Abstracts Archive - Page 380 of 1683 - ATC Abstracts

2020 American Transplant Congress
Specific Gut Microbiota Community Suppresses Acute Rejection by Reducing Natural Killer Cell Population
W. Zhang, L. Gong, Y. Xu, X. Hu
Department of Urology, Capital Medical University Beijing Chaoyang Hospital, Urology Institute of Capital Medical University, Beijing, China
*Purpose: The gut microbiota community was reported to be altered by high-dose FK506 treatment, while fecal microbiota transplantation with such microbiota plus low-dose FK506 could…
2020 American Transplant Congress
Single Cell RNA Sequencing of Murine Kidney Allografts Identifies Macrophage Gene Signature Associated with Acute Rejection
A. Dangi¹, N. Natesh², M. Monal¹, J. Wang³, X. Shen², X. Luo¹
¹Nephrology/Medicine, Duke University, Durham, NC, ²Biomedical Engineering, Duke University, Durham, NC, ³Surgery, Duke University, Durham, NC
*Purpose: Evaluating kidney allografts using single cell RNA sequencing (scRNAseq) can provide a comprehensive qualitative and quantitative gene expression data on thousands of individual cells.…
2020 American Transplant Congress
Assessment of the Usefulness of Urine Signature to Differentiate Acute Rejection in a Prospective Kidney Transplantation Cohort
J. Seo¹, S. Jung², J. Moon², K. Jeong³, C. Kim⁴, B. Chung⁵, J. Park⁶, Y. Kim⁷, S. Lee²
¹Department of Core Research Laboratory, Medical Science Institute, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ²Department of Internal Medicine, Division of Nephrology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ³Department of Internal Medicine, Division of Nephrology, College of Medicine, Kyung Hee University, Seoul, Korea, Republic of, ⁴Department of Internal Medicine, Division of Nephrology, Kyung-pook National University School of Medicine, Daegu, Korea, Republic of, ⁵Department of Internal Medicine, Division of Nephrology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ⁶Department of Internal Medicine, Sungkyunkwan University, Samsung Hospital, College of Medicine, Seoul, Korea, Republic of, ⁷Department of Internal Medicine, Division of Nephrology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea, Republic of
*Purpose: Despite many biomarker studies in the field of transplantation, development and validation of noninvasive molecular assays to diagnose disease and monitor immune activity is…
2020 American Transplant Congress
Human Antigen R (HuR): A New Regulator of Heme Oxygenase-1 Cytoprotection in Mouse and Human Liver Transplantation
K. J. Dery¹, K. Nakamura², K. Kadono¹, H. Hirao¹, S. Kageyama¹, T. Ito¹, H. Kojima¹, F. Kaldas¹, R. W. Busuttil¹, J. W. Kupiec-Weglinski¹
¹Department of Surgery, Division of Liver and Pancreas Transplantation, UCLA, Los Angeles, CA, ²Surgery, Nishi-Kobe Medical Center, Hyogo, Japan
*Purpose: Ischemia-reperfusion injury (IRI) represents a risk factor in liver transplantation (LT). We have shown that overexpression of heme oxygenase 1 (HO-1) mitigates hepatic IRI…
2020 American Transplant Congress
Metabolism Reprogramming During Conventional versus Ischemia-Free Liver Transplantation
Z. Guo¹, Z. Zhang¹, N. Gao¹, H. Zhang², X. He¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Sun Yat-sen University, Guangzhou, China
*Purpose: Our group has developed a novel transplant procedure called ischemia-free liver transplantation (IFLT), during which the liver can be procured, preserved and implanted without…
2020 American Transplant Congress
TGR5/Cathepsin E Signaling Regulates Macrophage Innate Immune Activation in the Sterile Inflammatory Liver Injury
H. Zhou, S. Zhou, Q. Wang, Z. Rao, X. Wang, L. Lu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: The hepatic proinflammatory response represents a major cause of liver ischemia and reperfusion (IR) injury. Although the role of plasma membrane-bound G protein-coupled bile…
2020 American Transplant Congress
The Art Rather Than the Science of Non-HLA Antibody Mediated Rejection in Heart Transplantation: A Single Center Experience
A. Alam, S. Mckean, R. Patel, V. Darst, H. Zafar, C. Guerrero, M. Askar, T. Sam, S. Hall
Cardiology, Baylor University Medical Center, Dallas, TX
*Purpose: The role of non-HLA antibodies (Ab) in HLA-DSA negative antibody mediated rejection (AMR) following heart transplant (HTx) remains largely unknown.*Methods: Retrospective analysis of all…
2020 American Transplant Congress
Impact of the 2015 LAS Revisions on Lung Candidates with Pulmonary Vascular Disease
K. Lindblad¹, R. Goff¹, K. Chan²
¹UNOS, Richmond, VA, ²University of Michigan, Ann Arbor, MI
*Purpose: On February 19, 2015 a major revision to the Lung Allocation Score (LAS) was implemented with the goal of more accurately reflecting waitlist urgency…
2020 American Transplant Congress
Lacripep^TM and its Analogs Act as Novel Interventional Agents to Promote Long-Term Islet Transplantation Outcomes
M. Ma¹, K. Teixeira², G. Laurie², K. Brayman¹, P. Chhabra¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Cell Biology, University of Virginia Health System, Charlottesville, VA
*Purpose: To study the prosecretory, prosurvival, and mitogenic effect of Lacripep™ and its analogs in enhancing islet viability, increasing insulin secretion and promoting long-term islet…
2020 American Transplant Congress
Mir-124/ire-1α Affects Renal Ischemia/Reperfusion Injury by Regulating Endoplasmic Reticulum Stress in Renal Tubularepithelial Cells
C. Ding, W. Xue
Department of Renal Transplantation, The First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
*Purpose: In this study, we investigated the protective functions of miR-124 on renal I/R injury both in vivo and in vitro and explored its underlying…