Abstracts Archive - Page 452 of 1683 - ATC Abstracts

2020 American Transplant Congress
ABO Self-Tolerance in a Mouse Model: Evidence of Tolerance at B Cell but Not T Cell Level
I. Adam, B. Motyka, K. Tao, L. West
Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada
*Purpose: We showed that human infants become tolerant to donor A/B-antigens (Ag) after ABO-incompatible heart transplantation (ABOi-HTx) by mechanisms not well-defined. To expand ABOi-HTx effectively…
2020 American Transplant Congress
Irf8-Relevant Mechanism in B Cell Regulation In Vitro
Q. Fu¹, K. Deng², H. Yang¹, J. F. Markmann², S. Deng¹
¹Organ Transplantation Center, and School of Medicine, University of Electronic Sciences and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, MGH, Boston, MA
*Purpose: Previously, we had reported that IFN regulatory factor 8 (IRF8) could be used for the identification of interstitial fibrosis and tubular atrophy (IFTA) with…
2020 American Transplant Congress
Characterization of a Novel CD8⁺ B Cell Subset in Monkeys Tolerant of Heart Allografts
J. A. Morrissette¹, K. Pruner¹, S. Lee¹, J. Paster¹, W. Sommer¹, J. O¹, I. Hanekamp¹, P. Sage², G. Benichou¹, J. C. Madsen³
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, ²Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Center for Transplantation Sciences, Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: We have previously reported that transient mixed hematopoietic chimerism induced via donor bone marrow transplantation can achieve tolerance to cardiac allografts in non-human primates…
2020 American Transplant Congress
Analysis of the Mechanism of Liver-Resident NK Cells Activity via the Aryl Hydrocarbon Receptor
K. Sato, M. Ohira, Y. Imaoka, H. Ohdan
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: Tumor recurrence is the main limitation of liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). We previously reported an adoptive immunotherapy approach that…
2020 American Transplant Congress
Novel Insights Into High Alloantibody Production in CCR5 KO Recipient Mice
J. L. Han¹, J. M. Zimmerer², Q. Zeng³, B. A. Ringwald¹, C. K. Breuer³, G. L. Bumgardner²
¹Ohio State University, Columbus, OH, ²Transplant Surgery, Ohio State University, Columbus, OH, ³Nationwide Children's Hospital, Columbus, OH
*Purpose: Antibody-mediated rejection (AMR) contributes to both early and late kidney allograft loss. Unfortunately, conventional immunosuppressants do not effectively control development of humoral alloimmunity in…
2020 American Transplant Congress
Targeting the CD40/CD40L Axis in Sensitized Nonhuman Primate Allotransplantation
Z. W. Fitch, R. Schmitz, M. Manook, A. Y. Choi, J. Yoon, J. Kwun, S. J. Knechtle
Duke University, Durham, NC
*Purpose: Blockade of the CD28/B7 costimulation pathway has shown great promise as part of desensitization and maintenance immunosuppression regimens in our sensitized nonhuman primate model.…
2020 American Transplant Congress
Modulating ITK Signaling Facilitate Allogeneic Skin Engraftment and Clear LCMV Viruses by Regulating IRF-4, JAK STAT and Eomes Expression
M. Mammadli¹, M. Karimi¹, S. Mahmudlu¹, A. August², W. Huang²
¹Microbiology and Immunology, Upstate Medical University, Syracuse, NY, ²Microbiology and Immunology, Cornell University, Ithaca, NY
*Purpose:Solid organ transplantation is a life-saving procedure to treat end-stage organ failure. However, transplantation of organs between genetically distinct individuals results in acute graft rejection…
2020 American Transplant Congress
Recipient LAG3 Deficiency Results in Antibody-Mediated Rejection of Mouse Renal Allografts
M. Nicosia, R. Fan, J. Lee, V. Gorbacheva, A. Beavers, N. Dvorina, W. M. Baldwin III, R. L. Fairchild, B. Min, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Lymphocyte activation gene-3 (LAG3) is a coinhibitory receptor on the surface of T and B lymphocytes, NK cells and plasmacytoid dendritic cells. Its functions…
2020 American Transplant Congress
Lymphotoxin Beta Receptor Regulates Draining Lymph Node Structure and Treg Migration
V. Saxena¹, W. Piao¹, L. Li¹, Y. Xiong¹, C. C. Palusckievicz¹, T. Simon¹, M. W. Shirkey¹, R. Abdi², J. S. Bromberg¹
¹University of Maryland, Baltimore, Baltimore, MD, ²Harvard U, Boston, MA
*Purpose: To induce tolerance, regulatory T cells (Treg) are required to migrate from tissues via afferent lymphatic vessels (LV) to the draining lymph node (dLN).…
2020 American Transplant Congress
Strong Engagement of CD137 Suppresses Graft-Versus-Host Disease Through Dendritic Cells
H. Cho¹, J. Lee², B. Kwon³, S. Park⁴, H. Park⁴, K. Yoo², K. Park², J. Kim³, S. Kang³
¹Ulsan University Hospital, Ulsan, Korea, Republic of, ²Nephrology, Ulsan University Hospital, Ulsan, Korea, Republic of, ³Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, ⁴Surgery, Ulsan University Hospital, Ulsan, Korea, Republic of
*Purpose: We previously demonstrated that anti-CD137 agonist prevent acute graft-versus-host disease (GVHD) and chronic GVHD in the parent-into-unirradiated F1 acute or chronic GVHD model. Although…