. Onaca, R. Ruiz, G. Testa, G. J. McKenna

    Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX

    *Purpose: DCD are a key way to expand the donor pool, yet many centers are hesitant about using anything but the most favorable DCD allografts,…
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