2020 American Transplant Congress
One Year of COIIN Outcomes: Did Cohorts A and B Maintain Graft Survival?
United Network for Organ Sharing, Richmond, VA
*Purpose: The Collaborative Innovation and Improvement Network (COIIN) was a 3-year OPTN project aimed at increasing the utilization of kidneys with a kidney donor profile…2020 American Transplant Congress
Calculated Panel Reactive Antibody Values Increase for Kidney Transplant Candidates with HLA-DQA and HLA-DPB Unacceptable Antigens
*Purpose: Calculated panel-reactive antibody (CPRA) is the official metric of sensitization used by the United Network for Organ Sharing (UNOS) for kidney allocation. CPRA includes…2020 American Transplant Congress
Conversion to a Belatacept Based Immunosuppression Regimen in Renal Transplant Recipients
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Belatacept, a co-stimulation blocker, is an alternative anti-rejection agent that may avoid nephrotoxic or intolerable adverse effects of calcineurin inhibitor (CNI) or mammalian target…2020 American Transplant Congress
HLA Cw12 in Kidney Transplant Recipients is a Novel Risk Factor for the Development of Post-Transplantation Diabetes: A Single-Centre Retrospective Study
*Purpose: Counselling kidney transplant candidates for their personalised risk of developing post-transplantation diabetes mellitus (PTDM) requires an understanding of risk factors. While some risk factors…2020 American Transplant Congress
Crosstalk between TLR4 and HLA Class I Mediates P-Selectin Expression and Monocyte Capture to Endothelial Cells
Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA
*Purpose: Transplant recipients developing donor specific HLA antibodies (DSA) are at risk for acute and chronic antibody-mediated rejection (AMR). DSA contribute to the process of…2020 American Transplant Congress
A Multicenter, Randomized, Controlled Trial to Steer Immunosuppressive Therapy by Virus-Specific T Cells after Pediatric Kidney Transplantation (IVIST-Trial)
*Purpose: Pharmakokinetic monitoring of immunosuppressants alone is insufficient to estimate the individual intensity of immunosuppression after kidney transplantation (Tx). Virus-specific T cells (Tvis) correlate with…2020 American Transplant Congress
Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…2020 American Transplant Congress
Improving DRG Based Reimbursement to Reflect Complexity of Kidney Transplant
*Purpose: More than 90,000 individuals await a kidney transplant (KTx) in the US, yet up to 20% of recovered kidneys are discarded. Organ Transplant Centers…2020 American Transplant Congress
Molecular Phenotypes of Liver Transplant Injury: The INTERLIVER Study
1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2., ., AB, Canada
*Purpose: Liver parenchymal injury phenotypes are difficult to evaluate by histology but could be amenable to molecular assessment. Having developed a Molecular Microscope® Diagnostic System…2020 American Transplant Congress
p40 Homodimers Indirectly Induce Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts and CTLA-4ig Resistant Graft Rejection via IL-15 Signaling
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: We have reported that longer duration of cold ischemic storage (CIS) prior to transplant resulted in increased proliferation of endogenous donor-reactive CD8 T cells…
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