Abstracts Archive - Page 458 of 1683 - ATC Abstracts

2020 American Transplant Congress
Perioperative Anticoagulation Decreases Graft Thrombosis in Pancreas Transplantation
N. M. Handy¹, L. Skoval¹, J. Wingate², C. Kuhr³, N. Cowan³, J. Brandenberger¹
¹Section of General, Thoracic, and Vascular Surgery, Virginia Mason Medical Center, Seattle, WA, ²Department of Urology, Madigan Army Medical Center, Tacoma, WA, ³Section of Urology, Virginia Mason Medical Center, Seattle, WA
*Purpose: Pancreas transplant thrombosis is the most common cause of graft failure in the early postoperative period, occurring 5-20% of cases. Bleeding (which occurs ~30%…
2020 American Transplant Congress
HCV-Positive Donors Are Healthier and Inequitably Utilized in the United States
B. L. Da, T. Kushner, G. Kakked, J. Crismale, G. Ezaz, T. Schiano, B. Saberi
Liver Disease, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Increased utilization of HCV-positive (HCV+) liver allografts has been endorsed as a solution to the national organ shortage. Due to the opioid epidemic, there…
2020 American Transplant Congress
Targeting the CD40/CD40L Axis in Sensitized Nonhuman Primate Allotransplantation
Z. W. Fitch, R. Schmitz, M. Manook, A. Y. Choi, J. Yoon, J. Kwun, S. J. Knechtle
Duke University, Durham, NC
*Purpose: Blockade of the CD28/B7 costimulation pathway has shown great promise as part of desensitization and maintenance immunosuppression regimens in our sensitized nonhuman primate model.…
2020 American Transplant Congress
Profiling Non-HLA Antibodies in Antibody-Mediated Rejection Following Cardiac Transplantation
S. B. See¹, B. S. Mantell², K. J. Clerkin³, B. Ray⁴, E. R. Vasilescu⁵, C. Marboe⁵, Y. Naka⁶, S. Restaino³, P. C. Colombo³, L. Addonizio², M. A. Farr³, E. Zorn¹
¹Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, ²Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, ³Department of Medicine, Columbia University Irving Medical Center, New York, NY, ⁴Research and Development, Immucor, Waukesha, WI, ⁵Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, ⁶Department of Surgery, Columbia University Irving Medical Center, New York, NY
*Purpose: Antibody-mediated rejection (AMR) driven by the development of donor-specific antibodies (DSA) directed against mismatched donor HLA is a major risk factor for graft loss…
2020 American Transplant Congress
Transcriptomic Profiling of Paired Serum and Biopsy Samples from FSGS Patients
C. Kuscu¹, M. Kiran², A. Wolen¹, C. Kuscu¹, A. Bajwa¹, J. Eason¹, D. Maluf¹, E. Akalin³, V. Mas¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, ²Department of Systems and Computational Biology, University of Hyderabad, Hyderabad, India, ³Department of Medicine and Surgery, Albert Einstein College of Medicine, New York, NY
*Purpose: Pathogenesis and molecular footprints of focal segmental glomerulosclerosis (FSGS) after kidney transplantation whether it is primary or secondary is unknown. Herein, we studied a…
2020 American Transplant Congress
Tyrosine Receptor Kinase Axl Regulates Intragraft Trafficking of Alloreactive T Cells Post Kidney Transplantation
A. Dangi¹, K. Glinton², M. Sharma¹, S. Yu¹, M. DeBerge², E. B. Thorp², X. Luo¹
¹Nephrology/Medicine, Duke University, Durham, NC, ²Pathology, Northwestern University, Chicago, IL
*Purpose: Previous studies have shown that receptor tyrosine kinase Axl, primarily expressed on dendritic cells and some tissue-specific macrophage population, is required for T cells…
2020 American Transplant Congress
Novel Insights Into High Alloantibody Production in CCR5 KO Recipient Mice
J. L. Han¹, J. M. Zimmerer², Q. Zeng³, B. A. Ringwald¹, C. K. Breuer³, G. L. Bumgardner²
¹Ohio State University, Columbus, OH, ²Transplant Surgery, Ohio State University, Columbus, OH, ³Nationwide Children's Hospital, Columbus, OH
*Purpose: Antibody-mediated rejection (AMR) contributes to both early and late kidney allograft loss. Unfortunately, conventional immunosuppressants do not effectively control development of humoral alloimmunity in…
2020 American Transplant Congress
Recipient LAG3 Deficiency Results in Antibody-Mediated Rejection of Mouse Renal Allografts
M. Nicosia, R. Fan, J. Lee, V. Gorbacheva, A. Beavers, N. Dvorina, W. M. Baldwin III, R. L. Fairchild, B. Min, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Lymphocyte activation gene-3 (LAG3) is a coinhibitory receptor on the surface of T and B lymphocytes, NK cells and plasmacytoid dendritic cells. Its functions…
2020 American Transplant Congress
A Single-Cell Transcriptome Atlas of 15 Adult Human Organs
Z. Guo¹, S. He², L. Wang¹, Y. Liu², J. Xu¹, J. Bei², X. He¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²The Cancer Centre of Sun Yat-Sen University, Guangzhou, China
*Purpose: The transcriptome diversity of cell types within and across tissues is of great importance for biological function of human beings. Here we conducted a…
2020 American Transplant Congress
CD4+ T-Cells Express High Levels of Messenger RNA Coding for Heparanase in Cultures with Matrigel
N. Chai, G. Wu, I. Kim, S. Jordan, A. Klein, T. Brennan
Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: Heparanase (Hpse) is the sole heparan sulfate (HS) degrading enzyme regulating multiple biological activities that enhance immune cell migration, blood vessel growth and cell…