Abstracts Archive - Page 465 of 1683 - ATC Abstracts

2020 American Transplant Congress
Low HLA Class I Epitope Mismatch Associated with Improved Pancreas Graft Survival in Simultaneous Pancreas-Kidney Transplantation
J. M. Ladowski, M. Romine, D. Kloda, C. Young, J. Locke, V. Hauptfeld-Dolejsek, J. Houp
University of Alabama-Birmingham, Birmingham, AL
*Purpose: Antibody-mediated rejection remains the principal cause of allotransplant graft failure. Human leukocyte antigen (HLA) matching between donor and recipients significantly reduces the risk of…
2020 American Transplant Congress
Conversion to a Belatacept Based Immunosuppression Regimen in Renal Transplant Recipients
K. Paplaczyk, K. Cunningham, C. D'Agostino, D. Pinelli, J. Schulte, A. Shetty
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Belatacept, a co-stimulation blocker, is an alternative anti-rejection agent that may avoid nephrotoxic or intolerable adverse effects of calcineurin inhibitor (CNI) or mammalian target…
2020 American Transplant Congress
CD47 Innate Immune Checkpoint Enhances Islet Engraftment Following Intraportal Transplantation by Mitigating Instant Blood Mediated Inflammatory Reaction
P. Shrestha, L. Batra, M. T. Malik, M. Tan, E. S. Yolcu, H. Shirwan
Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY
*Purpose: Transplantation of islets into hepatic portal vein is associated with significant islet mass loss immediate post-transplantation. Instant blood mediated inflammatory reaction (IBMIR), characterized by…
2020 American Transplant Congress
Hemodialysis (HD) Treatment Associates with Increased Risk of Delayed Graft Function (DGF) after Renal Transplantation (RT) and Augmented Cd4 and Cd8 T Cell Proliferation Compared to Peritoneal Dialysis (PD)
A. Angeletti¹, C. Donadei¹, G. Donati¹, G. Di Certo¹, D. Conte¹, L. Gasperoni¹, E. Pelizzaro¹, C. Guglielmo¹, G. Comai¹, P. Cravedi², G. La Manna¹
¹DIMES, S.Orsola-Malpighi Hospital, Bologna University, Bologna, Italy, ²DIMES, Icahn School of Medicine at Mount Sinai, New York, NY, US, New York, NY
*Purpose: Delayed graft function (DGF) is a common event after RT that increases the risk of acute rejection and early graft loss. The impact of…
2020 American Transplant Congress
Belatacept Monthly Therapy: Transplant Recipients’ Experience
S. N. Little¹, É. N. Arsenault Knudsen², D. A. Mandelbrot¹
¹Transplant, University of Wisconsin Hospital and Clinics, Madison, WI, ²University of Wisconsin Hospital and Clinics, Madison, WI
*Purpose: While graft and patient outcomes with belatacept have been relatively well documented, the decision to use belatacept for kidney transplant recipients rests in part…
2020 American Transplant Congress
Crosstalk between TLR4 and HLA Class I Mediates P-Selectin Expression and Monocyte Capture to Endothelial Cells
Y. Jin, N. M. Valenzuela, R. A. Sosa, E. F. Reed
Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA
*Purpose: Transplant recipients developing donor specific HLA antibodies (DSA) are at risk for acute and chronic antibody-mediated rejection (AMR). DSA contribute to the process of…
2020 American Transplant Congress
Trends in Living Kidney Donation in the United States
A. Ferzola, Y. Yu, A. B. Massie, D. L. Segev, M. L. Henderson
Johns Hopkins University, Baltimore, MD
*Purpose: After peaking in 2014, the number of LKDTs per year dropped substantially in the US despite an increasing waitlist. However, trends in the KAS…
2020 American Transplant Congress
Two-Year Post-Transplant eGFR as a Surrogate Outcome of Allograft Survival in Kidney Transplant Recipients
S. Yu, E. Lee, W. Zhang, D. Segev, J. Garonzik-Wang, A. Massie
Johns Hopkins, Baltimore, MD
*Purpose: Graft failure is a major cause of morbidity and mortality in kidney transplant recipients. However, trials aimed to assess the effect of interventions on…
2020 American Transplant Congress
Allograft Repopulating Recipient B Cells after Human Intestinal Transplantation and Their Association with Donor Specific Antibody Secretion and Rejection
E. Waffarn¹, J. Fu¹, K. Frangaj¹, W. Meng², A. M. Rosenfeld², M. Li³, K. Rodgers¹, R. Vasilescu³, E. T. Luning Prak², A. Griesemer¹, T. Kato⁴, M. Martinez⁵, M. Sykes¹
¹Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, ²Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, ³Department of Pathology, Columbia University, New York, NY, ⁴Department of Surgery, Columbia University, New York, NY, ⁵Department of Pediatrics, Columbia University, New York, NY
*Purpose: Alloantibodies produced by recipient B cells are associated with rejection after intestinal transplantation (ITx) and negatively impact patient and graft survival. However, the dynamics…
2020 American Transplant Congress
Molecular Phenotypes of Liver Transplant Injury: The INTERLIVER Study
K. S. Madill-Thomsen¹, P. F. Halloran¹, &. the INTERLIVER Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: Liver parenchymal injury phenotypes are difficult to evaluate by histology but could be amenable to molecular assessment. Having developed a Molecular Microscope® Diagnostic System…