Abstracts Archive - Page 427 of 1683 - ATC Abstracts

2020 American Transplant Congress
Association between Education and Waitlist Mortality, Access to Transplant, and Post-Transplant Survival among Patients with Alcohol-Associated Liver Disease
A. T. Strauss, J. Motter, D. Segev, A. Massie, T. Purnell, J. Hamilton, A. Gurakar, A. Cameron, J. Garonzik-Wang
Johns Hopkins University, Baltimore, MD
*Purpose: Alcohol-associated liver disease (ALD) is the leading indication for liver transplant (LT) and these patients have been shown to have worse outcomes compared to…
2020 American Transplant Congress
Developing a Patient Specific Search of Heart Transplant Programs: Feedback from Heart Transplant Candidates and Recipients
W. T. McKinney¹, M. J. Bruin², C. R. Schaffhausen¹, S. Chu², J. Synder³, C. M. Martin⁴, T. Alexy⁴, B. L. Kasiske⁵, A. K. Israni¹
¹Nephrology, Hennepin Healthcare Research Institute, Minneapolis, MN, ²College of Design, University of Minnesota, Minneapolis, MN, ³Hennepin Healthcare Research Institute, Minneapolis, MN, ⁴Cardiology Division, University of Minnesota Department of Medicine, Minneapolis, MN, ⁵Department of Medicine, Hennepin Healthcare, Minneapolis, MN
*Purpose: Patients seeking a heart transplant must contemplate numerous factors when making decisions regarding their care. Waitlist acceptance criteria, donor acceptance practices and outcomes often…
2020 American Transplant Congress
The Pro-Inflammatory Profile of Alcoholic Patients Increases Risk for Ischemia-Reperfusion Injury During Orthotopic Liver Transplantation
A. Q. Terry¹, R. A. Sosa¹, M. Rossetti¹, F. Li¹, J. Nevarez-Mejia¹, B. V. Naini¹, F. M. Kaldas², V. M. Groysberg¹, S. M. Younan², R. W. Busuttil², D. W. Gjertson¹, J. W. Kupiec-Weglinski³, E. F. Reed¹
¹Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, ²Department of Surgery, UCLA, Los Angeles, CA, ³Departments of Pathology and Laboratory Medicine and Surgery, UCLA, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) elicits cellular damage which triggers a pro-inflammatory immune response that can lower allograft survival in orthotopic liver transplant (OLT) patients. In…
2020 American Transplant Congress
Normothermic Ex Vivo Perfusion of Marginal Liver Grafts Rapidly Stimulates Release of Graft-Derived Exosomes and Markedly Decreases the Inflammatory Pathways Induced at Early Times after Transplant Reperfusion
K. E. Brown¹, K. S. Keslar¹, D. Margeta¹, Q. Liu², A. Simioni², L. Del Angel Diaz², W. M. Baldwin¹, R. L. Fairchild¹, C. Quintini²
¹Lerner Research Institute, Cleveland Clinic, Cleveland, OH, ²Transplant Center, Cleveland Clinic, Cleveland, OH
*Purpose: Normothermic ex vivo machine perfusion of liver grafts (EVLP) is emerging as a superior preservation technology to cold storage. Normothermic EVLP transforms a metabolically…
2020 American Transplant Congress
Bridging the Gap: Normothermic Perfusion of Discarded Livers Significantly Alleviates the Donor Shortage
S. Raigani, R. J. De Vries, C. Carroll, Y. Chen, D. C. Chang, K. Uygun, H. Yeh
Transplant Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: European studies have shown that discarded liver grafts can be successfully transplanted if they meet viability criteria during normothermic machine perfusion (NMP). The potential…
2020 American Transplant Congress
Successful Transplantation of Murine Hearts Preserved 24h Under Subzero Ischemia Using Novel Bio-Inspired Next Generation Cryoprotectants
B. Oh¹, A. Callegari², M. Kline², A. Childs², M. Iglesias Lozano¹, G. Brandacher¹, X. Wei²
¹Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA), Johns Hopkins University School of Medicine, Baltimore, MD, ²X-Therma Inc., Richmond, CA
*Purpose: Extension of the organ ischemia window is of paramount importance to prolong viability of transplantable organs and to improve overall outcomes. Transport using a…
2020 American Transplant Congress
Decision Support Needs for African American Kidney Transplant Candidates and Social Support Networks
W. T. McKinney¹, A. Hart¹, S. Kurschner², M. Bruin³, J. Zulema-Woodward⁴, M. Partin², R. Patzer⁵
¹Nephrology, Hennepin Healthcare Research Institute, Minneapolis, MN, ²Hennepin Healthcare, Minneapolis, MN, ³College of Design, University of Minnesota, Minneapolis, MN, ⁴Rollins School of Public Health, Emory University, Atlanta, GA, ⁵Department of Surgery, Emory University, Atlanta, GA
*Purpose: Decision support tools to improve racial disparities in access to kidney transplant need to be relevant and tailored to underserved racial groups.*Methods: We conducted…
2020 American Transplant Congress
Risk Factors for Acquisition of Carbapenem-Resistant Gram-Negative Bacteria among Adult Patients of Respiratory Tract within 90 Days after Lung Transplantation
W. Chen, L. Zhao, L. Guo, S. Du, C. Liang, M. Li, B. Cao, B. Lu, J. Chen, C. Wang
China-Japan Friendship Hospital, Beijing, China
*Purpose: Carbapenem-resistant Gram-negative bacteria (CR-GNB) such as Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa are challenges in the management of lung transplantation patients. We conducted…
2020 American Transplant Congress
Clazakizumab (Anti-IL-6) Induces Foxp3+ Tregs in Highly HLA Sensitized Patients Desensitized for HLAi Transplantation (NCT03380962)
S. C. Jordan, S. Ge, N. Ammerman, M. Toyoda, E. Huang, A. Peng, R. Najjar, S. Sethi, S. Williamson, C. Myers, K. Lim, J. Choi, A. Vo
Cedars Sinai Medical Ctr, West Hollywood, CA
*Purpose: Interleukin-6 is an important inflammatory cytokine. In addition, it acts as a growth factor for B-cells, plasma cells and Th17 cells, inhibiting FoxP3+ Treg…
2020 American Transplant Congress
ESRD Risk Prediction for Black vs. White Related Living Kidney Donors
J. Wainright¹, A. Robinson¹, A. Wilk¹, D. Klassen², W. Cherikh¹, L. Cartwright¹, D. Stewart¹
¹Research, UNOS, Richmond, VA, ²Chief Medical Officer, UNOS, Richmond, VA
*Purpose: We studied 25-year risk of post-donation ESRD in black (n=10,214) and white (n=45,700) first-degree related living kidney donors (RLKDs) who donated in the US…