Abstracts Archive - Page 398 of 1683 - ATC Abstracts

2020 American Transplant Congress
A Recombinant, Fully Human ATG Polyclonal Antibody Drug Drives Immune Cell Depletion in a Model of Graft-versus-Host Disease
S. M. Keating, A. S. Adler, R. A. Mizrahi, J. Leong, M. A. Asensio, Y. W. Lim, A. R. Niedecken, Y. Chiang, R. Leong, D. S. Johnson
Immunology, GigaGen, South San Francisco, CA
*Purpose: Anti-thymocyte globulin (ATGs) are polyclonal antibody products that target and deplete T cells for immunosuppression in transplantation (prophylaxis of rejection). Since ATGs are derived…
2020 American Transplant Congress
Depletional Profiles of Human and Rhesus Specific Anti-Thymocyte Globulins in Rhesus Macaques
B. I. Shaw¹, R. Schmitz¹, D. M. Magnani², F. Leopardi¹, A. D. Kirk¹
¹Surgery, Duke University, Durham, NC, ²Medicine, MassBiologics of the University of Massachusetts Medical School, Boston, MA
*Purpose: Rabbit anti-human ATG (rATG; Thymoglobulin®) is the most commonly used formulation for depletional induction therapy in the United States. However, given that it is…
2020 American Transplant Congress
Altering Homeostatic Repopulation with Thymic Irradiation and Donor Mesenchymal Stem Cell Infusions in a Nonhuman Primate Model
R. Schmitz, M. S. Mulvihill, Z. W. Fitch, T. How, F. Leopardi, A. D. Kirk
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Lymphocyte depletion and subsequent homeostatic repopulation present opportunities to shape the alloreactive immune repertoire to favor tolerance. We tested if the addition of thymic…
2020 American Transplant Congress
Granulocyte-Colony Stimulating Factor (G-CSF) and Granulocyte-Macrophage CSF (GM-CSF) Administration Enriches for Highly Suppressive CD4⁺CD45RA^–Foxp3^hi Cells in Leukapheresis Products of Rhesus Monkeys
K. Sasaki, Y. Wang, L. Lu, J. Hughes, V. Vujevich, A. W. Thomson, M. B. Ezzelarab
Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: In humans, CD4+CD45RA-Foxp3hi T cells comprise a regulatory T cell (Treg) subset with highly suppressive function. We have previously shown that granulocyte-colony stimulating factor…
2020 American Transplant Congress
Acute on Chronic Liver Failure (ACLF) Patients Have a Dynamic and Progressive Clinical Course Until Receiving a Liver Transplant: A 5-Year Study at the National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico
E. Cervantes-Alvarez¹, M. J. Lizardo-Thiebaud¹, E. Alatorre-Arenas¹, O. Mendez-Guerrero¹, S. Yarza-Regalado¹, A. Torre¹, M. Vilatobá², D. Kershenobich¹, C. A. Huang³, N. Navarro-Alvarez¹
¹Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ³Surgery, University of Colorado Anschutz Medical Campus, DENVER, CO
*Purpose: To characterize the clinical course of patients diagnosed with acute on chronic liver failure (ACLF) before undergoing liver transplantation. ACLF is characterized by an…
2020 American Transplant Congress
Single Center Snapshot Experience of dd-cfDNA in Lung Transplantation
D. Levine, P. Ong, D. De Armond, E. Sako
University of Texas Health San Antonio, San Antonio, TX
*Purpose: Chronic lung allograft dysfunction (CLAD) is the primary etiology of graft failure and associated with poor survival post lung transplantation (LT). Risk factors for…
2020 American Transplant Congress
Clinical Outcomes in Kidney Transplant Recipients Following Implementation of a Strategic Maintenance Reduction Protocol
H. Perkins, K. Foster, N. Patel, H. Meadows, F. Bartlett, C. Perez, J. McGillicuddy, N. Pilch, M. Casey, M. A. Posadas-Salas, D. Taber
Pharmacy, Medical University of South Carolina, Charleston, SC
*Purpose: Post-transplant complications are commonly due to over-immunosuppression, particularly as it relates to infections. The purpose of this study was to assess clinical outcomes in…
2020 American Transplant Congress
Protective Effect of Fucoidan Against Tacrolimus-Induced Nephrotoxicity in LLC-PK1 Cells
H. J. Jang
Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of
*Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…
2020 American Transplant Congress
Src Induces Endothelial-to-Mesenchymal Transition and Renal Allograft Fibrosis via Promoting WNT/β-catenin Pathway
W. Zijie, Z. Gui, M. Zheng, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu
Jiangsu Province Hospital, Nanjing, China
*Purpose: Endothelial-to-mesenchymal(EndMT)is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial fibrosis in our previous studies. Increased proto-oncogene tyrosine-protein kinase…
2020 American Transplant Congress
Targeting CD62 – CD162 Signaling with a Soluble Form of a Tandem-PSGL-1 in a Murine Model of Hindlimb Transplantation
K. Kadono¹, F. Messner², Y. Guo², B. Oh², G. Brandacher², J. W. Kupiec-Weglinski¹
¹Liver Transplant Surgery, UCLA, Los Angeles, CA, ²Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Static cold storage (SCS) times for organs and tissues are currently limited to hours. Once outside the body, tissues lack oxygen and nutrient supply…