ATC Abstracts

American Transplant Congress abstracts

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  • 2020 American Transplant Congress

    Tissue Resident Memory T Cells in Mouse Renal Transplantation

    K. Abou-Daya1, D. Zhao1, R. Tieu1, R. Rammal2, M. Oberbarnscheidt1, F. Lakkis1

    1Starzl Transplantation Institute, Pittsburgh, PA, 2American University of Beirut, Beirut, Lebanon

    *Purpose: The newly identified tissue resident subset of memory T cells (TRM) provides immune surveillance in the tissue and first response against infections. They are…
  • 2020 American Transplant Congress

    Improved Medication Safety Outcomes with a Mobile Health, Pharmacist-Led Intervention: Results of the TRANSAFE Rx Randomized Controlled Trial

    H. Gonzales, J. Fleming, M. Gebregziabher, J. McGillicuddy, D. Taber

    MUSC, Charleston, SC

    *Purpose: Medication (med) safety events are a predominant cause of poor health outcomes, particularly within high-risk groups such as kidney transplant (KTX) recipients. The primary…
  • 2020 American Transplant Congress

    Memory T Cell-Mediated Rejection is Regulated by FcγRIIB Expression on CD8+ T Cells

    A. B. Morris, D. F. Pinelli, D. Liu, M. L. Ford

    Emory University, Atlanta, GA

    *Purpose: Donor-reactive memory T cells represent a potent immunologic barrier to long-term graft survival and tolerance induction. To identify novel pathways that regulate memory T…
  • 2020 American Transplant Congress

    Frailty Attenuates the Gender Gap in Waitlist Mortality in Liver Transplant Candidates: A Multi-Center Study with 1,240 Patients with Cirrhosis

    J. C. Lai1, D. R. Ganger2, M. L. Volk3, J. L. Dodge1, M. A. Dunn4, A. Duarte-Rojo5, M. R. Kappus6, R. S. Rahimi7, D. Ladner2, B. Boyarsky8, M. McAdams-DeMarco8, D. L. Segev8, C. E. McCulloch1, E. Verna9

    1UCSF, San Francisco, CA, 2NW, Chicago, IL, 3Loma Linda Univ, Loma Linda, CA, 4UPMC, Pittsburgh, CA, 5UPMC, Pittsburgh, PA, 6Duke, Durham, NC, 7Baylor, Dallas, TX, 8JHMI, Baltimore, MD, 9Columbia, New York, NY

    *Purpose: Women LT candidates experience higher rates of waitlist mortality than men. Frailty is a critical determinant of mortality in patients with cirrhosis but it…
  • 2020 American Transplant Congress

    Treg Protection of the Allograft Depends on Lymphotoxin Beta Receptor Expression in Lymphatic Endothelial Cells

    V. Saxena1, W. Piao1, L. Li1, Y. Xiong1, C. Palusckievicz1, T. Simon1, M. Shirkey1, R. Abdi2, J. S. Bromberg1

    1University of Maryland, Baltimore, Baltimore, MD, 2Harvard U, Boston, MA

    *Purpose: Regulatory T cell (Treg) migration to afferent lymphatics and lymph nodes (LN), and suppressive function, require Treg lymphotoxin alpha (LTα) to stimulate LT beta-receptor…
  • 2020 American Transplant Congress

    Single Cell RNA Sequencing of Normal Kidney Allograft Surveillance Biopsies Show Evidence of Dynamic Glomerular Endothelial Cell Activation

    A. S. Naik, R. Menon, E. Otto, C. C. Berthier, E. Farkash, S. P. Norman, M. Kretzler

    University of Michigan, Ann Arbor, MI

    *Purpose: Indication and surveillance biopsy studies show a high prevalence of post kidney transplant (KT) glomerular disease (ElZoghby 2009,Stegall 2017) that cannot be explained by…
  • 2020 American Transplant Congress

    Additive Effect of Obesity to Hypertension in Living Donors and Their Impact on Glomerular Filtration Rate Compensation with 5 Year Follow-Up

    S. Quadri1, H. Ali2, T. Fulop1, A. Osman3, K. Soliman1

    1Nephrology, Medical University of South Carolina, Charleston, SC, 2Renal Medicine, Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom, 3Nephrology, Cairo University, Cairo, Egypt

    *Purpose: Current data suggest that hypertensive donors can be considered for donation; however, the additive adverse effect of obesity and the risk of failing Glomerular…
  • 2020 American Transplant Congress

    Allograft Repopulating Recipient B Cells after Human Intestinal Transplantation and Their Association with Donor Specific Antibody Secretion and Rejection

    E. Waffarn1, J. Fu1, K. Frangaj1, W. Meng2, A. M. Rosenfeld2, M. Li3, K. Rodgers1, R. Vasilescu3, E. T. Luning Prak2, A. Griesemer1, T. Kato4, M. Martinez5, M. Sykes1

    1Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 3Department of Pathology, Columbia University, New York, NY, 4Department of Surgery, Columbia University, New York, NY, 5Department of Pediatrics, Columbia University, New York, NY

    *Purpose: Alloantibodies produced by recipient B cells are associated with rejection after intestinal transplantation (ITx) and negatively impact patient and graft survival. However, the dynamics…
  • 2020 American Transplant Congress

    Hemodialysis (HD) Treatment Associates with Increased Risk of Delayed Graft Function (DGF) after Renal Transplantation (RT) and Augmented Cd4 and Cd8 T Cell Proliferation Compared to Peritoneal Dialysis (PD)

    A. Angeletti1, C. Donadei1, G. Donati1, G. Di Certo1, D. Conte1, L. Gasperoni1, E. Pelizzaro1, C. Guglielmo1, G. Comai1, P. Cravedi2, G. La Manna1

    1DIMES, S.Orsola-Malpighi Hospital, Bologna University, Bologna, Italy, 2DIMES, Icahn School of Medicine at Mount Sinai, New York, NY, US, New York, NY

    *Purpose: Delayed graft function (DGF) is a common event after RT that increases the risk of acute rejection and early graft loss. The impact of…
  • 2020 American Transplant Congress

    To Wait or Not to Wait: The Survival Benefit of Preemptive Kidney Transplantation after Accounting for Lead Time Bias

    S. Yu1, A. Kernodle1, J. Snyder2, J. Garonzik-Wang1, D. Segev1, A. Massie1

    1Johns Hopkins, Baltimore, MD, 2SRTR, Minneapolis, MN

    *Purpose: Over 2,000 preemptive living donor kidney transplants (LDKT) per year are performed in the US. Preemptive LDKT allows recipients to avoid dialysis, but increases…
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