2020 American Transplant Congress
Memory T Cell-Mediated Rejection is Regulated by FcγRIIB Expression on CD8+ T Cells
*Purpose: Donor-reactive memory T cells represent a potent immunologic barrier to long-term graft survival and tolerance induction. To identify novel pathways that regulate memory T…2020 American Transplant Congress
Improving DRG Based Reimbursement to Reflect Complexity of Kidney Transplant
*Purpose: More than 90,000 individuals await a kidney transplant (KTx) in the US, yet up to 20% of recovered kidneys are discarded. Organ Transplant Centers…2020 American Transplant Congress
Treg Protection of the Allograft Depends on Lymphotoxin Beta Receptor Expression in Lymphatic Endothelial Cells
1University of Maryland, Baltimore, Baltimore, MD, 2Harvard U, Boston, MA
*Purpose: Regulatory T cell (Treg) migration to afferent lymphatics and lymph nodes (LN), and suppressive function, require Treg lymphotoxin alpha (LTα) to stimulate LT beta-receptor…2020 American Transplant Congress
Additive Effect of Obesity to Hypertension in Living Donors and Their Impact on Glomerular Filtration Rate Compensation with 5 Year Follow-Up
*Purpose: Current data suggest that hypertensive donors can be considered for donation; however, the additive adverse effect of obesity and the risk of failing Glomerular…2020 American Transplant Congress
Single Cell RNA Sequencing of Normal Kidney Allograft Surveillance Biopsies Show Evidence of Dynamic Glomerular Endothelial Cell Activation
University of Michigan, Ann Arbor, MI
*Purpose: Indication and surveillance biopsy studies show a high prevalence of post kidney transplant (KT) glomerular disease (ElZoghby 2009,Stegall 2017) that cannot be explained by…2020 American Transplant Congress
Allograft Repopulating Recipient B Cells after Human Intestinal Transplantation and Their Association with Donor Specific Antibody Secretion and Rejection
*Purpose: Alloantibodies produced by recipient B cells are associated with rejection after intestinal transplantation (ITx) and negatively impact patient and graft survival. However, the dynamics…2020 American Transplant Congress
Trends in Living Kidney Donation in the United States
Johns Hopkins University, Baltimore, MD
*Purpose: After peaking in 2014, the number of LKDTs per year dropped substantially in the US despite an increasing waitlist. However, trends in the KAS…2020 American Transplant Congress
Crosstalk between TLR4 and HLA Class I Mediates P-Selectin Expression and Monocyte Capture to Endothelial Cells
Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA
*Purpose: Transplant recipients developing donor specific HLA antibodies (DSA) are at risk for acute and chronic antibody-mediated rejection (AMR). DSA contribute to the process of…2020 American Transplant Congress
Flagging of Transplant Centers Associated with Increased Waitlist Mortality among Liver Candidates
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Previous studies have demonstrated decreased transplant rates among poor performing transplant centers meeting Centers for Medicare & Medicaid Services (CMS) flagging criteria. However, no…2020 American Transplant Congress
Frailty Attenuates the Gender Gap in Waitlist Mortality in Liver Transplant Candidates: A Multi-Center Study with 1,240 Patients with Cirrhosis
*Purpose: Women LT candidates experience higher rates of waitlist mortality than men. Frailty is a critical determinant of mortality in patients with cirrhosis but it…
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