Abstracts Archive - Page 456 of 1683 - ATC Abstracts

2020 American Transplant Congress
Undernutrition and Hypoleptinemia Modulate Cytomegalovirus Infection
E. David¹, M. Zhu², W. Parker², N. MacIver¹, A. D. Kirk², E. T. Chambers¹
¹Pediatrics, Duke University, Durham, NC, ²Surgery, Duke University, Durham, NC
*Purpose: Cytomegalovirus (CMV) viremia/infection remains a significant cause of morbidity in transplantation, especially in the undernourished population. Undernutrition and hypoleptinemia have been implicated in other…
2020 American Transplant Congress
The Effect of Undernutrition and Immunosuppression on Cytomegalovirus Specific T Cell Responses
E. David¹, M. Zhu², W. Parker², N. MacIver¹, A. D. Kirk², E. T. Chambers¹
¹Pediatrics, Duke University, Durham, NC, ²Surgery, Duke University, Durham, NC
*Purpose: Cytomegalovirus (CMV) infection remains a significant issue in transplantation, especially in those who are undernourished. While undernutrition is associated with impaired T cell immunity…
2020 American Transplant Congress
Dissecting Humoral Alloimmune Sensitization: A Dynamic Interplay of Different Cellular Compartments
A. Torija, A. Favà, E. Crespo, M. Jarque, M. Meneghini, N. Bolaños, J. Grinyo, O. Bestard
Kidney transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain
*Purpose: Humoral alloimmune memory is the main barrier for successful transplantation and is generated by a complex and compartmentalized B-cell immune response. Understanding the role…
2020 American Transplant Congress
Ikaros Regulates Macrophage Inflammation in Liver Ischemia-Reperfusion Injury: From Mouse-to-Human
K. Kadono¹, S. Kageyama¹, K. Nakamura¹, H. Hirao¹, H. Kojima¹, T. Ito¹, K. J. Dery¹, X. Li², R. W. Busuttil¹, F. Kaldas¹, J. W. Kupiec-Weglinski¹
¹Liver Transplant Surgery, UCLA, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor for early allograft dysfunction and rejection episodes in liver transplantation (LT). The impact of Ikaros,…
2020 American Transplant Congress
Agonistic Anti-CD272 Antibody (6B2) Suppressed Donor Specific Antibody Through Inducible Regulatory T Cells
Y. Yamamoto¹, M. Uchiyama², K. Uchida³, H. Yagita⁴, M. Niimi¹
¹Surgery, Teikyo University, Tokyo, Japan, ²Cardiovascular Surgery, Teikyo University, Tokyo, Japan, ³Hepato- Biliary- Pancreatic Surgery, Juntendo University, Tokyo, Japan, ⁴Immunology, Juntendo University, Tokyo, Japan
*Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) is a coinhibitory molecule and may play an important role in alloimmune responses. We…
2020 American Transplant Congress
Decreased Anti-Tumor Activity of Liver-Resident NK Cells via IL-33 Associated with Portal Hypertension after Living Donor Liver Transplantation
Y. Imaoka, M. Ohira, K. Sato, H. Ohdan
Hiroshima Uni., Hiroshima, Japan
*Purpose: It has been reported that increasing portal vein pressure after living donor liver transplantation (LDLT) was associated with a poor prognosis, risk factors for…
2020 American Transplant Congress
Everolimus-Treatment Inhibits the Transition of the Immature Subsets of Liver Natural Killer Cells to Mature State and Enhances Anti-Tumor Activity
Y. Tanaka, J. Saparbay, H. Ohdan
Gastreenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: The immunosuppressive regimen currently used after organ transplantation efficiently reduces the adaptive immune components. During suppressed adaptive immunity, the innate immune cells may play…
2020 American Transplant Congress
A Novel Immunoresponse Monitoring System to Predict Chronic Antibody- Mediated Rejection in Kidney Transplant Recipients
N. Iwahara¹, K. Hotta¹, D. Iwami¹, Y. Takada¹, H. Higuchi², H. Sasaki², T. Tanabe², N. Shinohara¹
¹Hokkaido University, Sapporo, Japan, ²Sapporo City General Hospital, Sapporo, Japan
*Purpose: Chronic active antibody mediated rejection (CAAMR) induced by de novo donor specific antibodies (DSA) is the main cause of graft loss in the long-term.…
2020 American Transplant Congress
Lack of Dj-1 Amplifies Sepsis-Associated Acute Kidney Injury and Increases Parenchymal Apoptosis
J. Leeds¹, Y. Scindia², E. Ghias¹, S. Cechova¹, V. Loi¹, E. Mandziak¹, S. Swaminathan¹
¹University of Virginia, Charlottesville, VA, ²University of Florida, Gainesville, FL
*Purpose: Sepsis following kidney transplantation is a frequent complication due to mandatory immunosuppression and increased infection risk. Kidney transplant recipients who develop sepsis show inferior…
2020 American Transplant Congress
Inducing Donor MHC Chimerism with Bone Marrow Derived Exosomes in Non-Human Primates
P. M. Patel¹, B. A. Gonzalez Nolasco¹, J. A. Morrissette¹, A. Prunevieille¹, K. J. Ahrens¹, J. M. O¹, D. C. Becerra¹, G. Benichou¹, J. C. Madsen²
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Cardiac allograft tolerance in non-human primates (NHPs) has been achieved by our group via hematopoietic mixed chimerism consisting of an allogeneic bone marrow (BM)…