ATC Abstracts

American Transplant Congress abstracts

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  • 2020 American Transplant Congress

    Microbiota Modulates Ischemia-Reperfusion Injury in Mouse Liver Transplantation

    S. Kageyama1, H. Kojima1, K. Kadono1, H. Hirao1, K. J. Dery1, K. Nakamura2, T. Dong3, J. Jacobs3, R. W. Busuttil1, J. W. Kupiec-Weglinski1

    1Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, 2Surgery, Nishi Kobe Medical Center, Kobe, Japan, 3The Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, Los Angeles, CA

    *Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor in orthotopic liver transplantation (OLT). As host microbiota may associate with health or disease, antibiotics (Abx)…
  • 2020 American Transplant Congress

    The Histological Picture of Indication Biopsies in the First Days after Renal Transplantation

    E. Van Loon, M. Coemans, A. Senev, D. Kuypers, M. Emonds, M. Naesens

    Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium

    *Purpose: In preclinical studies, ischemia reperfusion injury and older donor age are associated with renal inflammation in the early phase after transplantation. In human kidney…
  • 2020 American Transplant Congress

    Ex Vivo Pumping Through an OPO’s Eyes

    A. L. Friedman, E. Marquez

    LiveOnNY, New York, NY

    *Purpose: A single, large organ procurement organization (OPO) sought to document the use of extra-renal ex vivo pumping in the management of the deceased donor…
  • 2020 American Transplant Congress

    Development of a Split Liver Machine Perfusion Protocol to Provide Comparative Controls in Assessing Therapeutic Interventions

    J. A. Attard1, L. Wallace1, Y. Boteon1, V. Ronca1, D. Osei-Bordom1, Y. Oo1, H. Mergental2, D. Mirza2, S. Afford1

    1Centre for Liver and Gastroenterology Research, University of Birmingham, Birmingham, United Kingdom, 2Liver Surgery Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom

    *Purpose: Ex situ donor liver machine perfusion is developing into a promising tool to test organ viability prior to transplantation and vehicle to assess novel…
  • 2020 American Transplant Congress

    The Scenario of Delayed Graft Function in Brazil

    T. V. Sandes-Freitas1, M. Mazzali2, R. Manfro3, H. Tedesco-Silva4, L. Andrade5, V. Garcia6, E. Davi-Neto7, R. Esmeraldo8, C. Oliveira9, E. Lasmar10, R. Madeira11, G. Ferreira12, G. Meira13, F. Cavalcanti14, A. Bignelli15, D. Carvalho16, D. Pedroso17, L. Deboni18, A. Silva e Filho19, A. Vicari3, M. Sousa2, .. on behalf of 'DGF multicêntrico' group20

    1Department of Clinical Medicine, Universidade Federal do Ceará, Fortaleza, Brazil, 2HC/UNICAMP, Campinas, Brazil, 3HCPA/UFRGS, Porto Alegre, Brazil, 4Hospital do Rim, São Paulo, Brazil, 5HC-Botucatu/UNESP, Botucatu, Brazil, 6Santa Casa de Porto Alegre, Porto Alegre, Brazil, 7HC/FMUSP, São Paulo, Brazil, 8H. Geral de Fortaleza, Fortaleza, Brazil, 9HUWC/UFC, Fortaleza, Brazil, 10H. Universitário São José, Belo Horizonte, Brazil, 11H. Felício Rocho, Belo Horizonte, Brazil, 12Santa Casa de Juiz de Fora, Juiz de Fora, Brazil, 13Santa Casa de Montes Claros, Montes Claros, Brazil, 14Real Hospital Português, Recife, Brazil, 15H. Universitário Cajuru, Curitiba, Brazil, 16H. São Francisco na Providencia de Deus, Rio de Janeiro, Brazil, 17H. Santa Isabel, Blumenau, Brazil, 18H. Municipal São José, Joinville, Brazil, 19H. Israelita Albert Einstein, São Paulo, Brazil, 20ABTO, São Paulo, Brazil

    *Purpose: Unicenter Brazilian studies reported high incidences (50-70%) of delayed graft function (DGF). This is a multicenter Brazilian study aimed to evaluate the incidence, the…
  • 2020 American Transplant Congress

    The Association between Donor Hypothermia and Allograft Outcomes in Liver and Kidney Transplantation

    S. Karhadkar, B. Kaplunov, A. Di Carlo

    Temple University School of Medicine, Philadelphia, PA

    *Purpose: Traumatic brain injury patients benefit from mild to moderate hypothermia (32-35 °C); and in patients with cardiac arrest, stroke, and asphyxia, hypothermia is and…
  • 2020 American Transplant Congress

    Inequitable Access to Living Donor Kidney Transplantation in Black and Asian Minority Ethnic Groups in the UK: A Single Centre Cross-Sectional Cohort Study

    A. Cronin, K. Sran, R. Gokmen, A. Copley, L. Silas, R. Zakri

    Guy's and St. Thomas' Hospital, London, United Kingdom

    *Purpose: Black, Asian and Minority Ethnic (BAME) communities constitute 11% of the UK population, yet represent 31% of the national kidney transplant waiting list. Moreover,…
  • 2020 American Transplant Congress

    The Clinical Impact of HCV D+/r- Kidney Transplantation

    S. Meade1, M. A. Simpson2, E. D. Walshe2, M. E. Akoad2, F. D. Gordon2

    1Lahey Clinic, Burlington, MA, 2Transplantation, Lahey Clinic, Burlington, MA

    *Purpose: Transplantation of hepatitis C (HCV) positive organs into HCV negative recipients raises concerns regarding potential for infections unresponsive to DAAs. In September 2018, we…
  • 2020 American Transplant Congress

    Natural History of Tacrolimus Intrapatient Variability During the First Post-Transplant Year

    A. D. Leino, J. L. Rodgers, K. M. Abuls

    The Ohio State University Wexner Medical Center, Columbus, OH

    *Purpose: High tacrolimus intrapatient variability (IPV) is associated with inferior outcomes in solid organ transplantation. Many evaluations of IPV empirically exclude the early post-transplant period…
  • 2020 American Transplant Congress

    Pre-Transplant Pharmacogenetics Identifies CYP3A4 and CYP3A5 Heterogeneity among Caucasian Kidney Transplant Recipients

    N. Oliver1, L. Lindberg1, S. LeCorchick1, D. Morris1, S. Anand1, T. Srinivas2

    1Intermountain Medical Center, Murray, UT, 2University Hospitals Cleveland Medical Center, Cleveland, OH

    *Purpose: Tacrolimus has always been dosed based on therapeutic drug monitoring, however pharmacogenomics is becoming increasingly more utilized in the era of precision based medicine…
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