Abstracts Archive - Page 461 of 1683 - ATC Abstracts

2020 American Transplant Congress
Factors Influencing Background Cell-Free DNA Levels: Implications for Donor-Derived Cell-Free DNA Assessment in Transplant Patients
P. Gauthier, A. Aleshin, S. Shchegrova, T. Mckenna, E. Kalashnikova, S. Sharma, H. Sethi, R. Salari, R. Swenerton, Z. Demko, B. Zimmermann, P. Billings
Natera, Inc., San Carlos, CA
*Purpose: Detecting elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the plasma of transplant recipients has been used as a metric to determine graft injury…
2020 American Transplant Congress
Anti-Thymocyte Globulins Induced Immunomodulatory Effect and Increased Regulatory T Cell in a In Vitro Model of Allogeneic Cell Coculture
M. Colladant¹, J. Lion², P. Saas³, S. Perruche³, D. Ducloux¹, N. Mooney², J. Bamoulid¹
¹Nephrologie, Dialyse et Transplantation, CHU de Besançon, Besancon, France, ²Equipe INSERM: Endothelium, Inflammation et Alloreactivity INSERM UMR-S 976, Paris, France, ³INSERM U1098 RIGHT, Université de Franche-Comté EFS Bourgogne Franche-Comté, Besancon, France
*Purpose: Two types of Anti-Thymocyte Globulins (ATG) are commonly used in renal transplantation (Thymoglobuline and Grafalon) and induce severe, dose-dependent and sometimes persistent CD4+ T…
2020 American Transplant Congress
Assessment of Deceased Donor Kidney and Liver Surgical Recovery Error Rates
R. D. Hasz, S. M. West, H. M. Nathan
Gift of Life Donor Program, Philadelphia, PA
*Purpose: There is no nationally available data related to the incidence of surgical errors in deceased donor organ recoveries or its impact on organ discard…
2020 American Transplant Congress
2-Year Results of a Naturalistic Study of De Novo Extended-Release Tacrolimus Tablets vs. Tacrolimus Immediate-Release Capsules in Kidney Transplant Recipients
J. Hagopian¹, S. January¹, N. Nesselhauf¹, K. Progar¹, T. Horwedel², R. Delos Santos³
¹Barnes-Jewish Hospital, Saint Louis, MO, ²Veloxis Pharmaceuticals, Cary, NC, ³Washington University, Saint Louis, MO
*Purpose: In December 2015, our center instituted a protocol change moving to de novo use of tacrolimus-XR (LCPT). The objective of this extension study is…
2020 American Transplant Congress
Livers from Donation after Cardiac Death (DCD) Offer – Accept or Decline?
T. Ishaque, M. G. Bowring, J. D. Motter, Y. Yu, S. Yu, A. B. Kernodle, J. G. Wang, S. Getsin, D. L. Segev, A. B. Massie
Johns Hopkins University, Baltimore, MD
*Purpose: Given the shortage of deceased-donor livers, donation after cardiac death (DCD) provides an opportunity to expand the donor pool. Due to concern over the…
2020 American Transplant Congress
CD47 Innate Immune Checkpoint Enhances Islet Engraftment Following Intraportal Transplantation by Mitigating Instant Blood Mediated Inflammatory Reaction
P. Shrestha, L. Batra, M. T. Malik, M. Tan, E. S. Yolcu, H. Shirwan
Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY
*Purpose: Transplantation of islets into hepatic portal vein is associated with significant islet mass loss immediate post-transplantation. Instant blood mediated inflammatory reaction (IBMIR), characterized by…
2020 American Transplant Congress
Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
J. B. Alhaddad, H. Allos, B. S. Al Dulaijan,, S. K. Eskandari, I. Sulkaj, G. Melhem, J. Y. Choi, J. R. Azzi
Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…
2020 American Transplant Congress
To Wait or Not to Wait: The Survival Benefit of Preemptive Kidney Transplantation after Accounting for Lead Time Bias
S. Yu¹, A. Kernodle¹, J. Snyder², J. Garonzik-Wang¹, D. Segev¹, A. Massie¹
¹Johns Hopkins, Baltimore, MD, ²SRTR, Minneapolis, MN
*Purpose: Over 2,000 preemptive living donor kidney transplants (LDKT) per year are performed in the US. Preemptive LDKT allows recipients to avoid dialysis, but increases…
2020 American Transplant Congress
Does Hope for a Better Future or Fear of Death Motivate Kidney Patients More? A Decisional Balance Exploration of Motivation to Pursue Living Donor Kidney Transplant
H. Rafiqzad¹, A. Wasim¹, A. Rezaeishahreza¹, J. Lam¹, A. Li¹, T. Mahiuddin¹, A. D. Waterman², M. Novak¹, I. Mucsi¹
¹University Health Network, Toronto, ON, Canada, ²University of California, Los Angeles, Los Angeles, CA
*Purpose: We assessed whether the importance attributed to “living a longer life with transplant” versus “fear of death during transplant surgery” by kidney transplant (KT)…
2020 American Transplant Congress
A Novel Polymer Product, APP-103, Reduces IRI-Induced Damage and Promotes Functional Improvement in Syngeneic Models of Renal Transplantation
K. Minami¹, S. Bae², H. Uehara¹, J. Iske¹, J. Reder³, H. Azuma⁴, A. Weins¹, E. Van Keuren⁵, B. Houser³, A. El-Khal¹, P. Kang², S. Tullius¹
¹Brigham and Women's Hospital, Boston, MA, ²Beth Israel Deaconess Medical Center, Boston, MA, ³Celdara Medical, Lebanon, NH, ⁴Osaka Medical College, Osaka, Japan, ⁵Georgetown University, Washington DC, DC
*Purpose: Our data introduce APP-103 as a novel, non-toxic and site-activating therapeutic approach that effectively ameliorates the consequences of ischemia/reperfusion injury in solid organ transplantation.*Methods:…