Abstracts Archive - Page 456 of 1683 - ATC Abstracts

2020 American Transplant Congress
Broader Distribution of Kidneys Not Projected to Systematically Favor “Low” Performing OPOs
A. Wilk¹, S. Gustafson², D. Stewart¹, N. Salkowski², D. Zaun², J. Snyder²
¹UNOS, Richmond, VA, ²Hennepin Healthcare Research Institute, Minneapolis, MN
*Purpose: In August 2019, the OPTN Kidney (KI) Transplantation Committee put forth a proposal for public comment to replace DSA and region from KI allocation…
2020 American Transplant Congress
Activated CD27⁺CD21^– Subset Dominate the Memory B Cell Response During Antibody-Mediated Rejection of Kidney Allografts
K. Louis¹, E. Bailly¹, C. Macedo¹, M. Marrari¹, M. Yamada¹, P. Randhawa¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Inserm UMR 976, Paris, France
*Purpose: The role of alloreactive memory B (mB) cells in the pathogenesis of antibody-mediated rejection (ABMR) is increasingly recognized. Yet, a comprehensive characterization of mB…
2020 American Transplant Congress
Biointegration and Function of 3D Printed Bionic Pancreatic Petals on a Mouse Model
M. Wszola¹, M. Klak¹, G. Tymicki¹, A. Berman¹, K. Kosowska¹, T. Bryniarski¹, P. Cywoniuk¹, M. Gomolka¹, P. Kowalska¹, P. Turowski¹, A. Kaminski²
¹Foundation for Research and Science Development, Warsaw, Poland, ²Medical University of Warsaw, Warsaw, Poland
*Purpose: Despite the technologically advanced integrated systems of continuous glycemic control and insulin supply, it is still impossible to obtain results of diabetes treatment in…
2020 American Transplant Congress
Production of Detergent-Free ECM-Derived Bioinks for Bioprinting of Bionic Pancreas Ready for Clinical Use
M. Wszola¹, M. Klak¹, G. Tymicki¹, A. Berman¹, K. Kosowska¹, T. Bryniarski¹, P. Cywoniuk¹, M. Gomolka¹, P. Kowalska¹, P. Turowski¹, A. Kaminski²
¹Foundation for Research and Science Development, Warsaw, Poland, ²Medical University of Warsaw, Warsaw, Poland
*Purpose: Bioprinting is the process of creating 3D tissue analogues. For this purpose, it is necessary to produce a special bioink that will be able…
2020 American Transplant Congress
Construction of Three-Dimensional Vascularized Functional Beta-Cells Tissues Using a Layer-by-Layer Cell Coating Technique
S. Takaichi¹, T. Akagi², Y. Tomimaru¹, S. Kobayashi¹, Y. Iwagami¹, H. Akita¹, T. Noda¹, K. Gotoh¹, Y. Doki¹, M. Akashi², H. Eguchi¹
¹Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan, ²Building Block Science Joint Research Chair, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan
*Purpose: Regenerative therapy for type I Diabetes Mellitus has been expected to be a promising treatment. A subcutaneous site is an ideal candidate for stem…
2020 American Transplant Congress
Natural Antibodies and Left Ventricular Assist Device Complications
S. B. See¹, D. Onat², E. Hittesdorf³, F. McDougan⁴, M. Yuzefpolskaya², V. K. Topkara², Y. Naka⁵, H. Takayama⁵, K. Takeda⁵, G. Milligan⁶, D. Wencker⁶, S. Hall⁶, M. Askar⁶, P. Kimball⁴, G. Wagener³, P. C. Colombo², E. Zorn¹
¹Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, ²Department of Medicine, Columbia University Irving Medical Center, New York, NY, ³Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, ⁴Department of Transplant Surgery, Virginia Commonwealth University, Richmond, VA, ⁵Department of Surgery, Columbia University Irving Medical Center, New York, NY, ⁶Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, TX
*Purpose: Left ventricular assist device (LVAD) implantation is followed by a sharp increase in serum levels of IgG natural antibodies (Nabs) recognizing oxidation-specific epitopes (OSE)…
2020 American Transplant Congress
Ex Vivo Generated Regulatory B Cells Can Suppress Donor-Specific CD4 T Cells Proliferation In Vivo
G. Huai¹, K. M. Lee¹, Q. Fu¹, K. Deng¹, N. J. Feeney¹, C. Leguern¹, N. Tanimine¹, C. G. Rickert¹, S. Deng², J. F. Markmann¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Organ Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
*Purpose: B cells expanded in vitro via TLR9 agonist CpG and activated by LPS, PMA and ionomycin have been previously denoted “TLR-Bregs” by our team.…
2020 American Transplant Congress
Naïve B Cells Regulation by TLR-Breg Cells In Vitro
Q. Fu, K. Lee, G. Huai, K. Deng, N. J. Feeney, C. Leguern, S. Deng, J. F. Markmann
Center for Transplant Science, MGH, Boston, MA
*Purpose: Regulatory B cells (Bregs) have shown great potential in cell therapies for murine organ transplantation by inhibiting the proliferation of cytotoxic and helper T…
2020 American Transplant Congress
Irf8-Relevant Mechanism in B Cell Regulation In Vitro
Q. Fu¹, K. Deng², H. Yang¹, J. F. Markmann², S. Deng¹
¹Organ Transplantation Center, and School of Medicine, University of Electronic Sciences and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, MGH, Boston, MA
*Purpose: Previously, we had reported that IFN regulatory factor 8 (IRF8) could be used for the identification of interstitial fibrosis and tubular atrophy (IFTA) with…
2020 American Transplant Congress
Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury
V. Gorbacheva, R. Fan, S. Miyairi, W. Baldwin, R. Fairchild, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Multiple clinical and pre-clinical studies describe correlations between de novo autoimmune responses and poor transplant outcome. We have previously reported that following renal transplantation,…