Abstracts Archive - Page 481 of 1683 - ATC Abstracts

2020 American Transplant Congress
Tetramethylpyrazine Activated Pparγ in Resuscitating the Liver Graft Donatedafter Cardiac Death
F. Zhen, F. Lin, Z. Lihua, L. Wenjin, X. Yan, C. Yong, Y. Qifa
Zhongnan Hospital of Wuhan University, Wuhan, China
*Purpose: to identify whether Tetramethylpyrazine (TMP) pretreatment can protect DCD grafts preserved during cold storage or/and HMP and transplanted.The protective mechanisms of TMP were also…
2020 American Transplant Congress
Withaferin A Prolongs Islet Allograft Survival in a Mouse Transplant Model by Preventing T Lymphocyte Proliferation and Dendritic Cell Maturation
K. Kumano¹, M. A. Kanak², S. Vasu¹, Y. Liu¹, M. Lawrence¹, B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Virginial Commonwealth University Medical Center, Richmond, VA
*Purpose: Chronic decline in islet graft function and toxicities imposed by immunosuppressant drugs remain as challenges to the widespread use of islet transplantation for type…
2020 American Transplant Congress
XIAP Enhances Xenoislet Survival: Novel Models to Evaluate Pretransplantation Gene Modifications
G. R. Devi¹, Z. Fitch¹, M. Song¹, M. Ribeiro¹, A. McGowan¹, X. Luo², B. H. Collins¹, A. D. Kirk¹
¹Department of Surgery, Duke Univesity School of Medicine, Durham, NC, ²Division of Nephrology, Duke Univesity School of Medicine, Durham, NC
*Purpose: Porcine islet xenotransplantation offers a reliable and near limitless supply of islets for the treatment of type 1 diabetes. Intraportal infusion of cells exposes…
2020 American Transplant Congress
Lacripep^TM and its Analogs Act as Novel Interventional Agents to Promote Long-Term Islet Transplantation Outcomes
M. Ma¹, K. Teixeira², G. Laurie², K. Brayman¹, P. Chhabra¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Cell Biology, University of Virginia Health System, Charlottesville, VA
*Purpose: To study the prosecretory, prosurvival, and mitogenic effect of Lacripep™ and its analogs in enhancing islet viability, increasing insulin secretion and promoting long-term islet…
2020 American Transplant Congress
Human Antigen R (HuR): A New Regulator of Heme Oxygenase-1 Cytoprotection in Mouse and Human Liver Transplantation
K. J. Dery¹, K. Nakamura², K. Kadono¹, H. Hirao¹, S. Kageyama¹, T. Ito¹, H. Kojima¹, F. Kaldas¹, R. W. Busuttil¹, J. W. Kupiec-Weglinski¹
¹Department of Surgery, Division of Liver and Pancreas Transplantation, UCLA, Los Angeles, CA, ²Surgery, Nishi-Kobe Medical Center, Hyogo, Japan
*Purpose: Ischemia-reperfusion injury (IRI) represents a risk factor in liver transplantation (LT). We have shown that overexpression of heme oxygenase 1 (HO-1) mitigates hepatic IRI…
2020 American Transplant Congress
Inhibiting NLRP3 Inflammasome Ameliorates Glucose Fluctuation Through Reducing Apoptosis and Infiltration of Inflammatory Cells after Intraportal Islet Transplantation in Rodent Model
G. Yoshimatsu, T. Matsuoka, K. Chinen, N. Sakata, S. Kodama
Department of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
*Purpose: Islet transplantation is a useful treatment option for insulin dependent diabetes mellitus with severe hypoglycemic event. However, intraportal islet transplantation is known to induce…
2020 American Transplant Congress
Mesenchymal Stromal Cell Treatment of Kidneys During Normothermic Machine Perfusion is Safe and Feasible with Effective Traceability after Transplantation
K. Rozenberg¹, S. Lohmann², M. Pool³, M. Eijken⁴, U. Møldrup⁵, B. Møller⁶, J. Sierra-Parraga⁷, M. Hoogduijn⁷, L. Lo Faro¹, C. Moers³, J. Hunter¹, A. Keller², H. Leuvenink³, C. Baan⁷, R. Ploeg¹, B. Jespersen²
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ³Department of Surgery, University Medical Center Groningen, Groningen, Netherlands, ⁴Department of Renal Medicine, Aarhus University, Aarhus, Denmark, ⁵Department of Urology, Aarhus University, Aarhus, Denmark, ⁶Department of Clinical Immunology, Aarhus University, Aarhus, Denmark, ⁷Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands
*Purpose: Marginal kidneys are increasingly being accepted to decrease waiting time for a transplant. Normothermic machine perfusion (NMP) is a technique that allows delivery of…
2020 American Transplant Congress
Bone Marrow Mesenchymal Stem Cells Improve Rat Islet Angiogenesis by Upregulating of ISL1 and VEGF-A
Y. Wang¹, J. Wang², X. Ding²
¹Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China, ²Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
*Purpose: Islet transplantation is an important therapy to cure diabetes, but poor angiogenesis in the early stage of islet transplantation is one of the main…
2020 American Transplant Congress
AIPCs Home to and Engraft in the Pancreas When Injected Intravenously
J. B. Pollett¹, N. Thai²
¹Imagine Pharma, Pittsburgh, PA, ²Allegheny Health Network, Pittsburgh, PA
*Purpose: AIPCs (Activated Islet Proliferating Cells) are a recently developed cell population generated from isolated islets of mice and humans. AIPCs are over 65% CD133-,…
2020 American Transplant Congress
Anti-CD321 Antibody (90G4) Protects Liver against Ischemia Reperfusion Injury in a Murine Model
E. Yin¹, T. Fukuhara², H. Bashuda¹, K. Uchida³
¹Atopy Research Center, Juntendo University School of Medicine, Tokyo, Japan, ²Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan, ³Juntendo Advanced Research Institute for Health Science, Juntendo University School of Medicine, Tokyo, Japan
*Purpose: Ischemia reperfusion results in increased transmigration of leukocytes into tissue. This eventually leads to post transplant graft damage after organ transplantation. CD321 (also known…