Abstracts Archive - Page 395 of 1683 - ATC Abstracts

2020 American Transplant Congress
First Report of Successful CD38-Antagonist Daratumumab Augmented Carfilzomib-Based Treatment of Refractory Definite AMR of the Lung Allograft
M. N. Kildea¹, C. R. Ensor¹, J. Kim¹, L. Bogar¹, D. Colella¹, R. D. Davis¹, M. Marschner¹, A. Zeevi², N. Soe¹, C. Gries¹
¹AdventHealth, Orlando, FL, ²University of Pittsburgh, Pittsburgh, PA
*Purpose: Antibody-mediated rejection (AMR) after lung transplant (LT) is associated with early progressive chronic lung allograft dysfunction (CLAD) and death. Therapeutic regimens remain poorly evaluated.…
2020 American Transplant Congress
The Ratio between Naïve and Memory B Cells is Associated with Development of Early Donor-Specific Antibodies within the First Month after Lung Transplantation
A. Hitz¹, R. Bellmàs Sanz¹, F. Ius², J. Kühne¹, B. Wiegmann², W. Sommer², J. Salman², T. Siemeni², C. Kühn², M. Avsar², A. Haverich², I. Tudorache², G. Warnecke², C. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany
*Purpose: After lung transplantation (LuTx), the development of early donor HLA-specific antibodies (eDSA) has been shown to be associated with antibody-mediated rejection (AMR) and poor…
2020 American Transplant Congress
Single Center Snapshot Experience of dd-cfDNA in Lung Transplantation
D. Levine, P. Ong, D. De Armond, E. Sako
University of Texas Health San Antonio, San Antonio, TX
*Purpose: Chronic lung allograft dysfunction (CLAD) is the primary etiology of graft failure and associated with poor survival post lung transplantation (LT). Risk factors for…
2020 American Transplant Congress
Outcomes of a Pre-Transplant Desensitization Protocol with Carfilzomib, Plasmapheresis, and IVIG for Broadly Sensitized Lung Transplant Candidates: A Case Series
S. Fredrick¹, C. Iasella², C. Moore¹, M. Mangiola³, Q. Xu³, C. Ensor⁴, D. Riciutti², C. LaFratte², P. Sanchez³, M. Morrell³, J. McDyer³, A. Zeevi³
¹Department of Pharmacy, UPMC Presbyterian, Pittsburgh, PA, ²University of Pittsburgh School of Pharmacy, Pittsburgh, PA, ³University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Department of Pharmacy, AdventHealth, Orlando, FL
*Purpose: The presence of anti-human leukocyte antigen (HLA) antibodies in lung transplant candidates leads to increased wait list times and antibody-mediated rejection (AMR) post-transplant. We…
2020 American Transplant Congress
Evaluation of Bronchial Artery Revascularization in Lung Transplantation: A Systematic Review and Meta-Analysis
T. J. O'Malley¹, A. M. Jordan¹, E. J. Maynes¹, A. Saxena¹, K. W. Prochno¹, T. K. Rajab², H. T. Massey¹, R. C. Daly³, V. Tchantchaleishvili¹
¹Division of Cardiac Surgery, Thomas Jefferson University, Philadelphia, PA, ²University of Colorado, Aurora, CO, ³Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN
*Purpose: Bronchial artery revascularization (BAR) during lung transplantation has been hypothesized to improve early tracheal healing and delay the onset of bronchiolitis obliterans. We evaluated…
2020 American Transplant Congress
Survival with Post-Transplant Diabetes Mellitus is Worse after Heart Transplantation
K. Y. Feng¹, E. Henricksen², Y. Moayedi³, R. Lee², J. Han¹, S. Purewal¹, A. Puing¹, M. Basina¹, J. J. Teuteberg¹, K. K. Khush¹
¹Medicine, Stanford University, Palo Alto, CA, ²Pharmacy, Stanford University, Palo Alto, CA, ³Cardiology, University Health Network, Toronto, ON, Canada
*Purpose: An increasing number of patients undergoing heart transplantation (HTx) have diabetes mellitus (DM). However, there is limited data on clinical outcomes after HTx in…
2020 American Transplant Congress
Chronic Hyperammonemia an Important Cause of Morbidity in Isolated Intestine Transplant Patients with Venous Outflow to the Vena Cava
R. S. Mangus, C. A. Kubal, T. Burch, B. Ekser, P. Mihaylov, J. Fridell
Indiana University, Indianapolis, IN
*Purpose: There are limited options for superior mesenteric vein (SMV) outflow in isolated intestine transplant (ITx), the two most common being anastomosis to the recipient…
2020 American Transplant Congress
Glucocorticoid-Induced Osteoporosis in Lung Transplant Patients
J. Clark, L. Potter
Department of Pharmacy, University of Chicago Medicine, Chicago, IL
*Purpose: Although vital for preventing rejection, glucocorticoids contribute to post-operative morbidity, including osteoporosis. The primary purpose of this study was to identify the occurrence of…
2020 American Transplant Congress
Vascular Complications in Pediatric Intestine Transplant Recipients – Treatment Strategies and Outcomes
A. Amin, Y. Chang, B. Emmanuel, A. Ganoza, G. Bond, A. Khanna, K. Soltys, R. Sindhi, G. Mazariegos
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: To identify vascular complications in pediatric intestine transplant (IT) recipients, evaluate treatment strategies, and review their impact on graft loss and patient mortality.*Methods: Retrospective…
2020 American Transplant Congress
Megacystis Microcolon Intestinal Hypoperistalsis Syndrome: A Case Series with Long Term Follow Up and Prolonged Survival
K. M. Prathapan¹, V. Raghu¹, A. Ganoza², K. Ackerman¹, T. Presel¹, J. A. Yaworski¹, W. Sevilla¹, D. King¹, J. Rudolph¹, F. Alissa¹
¹Division of Pediatric Gastroenterology, Hepatology and Nutrition, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, ²Hillman Center for Pediatric Transplantation, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA
*Purpose: To describe clinical characteristics, management and survival in a cohort of Megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) patients.*Methods: We conducted a retrospective chart review of MMIHS…