ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Leveraging Single-Cell Signatures in Kidney Transplant Biopsies Uncovers Immunological Heterogeneity Within Rejection Phenotypes

    J. Callemeyn1, B. Lamarthée1, P. Koshy2, T. Debyser3, E. Van Loon1, A. Franken4, T. Van Brussel4, I. Arijs4, D. Lambrechts4, M. Rabant5, A. Senev1, T. Vaulet6, C. Tinel1, M. Naesens1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium, 3Faculty of Medicine, KU Leuven, Leuven, Belgium, 4Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, 5Necker-Enfants Malades Institute, Institut national de la santé et de la recherche médicale (Inserm), Université de Paris, Paris, France, 6ESAT Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium

    *Purpose: Rejection of the kidney allograft is hallmarked by the accumulation of inflammatory cells within the renal architecture, leading to microvascular or tubulointerstitial inflammation. However,…
  • 2022 American Transplant Congress

    Axl and MerTK Regulate the Activation of Liver Ischemia Reperfusion Injury by Upregulating Il-13 in Kupffer Cells

    J. Zhang1, M. Ni1, H. Zhang1, R. Busuttil1, J. Kupiec-Weglinski1, X. Wang2, J. Jin3, Y. Zhai1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3Guilin Medical University, Guilin, China

    *Purpose: Ischemia reperfusion injury (IRI) remains an unresolved clinical problem. A sterile inflammatory response drives the disease pathogenesis. Although mechanisms of liver innate immune activation…
  • 2022 American Transplant Congress

    Bone Fractures Are Not Increased in Older Prior Living Kidney Donors

    H. Amer1, H. Maradit Kremers1, D. Larson1, I. Zaniletti1, W. K. Kremers1, A. Matas2, B. Kasiske3, S. Khosla1, R. Kumar1

    1Mayo Clinic, Rochester, MN, 2University of Minnesota, Minneapolis, MN, 3Hennepin County Medical Center, Minneapolis, MN

    *Purpose: Living kidney donors were shown to have derangements of bone biomarkers resembling those occurring in early chronic kidney disease within 36 months of donation.…
  • 2022 American Transplant Congress

    Renal Transplantation and Statins Effects on Dyslipidemia in Renal Transplant Recipients

    Z. Arabi, A. Alghamdi, A. Alnasrullah, A. R. Altheaby, M. Tawhari, N. Alnazari

    KAMC, Riyadh, Saudi Arabia

    *Purpose: to review the effect of renal transplantation and adding of statins on dyslipidemia in renal transplant recipients.*Methods: A single center experience retrospective study of…
  • 2022 American Transplant Congress

    Time-Dependent Blood Eosinophilia Count Increases the Risk of Kidney Allograft Rejection

    L. Colas1, L. Bui2, C. Kerleau3, M. Lemdani4, K. Autain-Renaudin5, A. Magnan6, M. Giral3, S. Brouard1

    1CRT2I, Université de Nantes, Nantes, France, 2Service de Néphrologie, Centre Hospitalier de Mouscron, Mouscron, Belgium, 3Service de Néphrologie et Immunologie Clinique, CHU de Nantes, Nantes, France, 4Département de Biomathématiques, Université de Lilles, Lilles, France, 5Service d'Anatomie et Cytologie Pathologique, CHU de Nantes, Nantes, France, 6INRAe UMR 0892, Université de Versailles Saint-Quentin Paris-Saclay, Paris, France

    *Purpose: There is growing evidence that type 2 immune effectors (immunoglobulin E, eosinophils, mast cells/basophils) play a role in autoimmune disorders and solid organ transplantation.…
  • 2022 American Transplant Congress

    Access to Pediatric Kidney Transplant: The Impact of Mental Health Diagnoses and Social Determinants of Health

    E. Blanchette1, E. Benz1, J. Armendariz1, K. McKinnon1, M. Chandran2, E. S. Christofferson1, M. Bisek1, M. Bock1

    1Children's Hospital Colorado, Aurora, CO, 2Pharmacy, UNC Hospitals, Chapel Hill, NC

    *Purpose: Limited and delayed access to kidney transplant (KT) has been associated with characteristics of adult KT candidates, including mental health (MH) diagnoses, negative social…
  • 2022 American Transplant Congress

    What If Only Days After Dialysis Counted Towards Kidney Candidates’ Qualified Waiting Times?

    G. R. Vece, K. Lindblad, M. Stuart, B. Carrico, D. Stewart, D. Klassen, S. Diallo

    Research, United Network for Organ Sharing, Richmond, VA

    *Purpose: Current kidney policy allows patients who have not yet initiated dialysis to qualify for allocation priority based on the time since a recorded eGFR…
  • 2022 American Transplant Congress

    Impact of Graft Type, Presence and Type of Inflammatory Bowel Disease on Outcomes Following Liver Transplantation for Primary Sclerosing Cholangitis

    S. Kumar1, S. Lin2, J. D. Schold3

    1Digestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates, 2Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, 3Center for Populations Health Research, Cleveland Clinic Foundation, Cleveland, OH

    *Purpose: In Primary sclerosing cholangitis (PSC), concerns exist regarding outcomes following donation after circulatory death (DCD) liver transplantation (LT) due to risk of ischemic cholangiopathy…
  • 2022 American Transplant Congress

    Association Between Allograft Gene Expression and Acute Cellular Rejection Grade in Heart Transplant Recipients

    A. Kao1, K. Haffey2, K. T. Gondi3, J. Linard2, C. Knutson2, K. Morgan2, L. Teterina2, S. Williams2, K. Oreschak4, H. Zhang4

    1St. Luke's Health System Kansas City Mid America Heart Institute, Kansas City, MO, 2St. Luke's, Kansas City, MO, 3University of Michigan, Ann Arbor, MI, 4CareDx, South San Francisco, CA

    *Purpose: Endomyocardial biopsy (EMB) remains the gold standard in acute rejection (AR) surveillance in heart transplantation (HT) despite interpretation subjectivity and low concordance rates between…
  • 2022 American Transplant Congress

    Outcomes Following Renal Transplant with Hepatitis C Viremic Donors in an Elderly Veteran Population with Preemptive Mayvret Therapy

    R. Lopez-Soler1, A. Thorndyke1, C. Trotter1, A. Abadier2, M. Samra1

    1Surgery, Transplantation, Edward Hines Jr. Veterans Administration Hospital, Hines, IL, 2Surgery, Loyola University School of Medicine, Maywood, IL

    *Purpose: Overall mortality on the kidney transplant waiting list is higher for older diabetic patients. The average age of waitlisted veteran patients is 64, with…
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