2020 American Transplant Congress
Tissue Resident Memory T Cells in Mouse Renal Transplantation
1Starzl Transplantation Institute, Pittsburgh, PA, 2American University of Beirut, Beirut, Lebanon
*Purpose: The newly identified tissue resident subset of memory T cells (TRM) provides immune surveillance in the tissue and first response against infections. They are…2020 American Transplant Congress
p40 Homodimers Indirectly Induce Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts and CTLA-4ig Resistant Graft Rejection via IL-15 Signaling
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: We have reported that longer duration of cold ischemic storage (CIS) prior to transplant resulted in increased proliferation of endogenous donor-reactive CD8 T cells…2020 American Transplant Congress
Single Cell RNA Sequencing of Normal Kidney Allograft Surveillance Biopsies Show Evidence of Dynamic Glomerular Endothelial Cell Activation
University of Michigan, Ann Arbor, MI
*Purpose: Indication and surveillance biopsy studies show a high prevalence of post kidney transplant (KT) glomerular disease (ElZoghby 2009,Stegall 2017) that cannot be explained by…2020 American Transplant Congress
Frailty Attenuates the Gender Gap in Waitlist Mortality in Liver Transplant Candidates: A Multi-Center Study with 1,240 Patients with Cirrhosis
*Purpose: Women LT candidates experience higher rates of waitlist mortality than men. Frailty is a critical determinant of mortality in patients with cirrhosis but it…2020 American Transplant Congress
Treg Protection of the Allograft Depends on Lymphotoxin Beta Receptor Expression in Lymphatic Endothelial Cells
1University of Maryland, Baltimore, Baltimore, MD, 2Harvard U, Boston, MA
*Purpose: Regulatory T cell (Treg) migration to afferent lymphatics and lymph nodes (LN), and suppressive function, require Treg lymphotoxin alpha (LTα) to stimulate LT beta-receptor…2020 American Transplant Congress
Additive Effect of Obesity to Hypertension in Living Donors and Their Impact on Glomerular Filtration Rate Compensation with 5 Year Follow-Up
*Purpose: Current data suggest that hypertensive donors can be considered for donation; however, the additive adverse effect of obesity and the risk of failing Glomerular…2020 American Transplant Congress
Improved Medication Safety Outcomes with a Mobile Health, Pharmacist-Led Intervention: Results of the TRANSAFE Rx Randomized Controlled Trial
*Purpose: Medication (med) safety events are a predominant cause of poor health outcomes, particularly within high-risk groups such as kidney transplant (KTX) recipients. The primary…2020 American Transplant Congress
Two-Year Post-Transplant eGFR as a Surrogate Outcome of Allograft Survival in Kidney Transplant Recipients
*Purpose: Graft failure is a major cause of morbidity and mortality in kidney transplant recipients. However, trials aimed to assess the effect of interventions on…2020 American Transplant Congress
Older Organs Transfer Senescence to Transplant Recipients
1Brigham and Women's Hospital, Boston, MA, 2Mayo Clinic, Rochester, MN
*Purpose: Older organs represent an underutilized potential. Organ age, at the same time, augments alloimmune responses resulting into increased acute rejection rates. Senescent cells accumulate…2020 American Transplant Congress
Cmv Infection Sensitizes Transplant Recipients by Promoting Alloreactive T Cell Response
Nephrology/Medicine, Duke University, Durham, NC
*Purpose: Cytomegalovirus (CMV) infection has been associated with allograft rejection in immunosuppressed transplant recipients. We have previously shown that acute CMV infection impairs the induction…
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