Abstracts Archive - Page 473 of 1683 - ATC Abstracts

2020 American Transplant Congress
Changes in Health-Related Quality of Life During the First Year in Lung Transplantation Recipients
H. Zhou, J. Chen
Lung Transplant Center, Wuxi People’s Hospital, Wuxi, China
*Purpose: This longitudinal study was conducted to recognize the tracks of HRQOL during the first year after transplantation and the main factors associated with HRQOL…
2020 American Transplant Congress
Outcome Implications of Prescription Opioid and Benzodiazepine in Lung Transplant Patients: Analysis of Linked Registry and Pharmacy Claims Data
K. Lentine¹, L. Myaskovsky², H. Bruschwein³, M. Dew⁴, Z. Zhang¹, M. McAdams Demarco⁵, D. Segev⁵, D. Axelrod⁶, G. Hess⁷, B. Kasiske⁸, J. Snyder⁸, M. Schnitzler⁹
¹Department of Medicine, Saint Louis University, Saint Louis, MO, ²Univ of New Mexico, Albuquerque, NM, ³Univ of Virginia, Charlottesville, VA, ⁴Univ of Pittsburgh, Pittsburgh, PA, ⁵Johns Hopkins, Baltimore, MD, ⁶Univ of Iowa, Iowa City, IA, ⁷Drexel University, Philadelphia, PA, ⁸SRTR, Minneapolis, MN, ⁹Saint Louis University, Saint Louis, MO
*Purpose: To investigate the frequency, correlates, and outcomes associated with prescription opioid and benzodiazepine use before and after lung transplant (LuTx).*Methods: We examined a linkage…
2020 American Transplant Congress
Kidney Alkalization Increases Macula Densa NOS1β Expression and Improves Transplanted Renal Graft Function
J. Buggs¹, J. Zhang², J. Wei², L. Wang²
¹Transplant Surgery, Tampa General Hospital, Tampa, FL, ²Molecular Pharmacology & Physiology, University of South Florida, Morsani College of Medicine, Tampa, FL
*Purpose: Ischemia-reperfusion injury (IRI) is a major survival hurdle with kidney transplantation (KTX). Currently, no effective strategies for the prevention and treatment of IRI during…
2020 American Transplant Congress
Gasdermin-D Mutation is Protective against Renal Ischemia Reperfusion Injury
J. Li, N. Rogers, S. Alexander
Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, Australia
*Purpose: Pyroptosis, a pro-inflammatory form of cell death, is dependent on membrane pore formation through the assembly of cleaved Gasdermin-D molecules. We hypothesized that this…
2020 American Transplant Congress
Identification of Novel Gene Targets Inducing Resistance in Liver Ischemia Reperfusion Injury by CRISPR Screening
C. Kuscu, A. R. Wolen, C. Kuscu, C. Watkins, A. Bajwa, J. D. Eason, D. Maluf, V. Mas
Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN
*Purpose: Liver transplantation (LT) is the best treatment option for patients with end-stage liver disease (ESLD). However, the gap between available donors and recipients in…
2020 American Transplant Congress
Sirolimus Plus Tacrolimus Immunosuppression, with or without Mycophenolate Mofetil, May Improve Survival after Bronchiolitis Obliterans Syndrome in Lung Transplant Patients
M. Wijesinha, M. Terrin, B. Griffith, A. Iacono
University of Maryland School of Medicine, Baltimore, MD
*Purpose: There are very few ways to improve survival after bronchiolitis obliterans syndrome (BOS), the leading cause of death in lung transplant patients. Two long-term…
2020 American Transplant Congress
Heart Transplant Outcomes in Patients Who Receive Hepatitis B Virus-Positive Donor Hearts: A UNOS Registry Analysis
P. Genyk¹, K. Yang², R. Chand³, E. Depasquale¹
¹Keck Medicine of USC, Los Angeles, CA, ²Keck Medicine of USC, South Pasadena, CA, ³Harbor-UCLA Medical Center, Los Angeles, CA
*Purpose: Hepatitis B infection in post-transplant patients posed a challenge in the setting of immunosuppression. However, the advent of anti-viral therapy for HBV has made…
2020 American Transplant Congress
UNOS Hard to Place Kidneys: Are We Working Too Hard?
S. Chaudhry, K. L. King, S. A. Husain, D. Cohen, L. Ratner, S. Mohan
Columbia University, New York, NY
*Purpose: Kidneys requiring more than 100 offers before acceptance are defined by UNOS as “hard to place," but many are suitable for transplantation. We sought…
2020 American Transplant Congress
A Single-Center Analysis of Using Allele-Level 11 HLA Loci Information on cPRA and Organ-Allocation Points in Kidney Transplant Candidates
C. Maguire¹, P. Muluhngwi¹, E. Kransdorf², L. Gragert³, A. R. Tambur¹
¹Northwestern University, Chicago, IL, ²Cedars-Sinai Heart Institute, Beverly Hills, CA, ³Tulane University, New Orleans, LA
*Purpose: Calculated panel reactive antibodies (cPRA) is used by the United Network for Organ Sharing (UNOS) to quantify degree of HLA sensitization and assign priority…
2020 American Transplant Congress
Survival after Lung Transplantation by Discharge Immunosuppressive Regimen: An Analysis of Organ Procurement and Transplantation Network Data
W. S. Cherikh¹, B. J. Plucinski¹, S. Palmer², W. E. Fitzsimmons³
¹United Network for Organ Sharing, Richmond, VA, ²Duke University Hospital, Durham, NC, ³Fitzsimmons LLC, Vernon Hills, IL
*Purpose: As the optimal immunosuppressive (IS) regimen after lung (LU) transplant (TX) is unknown, we conducted an analysis to compare the effect of four different…