2020 American Transplant Congress
Tissue Resident Memory T Cells in Mouse Renal Transplantation
1Starzl Transplantation Institute, Pittsburgh, PA, 2American University of Beirut, Beirut, Lebanon
*Purpose: The newly identified tissue resident subset of memory T cells (TRM) provides immune surveillance in the tissue and first response against infections. They are…2020 American Transplant Congress
Improved Medication Safety Outcomes with a Mobile Health, Pharmacist-Led Intervention: Results of the TRANSAFE Rx Randomized Controlled Trial
*Purpose: Medication (med) safety events are a predominant cause of poor health outcomes, particularly within high-risk groups such as kidney transplant (KTX) recipients. The primary…2020 American Transplant Congress
Memory T Cell-Mediated Rejection is Regulated by FcγRIIB Expression on CD8+ T Cells
*Purpose: Donor-reactive memory T cells represent a potent immunologic barrier to long-term graft survival and tolerance induction. To identify novel pathways that regulate memory T…2020 American Transplant Congress
Two-Year Post-Transplant eGFR as a Surrogate Outcome of Allograft Survival in Kidney Transplant Recipients
*Purpose: Graft failure is a major cause of morbidity and mortality in kidney transplant recipients. However, trials aimed to assess the effect of interventions on…2020 American Transplant Congress
Factors Influencing Background Cell-Free DNA Levels: Implications for Donor-Derived Cell-Free DNA Assessment in Transplant Patients
*Purpose: Detecting elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the plasma of transplant recipients has been used as a metric to determine graft injury…2020 American Transplant Congress
Electroacupuncture Promotes Induction of Long-Term Allograft Survival by Enhancing Lymphatic Migration of CD4+Foxp3+ Tregs via Upregulating Their LTalpha1beta2 Expression
Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
*Purpose: Induction of long-term transplant survival without continuous global immunosuppression is a highly desired goal in transplantation. Electroacupuncture (EA) has been shown to regulate immunity…2020 American Transplant Congress
Treg Protection of the Allograft Depends on Lymphotoxin Beta Receptor Expression in Lymphatic Endothelial Cells
1University of Maryland, Baltimore, Baltimore, MD, 2Harvard U, Boston, MA
*Purpose: Regulatory T cell (Treg) migration to afferent lymphatics and lymph nodes (LN), and suppressive function, require Treg lymphotoxin alpha (LTα) to stimulate LT beta-receptor…2020 American Transplant Congress
Single Cell RNA Sequencing of Normal Kidney Allograft Surveillance Biopsies Show Evidence of Dynamic Glomerular Endothelial Cell Activation
University of Michigan, Ann Arbor, MI
*Purpose: Indication and surveillance biopsy studies show a high prevalence of post kidney transplant (KT) glomerular disease (ElZoghby 2009,Stegall 2017) that cannot be explained by…2020 American Transplant Congress
Frailty Attenuates the Gender Gap in Waitlist Mortality in Liver Transplant Candidates: A Multi-Center Study with 1,240 Patients with Cirrhosis
*Purpose: Women LT candidates experience higher rates of waitlist mortality than men. Frailty is a critical determinant of mortality in patients with cirrhosis but it…2020 American Transplant Congress
Additive Effect of Obesity to Hypertension in Living Donors and Their Impact on Glomerular Filtration Rate Compensation with 5 Year Follow-Up
*Purpose: Current data suggest that hypertensive donors can be considered for donation; however, the additive adverse effect of obesity and the risk of failing Glomerular…
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