Abstracts Archive - Page 476 of 1683 - ATC Abstracts

2020 American Transplant Congress
Prospective Donor-Specific CellUlar Alloresponse Assessment for Immunosuppression MinImization in De Novo Renal Transplantation: Results of a Randomized Controlled Biomarker-Guided Trial
O. Bestard¹, P. Reinke², F. Bemelman³, O. Viklicky⁴, M. Koch⁵, M. Giral⁶, J. Ruiz⁷, B. Banas⁸, E. Crespo¹, M. Meneghini¹, H. Volk⁹, J. Grinyo¹
¹Kidney transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, ²Kidney transplantation Unit, Charité - Universitätsmedizin Berlin, Berlin, Germany, ³Kidney transplantation Unit, Amsterdam Medical Centre, Amsterdam, Netherlands, ⁴Nephrology department, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic, ⁵Department of Hepatobiliary Surgery and Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁶Nephrology, Kidney transplantation Unit, Université de Nantes, Nantes, France, ⁷Nephrology, Hospital Marques de Valdecilla, Santander, Spain, ⁸Kidney transplantation Unit, University Hospital Regensburg, Regensburg, Germany, ⁹Institute for Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany
*Purpose: Early immunosuppression minimization is associated with higher rates of BPAR. Preformed donor-specific T-cell alloreactivity (DST) assessed with an IFN-γ ELISPOT assay has shown to…
2020 American Transplant Congress
Identification of Molecular Markers for Liver Cirrhosis (NASH) by Single-Nucleus RNA Sequencing
C. Kuscu¹, A. Mouhammed², C. Kuscu³, A. R. Wolen³, J. D. Eason³, D. Maluf³, V. Mas³
¹Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN, ²Bioinformatics, University of Tennessee Health Science Center, Memphis, TN, ³Department of Surgery, University of Tennessee Health Science Center, Memphis, TN
*Purpose: Non-alcoholic fatty liver disease (NAFLD) is a progressive disease and it constitutes a significant portion of the chronic liver diseases that affected more than…
2020 American Transplant Congress
Trough Level Compliance in Immunosuppression is Important to Protect Renal Function after Liver Transplantation – An Additional Analysis from the Hephaistos Study
P. Schemmer¹, F. Braun¹, H. J. Schlitt¹, A. Pascher¹, C. G. Klein¹, U. Neumann¹, I. Kroeger², P. Wimmer², B. Nashan¹
¹Hephaistos, Study Group, Germany, ²Novartis Pharma GmbH, Nürnberg, Germany
*Purpose: Most immunosuppressive drugs are dosed according to trough levels (C0-levels). To achieve the optimal balance between efficacy and safety, it is important to avoid…
2020 American Transplant Congress
Steroid Withdrawal and Lymphocyte Subsets in Graft Capillary Blood versus Peripheral Blood in Low Immunological Risk Kidney Transplant Patients: Randomized, Parallel Group, Controlled Clinical Trial
T. Vazquez Sanchez, A. Caballero, J. Alonso-Titos, V. Lopez, E. Sola, M. Cabello, E. Gutierrez Vilchez, M. Martínez-Esteban, P. Ruiz Esteban, J. Delgado, D. Hernandez
Regional University Hospital, Malaga, Spain
*Purpose: Whether steroid withdrawal can modulate the subclinical inflammatory response after a kidney transplant is unknown.*Methods: We undertook a controlled multicenter clinical trial involving 105…
2020 American Transplant Congress
Stability of T Reg with Combination of mTOR Inhibitors with Belatacept in Reducing Risk of Acute Rejection in Kidney Transplant
J. Shoji, J. Leung, Q. Tang, F. Vincenti
University of California San Francisco (UCSF), San Francisco, CA
*Purpose: Belatacept is a costimulatory blocker that is used as de novo maintenance immunosuppression in kidney transplantation to avoid toxic effects of calcineurin inhibitors and…
2020 American Transplant Congress
Single Cell RNA Transcriptomics to Further the Precision Transplantation Medicine Approaches in Kidney Allograft Recipients
H. Suryawanshi, H. Yang, M. Lubetzky, S. Seshan, T. Tuschl, M. Suthanthiran, T. Muthukumar
Weill Cornell Medicine, New York, NY
*Purpose: Test the hypothesis that single cell RNA transcriptomics will further the precision transplantation medicine approaches and address important conundrums in clinical transplantation.*Methods: We studied…
2020 American Transplant Congress
Autophagy-Lysosome Inhibitor Chloroquine Prevents CTLA-4 Degradation of T Cells and Attenuates Acute Rejection in Murine Skin and Heart Transplantation
J. Wu
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: The immune checkpoint cytotoxic T lymphocyte antigen-4 (CTLA-4), which was induced upon T cell activation but degraded quickly, has been targeted in the clinical…
2020 American Transplant Congress
Frailty is Strongly Associated with Self-Reported Symptom Burden among Patients with Cirrhosis Undergoing Evaluation for Liver Transplantation
L. X. Deng, K. E. Bischoff, D. S. Kent, D. L. O’Riordan, S. Z. Pantilat, J. C. Lai
University of California, San Francisco, San Francisco, CA
*Purpose: Among patients with cirrhosis, frailty has most commonly been measured using instruments that focus on malnutrition, muscle wasting, and functional impairment. Little is known…
2020 American Transplant Congress
Introducing the Smartphone App, EL-FIT (Exercise & Liver FITness), to Help Monitor and Prehabilitate Liver Transplant Candidates
A. Duarte-Rojo¹, P. M. Bloomer¹, R. J. Rogers², M. A. Dunn¹, E. B. Tapper³, R. Bataller¹, C. B. Hughes¹, A. A. Ferrando¹, W. R. Kim⁴, J. M. Jakicic²
¹University of Pittsburgh Medical Center, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³University of Michigan, Ann Arbor, MI, ⁴Stanford University, Palo Alto, CA
*Purpose: Physical activity is key to liver transplant (LT) prehabilitation, and leveraging technologies to monitor physical performance and to generalize training may be advantageous. EL-FIT…
2020 American Transplant Congress
Gene Expression Dynamics Demonstrate Perturbations in Innate and Adaptive Immunity in Kidney Transplantation Patients with Cytomegalovirus Viremia
R. Ahn, J. Schaenman, Z. Qian, V. Groysberg, M. Rossetti, A. Hoffmann, D. Gjertson, M. Deng, E. F. Reed
University of California Los Angeles, Los Angeles, CA
*Purpose: Cytomegalovirus (CMV) viremia and disease continues to cause significant morbidity and mortality in kidney transplant patients with clinical complications including organ rejection and death.…