Abstracts Archive - Page 42 of 1683 - ATC Abstracts

2022 American Transplant Congress
Cold Ischemia Time is More Critical for Older Donor Kidney Survival: A Machine Learning Approach
J. Kim, J. Ahn, A. Massie, D. Segev, S. Bae
Johns Hopkins, Baltimore, MD
*Purpose: Increasing utilization of kidneys from older donors is a potential solution to mitigate the organ shortage. However, older donor age is a risk factor…
2022 American Transplant Congress
ESRD is Increasing Faster After Living Kidney Donation Than it Does in the Unselected US Population: A New Risk Metric?
R. W. Steiner
UCSD School of Medicine, San Diego, San Diego, CA
*Purpose: ESRD rates increase exponentially both after kidney donation and as the US population ages. Increases in ESRD rates from the first to the second…
2022 American Transplant Congress
Superoxide in Cardiac Allografts from Donors After Circulatory Death
M. Urban¹, T. Bruett², K. F. Duncan¹, N. W. Markin³, M. M. Chacon³, M. C. Zimmerman⁴
¹Department of Surgery. Division of Cardiothoracic Surgery, University of Nebraska Medical Center, Omaha, NE, ²College of Medicine. Department of Cellular and Integtrative Physiology., University of Nebraska Medical Center, Omaha, NE, ³Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE
*Purpose: Quality of cardiac allografts from donors after circulatory death (DCD) is adversely impacted by warm ischemia and subsequent reperfusion during organ resuscitation. Post-transplant myocardial…
2022 American Transplant Congress
Association Between Histopathological Features on Implantation Renal Biopsies and Graft Outcomes and Kdpi
C. Khor, S. McGinn, C. Fisher, R. Yang, K. Richards, K. Muir, J. Lu
Nephrology, Royal North Shore Hospital, Sydney, Australia
*Purpose: The global shortage of organs and the increasing use of marginal kidneys for transplantation necessitates an accurate assessment of deceased donor kidneys. The kidney…
2022 American Transplant Congress
Donor and Recipient Age Matching for Kidney Transplantation: A Machine Learning Approach
J. Kim, J. Ahn, A. Massie, D. Segev, S. Bae
Johns Hopkins, Baltimore, MD
*Purpose: Under the concept of ‘longevity matching,’ the Kidney Allocation System favors matching younger deceased donors with younger kidney transplant (KT) candidates. However, it remains…
2022 American Transplant Congress
Additional Dose of SARS-CoV-2 Vaccine Increases Neutralization Capacity in Solid Organ Transplant Recipients
Y. Yoo¹, J. Husson², T. Iraguha³, S. Niederhaus⁴, X. Wen⁵, A. Crane⁵, A. Carrier⁵, J. Avruch⁵, A. Ahuja⁶, M. Mathew⁷, S. Dahiya⁸, A. P. Rapoport⁸, D. Atanackovic⁸, K. K. Saharia²
¹Inst of Human Virology, Baltimore, MD, ²Div of Infect Diseases, Univ of Maryland School of Med. and Inst of Human Virology, Baltimore, MD, ³Univ of Maryland School of Med. and Greenebaum Comprehensive Cancer Center, Baltimore, MD, ⁴Dept of Surgery, Univ of Maryland School of Med., Baltimore, MD, ⁵Dept of Surgery, Univ of Maryland Med. Center, Baltimore, MD, ⁶Dept of Medicine, Univ of Maryland Med. Center, Baltimore, MD, ⁷Div of Infect. Diseases, Univ of Maryland Med. Center, Baltimore, MD, ⁸Dept of Medicine, Univ of Maryland School of Med. and Greenebaum Comprehensive Cancer Center, Baltimore, MD
*Purpose: Solid organ transplant recipients (SOTR) develop weak antibody responses after SARS-CoV-2 vaccination. Published data on neutralizing activity of plasma, a better measure of protection,…
2022 American Transplant Congress
Impact of Donor-to-Recipient Body Surface Area Ratio on Graft Survival and Mortality Following Deceased Donor Liver Transplants
S. Radomski, L. Zeiser, A. Massie, S. Ottmann, D. Segev, E. King
Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: The impact of size mismatch on graft survival in living donor liver transplant is well established but is not a common concern in deceased…
2022 American Transplant Congress
Leveraging Single-Cell Signatures in Kidney Transplant Biopsies Uncovers Immunological Heterogeneity Within Rejection Phenotypes
J. Callemeyn¹, B. Lamarthée¹, P. Koshy², T. Debyser³, E. Van Loon¹, A. Franken⁴, T. Van Brussel⁴, I. Arijs⁴, D. Lambrechts⁴, M. Rabant⁵, A. Senev¹, T. Vaulet⁶, C. Tinel¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium, ³Faculty of Medicine, KU Leuven, Leuven, Belgium, ⁴Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, ⁵Necker-Enfants Malades Institute, Institut national de la santé et de la recherche médicale (Inserm), Université de Paris, Paris, France, ⁶ESAT Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium
*Purpose: Rejection of the kidney allograft is hallmarked by the accumulation of inflammatory cells within the renal architecture, leading to microvascular or tubulointerstitial inflammation. However,…
2022 American Transplant Congress
Axl and MerTK Regulate the Activation of Liver Ischemia Reperfusion Injury by Upregulating Il-13 in Kupffer Cells
J. Zhang¹, M. Ni¹, H. Zhang¹, R. Busuttil¹, J. Kupiec-Weglinski¹, X. Wang², J. Jin³, Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ³Guilin Medical University, Guilin, China
*Purpose: Ischemia reperfusion injury (IRI) remains an unresolved clinical problem. A sterile inflammatory response drives the disease pathogenesis. Although mechanisms of liver innate immune activation…
2022 American Transplant Congress
Bone Fractures Are Not Increased in Older Prior Living Kidney Donors
H. Amer¹, H. Maradit Kremers¹, D. Larson¹, I. Zaniletti¹, W. K. Kremers¹, A. Matas², B. Kasiske³, S. Khosla¹, R. Kumar¹
¹Mayo Clinic, Rochester, MN, ²University of Minnesota, Minneapolis, MN, ³Hennepin County Medical Center, Minneapolis, MN
*Purpose: Living kidney donors were shown to have derangements of bone biomarkers resembling those occurring in early chronic kidney disease within 36 months of donation.…