Abstracts Archive - Page 50 of 1683 - ATC Abstracts

2022 American Transplant Congress
An Immune-Modulatory Strategy to Mitigate Hepatic Ischemia Reperfusion Injury in a Murine Model
S. Duarte, A. Kobayashi, V. Boominathan, A. Kwiatkowski, J. Simonovich, A. Wanchoo, G. Hudalla, B. Keselowsky, A. Zarrinpar
University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is the leading cause of early graft dysfunction and contributes to the shortage of donor liver grafts. However, despite its…
2022 American Transplant Congress
Prevalence of Mycophenolate Mofetil (MMF) Discontinuation and Outcomes in Pediatric Kidney Transplants (PKTX): A PNRC Study
A. Moudgil¹, K. Sgambat¹, E. Benoit², A. Jain³, M. Seifert⁴, C. Katsoufis⁵, L. Harshman⁶, A. Mansuri⁷, M. Somers⁸
¹Nephrology, Children's National Med. Ctr., Washington, DC, ²Nephrology, Boston's Children's Hospital, Boston, MA, ³Nephrology, Wayne State University, Troy, DC, ⁴Nephrology, The University of Alabama, Birmingham, AL, ⁵Nephrology, Holtz Children's Hospital, Miami, FL, ⁶Nephrology, University of Iowa, Iowa City, IA, ⁷Nephrology, Children's Hospital of Georgia, Augusta, GA, ⁸Nephrology, Boston Children's Hospital, Boston, MA
*Purpose: MMF is discontinued in PKTX for various reasons. In this Pediatric Nephrology Research Consortium (PNRC) study, we determined prevalence and reasons for MMF discontinuation…
2022 American Transplant Congress
A Dose Dependent Effect of Varying Tacrolimus Concentrations on Cytomegalovirus Viral Specific T Cell Interferon Gamma Expression
H. L. Kleiboeker¹, M. R. Jorgenson¹, R. O. Meyers², O. Ganz², S. Parajuli³, J. Galipeau⁴
¹Pharmacy, University of Wisconsin Hospital and Clinics, Madison, WI, ²Program for Advanced Cell Therapy, University of Wisconsin Hospital and Clinics and School of Medicine and Public Health, Madison, WI, ³Medicine, Division of Nephrology, University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁴Medicine, Division of Hematology and Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI
*Purpose: Tacrolimus, considered the backbone of transplant immunosuppression, is associated with increased risk of viral infections, including cytomegalovirus (CMV), due to its potent inhibitory effect…
2022 American Transplant Congress
Single-Cell CyTOF Profiling of Pediatric Immune Responses to Organ Transplantation Reveals a Novel Subpopulation of T Cells Significantly Correlating with Graft Health
M. Rao¹, M. Amouzgar¹, J. T. Harden¹, M. Lapasaran¹, A. Trickey¹, B. Armstrong², J. Odim³, T. Debnam³, C. Esquivel¹, S. C. Bendall¹, O. Martinez¹, S. M. Krams¹
¹Stanford University, Palo Alto, CA, ²Rho, Durham, NC, ³National Institutes of Health, Bethesda, MD
*Purpose: Solid organ transplant is lifesaving for children with end-stage heart, liver, or kidney disease. Protection of the transplanted organ from rejection requires long-standing immunosuppression.…
2022 American Transplant Congress
Hard to Place Dual Kidney Transplantation (HTPDKT): A Viable Option Despite Prolonged Cold Ischemia
R. Plews¹, E. Siskind², M. Laftavi², E. Shipman³, S. Shah², D. Conti⁴, A. Adekile², S. Nijim², S. K. Patel²
¹Albany Medical College, Albany, NY, ²Center for Transplantation, University Medical Center of Southern Nevada, Las Vegas, NV, ³Nevada Donor Network, Las Vegas, NV, ⁴Albany Medical Center, Albany, NY
*Purpose: Less than perfect kidneys are often difficult to place in the current kidney allocation system. The kidneys have to travel extended distances , increasing…
2022 American Transplant Congress
Left Ventricular Diastolic Dysfunction: Prevalence and Relation to Outcomes in Liver Transplantation Recipients
M. B. Hammami¹, H. Allaham², J. Grossman², P. Xue², K. Eagan², S. Gottlieb², C. Hong², L. Wang², C. Bhati², D. Maluf², K. Shetty², N. Urrunaga²
¹University of Maryland, Baltimore, MD, ²University of Maryland School of Medicine, Baltimore, MD
*Purpose: Assess the prevalence and characteristics of patients with pre-transplant left ventricular diastolic dysfunction (LVDD) and its potential impact on post-transplant morbidity and mortality.*Methods: Retrospective…
2022 American Transplant Congress
Single Center Retrospective Study Examining the Safety of the New Potassium- Binders for Post-Operative Hyperkalemia in Kidney Transplant Recipients
S. Kapoor¹, A. Campbell², Y. Azzi¹, L. E. Liriano-Ward³, T. Shertel⁴, W. Xiao⁵, D. U. Nnani⁶, S. Farghaly¹, S. Yun⁷, E. Akalin¹, M. Ajaimy¹
¹Einstein-Montefiore Transplant Center, Bronx, NY, ²Montefiore Medical Center, Bronx, NY, ³Transplant, Montefiore Medical Center, Bronx, NY, ⁴-, -, AL, ⁵Albert Einstein College of Medicine, Folsom, CA, ⁶Pharmacy, Montefiore Medical Center, Bronx, NY, ⁷Montefiore Medical Center, New York, NY
*Purpose: We aimed to evaluate the safety and efficacy of two potassium-binders (Patiromer and Sodium Zirconium Cyclosilicate (SZC) in early post-transplant hyperkalemia treatment of kidney…
2022 American Transplant Congress
HDAC6 Inhibition Mediated Protection from Hepatic Ischemia Reperfusion is Associated with Preserved Glutathione Levels
C. OBrien¹, P. Hernandez¹, S. Concors², Z. Wang¹, G. Ge³, A. Kozikowski⁴, W. Hancock⁵, M. Levine²
¹Surgery, University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Surgery, University of Pensylvania, Philadelphia, PA, ⁴College of Pharmacy, University of Illinois at Chicago, Chicago, IL, ⁵Childrens Hospital of Philadelphia, Philadelphia, PA
*Purpose: Liver Ischemia reperfusion injury (IRI) and Acetaminophen (APAP) toxicity are important causes of acute liver failure in the United States, that lack effective therapy.…
2022 American Transplant Congress
The Role of Advanced Practice Providers in Liver Transplant Centers
S. Nargiso, L. Sher, V. Tristan
Keck Medical Center at University of Southern California, Los Angeles, CA
*Purpose: Care for the liver transplant (LT) recipient requires expertise and consistency. Due to the rotation of trainees and the emphasis on surgical experience for…
2022 American Transplant Congress
Allo-Sensitization is Increased in Liver Transplant Recipients Following Ischemia-Reperfusion Injury
R. A. Sosa, A. Q. Terry, Y. Yin, B. V. Naini, F. M. Kaldas, R. W. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. F. Reed
UCLA, Los Angeles, CA
*Purpose: Recipient sensitization to donor HLA antigens remains an important clinical problem in transplantation, leading to increased wait times to find a compatible donor and…