Abstracts Archive - Page 478 of 1683 - ATC Abstracts

2020 American Transplant Congress
Activation of the ICOS/ICOS-Ligand Pathway in Antibody-Mediated Kidney Graft Rejection
V. Cantaluppi¹, G. Merlotti¹, M. Quaglia¹, G. Rosso¹, N. Clemente¹, G. Cappellano¹, A. Chiocchetti¹, G. Castellano², U. Dianzani¹, G. Camussi³
¹Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy, ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Foggia, Foggia, Italy, ³Department of Medical Sciences, University of Torino, Torino, Italy
*Purpose: The costimulatory pathway ICOS/ICOS-Ligand may represent a new therapeutic target in antibody-mediated rejection (ABMR), the major cause of long term kidney graft failure. The…
2020 American Transplant Congress
Impact of Body Mass Index on Methodsof Assessing Glomerular Filtration Rate in Living Kidney Donors
Y. Lu¹, A. Naik¹, R. Doshi², K. Woodside³, M. Doshi¹
¹Internal Medicine, University of Michigan, Ann Arbor, MI, ²Internal Medicine, Vanderbilt University, Nashville, TN, ³Surgery, University of Michigan, Ann Arbor, MI
*Purpose: The current Organ Procurement and Transplantation Network (OPTN) policy on living kidney donors (LKD) require that all LKD candidates have measured glomerular filtration rate…
2020 American Transplant Congress
Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) in Renal Allograft Biopsies (Bx) Are Beneficial to Clarifying ABMR Activity in Ambivalent Cases
H. Zhang¹, C. C. Nast², N. Ammerman³, A. A. Vo³, I. Gallegos³, M. Arevalo³, S. C. Jordan³, M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: “Thoroughly validated gene transcripts” in renal Bx was adopted as one of the criteria for ABMR diagnosis in the latest Banff classification. Here, we…
2020 American Transplant Congress
High-Activity Classical and Alternative Complement Pathway Genotypes – Association with Donor-Specific Antibody-Triggered Injury and Renal Allograft Survival
R. Reindl-Schwaighofer¹, B. Mezö², F. Eskandary¹, A. Heinzel¹, M. Wahrmann¹, K. Doberer¹, A. Heilos³, G. Bond¹, J. Kläger⁴, N. Kozakowski⁴, H. Haslacher⁵, R. Oberbauer¹, O. Viklický⁶, P. Hruba⁶, P. F. Halloran⁷, K. Rusai³, Z. Prohászka⁸, G. A. Böhmig¹
¹Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary, ³Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria, ⁴Department of Pathology, Medical University of Vienna, Vienna, Austria, ⁵Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria, ⁶Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁷Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada, ⁸Department of Medicine III, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary
*Purpose: Complement may contribute to donor-specific antibody (DSA)-triggered transplant injury. Here, we investigated whether the intrinsic strength of classical (CP) and alternative complement pathways (AP)…
2020 American Transplant Congress
Impact of Belatacept Conversion on Renal Function, Histology and Gene Expression in Kidney Transplant Patients with Chronic Active Antibody-Mediated Rejection
D. Kumar¹, I. Yakubu¹, S. Paluri¹, A. Chachar¹, J. Chang², I. Moinuddin¹, L. Kamal¹, M. Levy¹, C. Bhati¹, A. King¹, P. Kimball¹, P. Halloran², G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²ATAGC, Edmonton, AB, Canada
*Purpose: Chronic active antibody mediated rejection (cABMR) is a major cause kidney transplant (KT) loss. Current therapies have unclear efficacy and side effects. Basic and…
2020 American Transplant Congress
Physician Survey on Using APOL1 Genetic Testing in Live Kidney Donor Selection
M. Doshi¹, E. Gordon², B. Freedman³, C. Thomas⁴, C. Glover⁵, J. Locke⁶
¹Medicine, University of Michigan, Ann Arbor, MI, ²Surgery, Northwestern University, Chicago, IL, ³Medicine, Wake Forest, Winston-Salem, NC, ⁴Medicine, University of Iowa, Iowa City, IA, ⁵N/A, Miami, FL, ⁶Surgery, University of Alabama, Birmingham, AL
*Purpose: Live kidney donors of recent African ancestry are at an increased risk of developing end stage kidney disease than matched healthy non-donors. A recent…
2020 American Transplant Congress
Proposed New Kidney Allocation Policy: Moving to Concentric Circles as the First Unit of Allocation
A. Israni¹, S. Gustafson¹, A. Wey¹, B. Thompson¹, V. Casingal², M. Pavlakis³, S. Castro⁴, A. Wilk⁴, B. Kasiske¹, J. Snyder¹
¹SRTR, Minneapolis, MN, ²Carolinas Healthcare, Charlotte, NC, ³Beth Israel Deaconess, Boston, MA, ⁴UNOS, Richmond, VA
*Purpose: The Organ Procurement and Transplantation Network (OPTN) proposed a new national deceased donor kidney allocation policy that removes donor service area and OPTN region…
2020 American Transplant Congress
A Stroke Volume-Based Fluid Resuscitation Protocol Decreases Vasopressor Support and Increases Organ Yield in Brain-Dead Donors
G. F. Marklin
Mid-America Transplant, St Louis, MO
*Purpose: Brain-dead donors are frequently hypovolemic and hypotensive requiring vasopressor support. The goal of fluid resuscitation is to increase perfusion and oxygen delivery and avoid…
2020 American Transplant Congress
Artificial Intelligence May Detect Donor Liver Steatosis and Predict Early Post-Transplantation Graft Failure
R. R. Narayan, L. Yang, N. Abadilla, S. B. Chen, J. P. Higgins, M. L. Melcher
Stanford University, Stanford, CA
*Purpose: To compare the accuracy of donor liver biopsy slides scored by manual histopathologic review versus a computer vision artificial intelligence (CVAI) platform to predict…
2020 American Transplant Congress
Characteristics of Anonymous Living Donors and Their Recipients. Appropriate Use of a Rare and Valuable Gift
A. Sharfuddin, M. Panezai, M. Yaqub, D. Mishler, O. Adebiyi, T. Taber
Indiana University School of Medicine, Indianapolis, IN
*Purpose: Anonymous Living Donors are a special select set of donors. As there continues to be advances in Paired Donation, we review the trends and…