Abstracts Archive - Page 464 of 1683 - ATC Abstracts

2020 American Transplant Congress
Transient Cd4+ T Cell and Cd20+ B Cell Depletion Leads to Prolonged Pig-To-Primate Kidney Xenograft Survival
B. P. Lovasik¹, A. J. Matar¹, D. A. Faber¹, D. V. Mathews¹, C. Breeden¹, S. C. Kim¹, A. J. Tector², A. B. Adams¹
¹Emory University School of Medicine, Atlanta, GA, ²University of Miami, Miami, FL
*Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacle to clinical application of pig organ xenografts. The aim of this study…
2020 American Transplant Congress
Low HLA Class I Epitope Mismatch Associated with Improved Pancreas Graft Survival in Simultaneous Pancreas-Kidney Transplantation
J. M. Ladowski, M. Romine, D. Kloda, C. Young, J. Locke, V. Hauptfeld-Dolejsek, J. Houp
University of Alabama-Birmingham, Birmingham, AL
*Purpose: Antibody-mediated rejection remains the principal cause of allotransplant graft failure. Human leukocyte antigen (HLA) matching between donor and recipients significantly reduces the risk of…
2020 American Transplant Congress
Prevalence of Frailty and Cognitive Impairment at Time of Kidney Transplant Evaluation
J. Klein, A. Jurgensen, M. Gupta, N. Herrera, A. Gupta, D. Cibrik
Internal Medicine, Division of Nephrology, University of Kansas Medical Center, Kansas City, KS
*Purpose: Frailty is highly prevalent in kidney disease, with prevalence estimates as high as 73% in patients at the time of dialysis initiation compared to…
2020 American Transplant Congress
Factors Influencing Background Cell-Free DNA Levels: Implications for Donor-Derived Cell-Free DNA Assessment in Transplant Patients
P. Gauthier, A. Aleshin, S. Shchegrova, T. Mckenna, E. Kalashnikova, S. Sharma, H. Sethi, R. Salari, R. Swenerton, Z. Demko, B. Zimmermann, P. Billings
Natera, Inc., San Carlos, CA
*Purpose: Detecting elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the plasma of transplant recipients has been used as a metric to determine graft injury…
2020 American Transplant Congress
A Novel Polymer Product, APP-103, Reduces IRI-Induced Damage and Promotes Functional Improvement in Syngeneic Models of Renal Transplantation
K. Minami¹, S. Bae², H. Uehara¹, J. Iske¹, J. Reder³, H. Azuma⁴, A. Weins¹, E. Van Keuren⁵, B. Houser³, A. El-Khal¹, P. Kang², S. Tullius¹
¹Brigham and Women's Hospital, Boston, MA, ²Beth Israel Deaconess Medical Center, Boston, MA, ³Celdara Medical, Lebanon, NH, ⁴Osaka Medical College, Osaka, Japan, ⁵Georgetown University, Washington DC, DC
*Purpose: Our data introduce APP-103 as a novel, non-toxic and site-activating therapeutic approach that effectively ameliorates the consequences of ischemia/reperfusion injury in solid organ transplantation.*Methods:…
2020 American Transplant Congress
CD47 Innate Immune Checkpoint Enhances Islet Engraftment Following Intraportal Transplantation by Mitigating Instant Blood Mediated Inflammatory Reaction
P. Shrestha, L. Batra, M. T. Malik, M. Tan, E. S. Yolcu, H. Shirwan
Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY
*Purpose: Transplantation of islets into hepatic portal vein is associated with significant islet mass loss immediate post-transplantation. Instant blood mediated inflammatory reaction (IBMIR), characterized by…
2020 American Transplant Congress
Outcomes of Kidney Transplant Recipients with Depression and Anxiety
D. Keys, S. Jackson, S. M. Riad, R. Spong, A. Matas
University of Minnesota, Minneapolis, MN
*Purpose: The outcomes of kidney transplantation in patients with depression and anxiety have been limited by small numbers. This is despite high prevalence of these…
2020 American Transplant Congress
2-Year Results of a Naturalistic Study of De Novo Extended-Release Tacrolimus Tablets vs. Tacrolimus Immediate-Release Capsules in Kidney Transplant Recipients
J. Hagopian¹, S. January¹, N. Nesselhauf¹, K. Progar¹, T. Horwedel², R. Delos Santos³
¹Barnes-Jewish Hospital, Saint Louis, MO, ²Veloxis Pharmaceuticals, Cary, NC, ³Washington University, Saint Louis, MO
*Purpose: In December 2015, our center instituted a protocol change moving to de novo use of tacrolimus-XR (LCPT). The objective of this extension study is…
2020 American Transplant Congress
Flagging of Transplant Centers Associated with Increased Waitlist Mortality among Liver Candidates
R. L. Grant, B. A. Shelton, P. A. MacLennan, R. D. Reed, R. M. Cannon, B. J. Orandi, D. E. Eckhoff, J. E. Locke
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Previous studies have demonstrated decreased transplant rates among poor performing transplant centers meeting Centers for Medicare & Medicaid Services (CMS) flagging criteria. However, no…
2020 American Transplant Congress
Trends in Living Kidney Donation in the United States
A. Ferzola, Y. Yu, A. B. Massie, D. L. Segev, M. L. Henderson
Johns Hopkins University, Baltimore, MD
*Purpose: After peaking in 2014, the number of LKDTs per year dropped substantially in the US despite an increasing waitlist. However, trends in the KAS…