Abstracts Archive - Page 353 of 1683 - ATC Abstracts

2020 American Transplant Congress
Withaferin A Prolongs Islet Allograft Survival in a Mouse Transplant Model by Preventing T Lymphocyte Proliferation and Dendritic Cell Maturation
K. Kumano¹, M. A. Kanak², S. Vasu¹, Y. Liu¹, M. Lawrence¹, B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Virginial Commonwealth University Medical Center, Richmond, VA
*Purpose: Chronic decline in islet graft function and toxicities imposed by immunosuppressant drugs remain as challenges to the widespread use of islet transplantation for type…
2020 American Transplant Congress
Lacripep^TM and its Analogs Act as Novel Interventional Agents to Promote Long-Term Islet Transplantation Outcomes
M. Ma¹, K. Teixeira², G. Laurie², K. Brayman¹, P. Chhabra¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Cell Biology, University of Virginia Health System, Charlottesville, VA
*Purpose: To study the prosecretory, prosurvival, and mitogenic effect of Lacripep™ and its analogs in enhancing islet viability, increasing insulin secretion and promoting long-term islet…
2020 American Transplant Congress
Specific Gut Microbiota Community Suppresses Acute Rejection by Reducing Natural Killer Cell Population
W. Zhang, L. Gong, Y. Xu, X. Hu
Department of Urology, Capital Medical University Beijing Chaoyang Hospital, Urology Institute of Capital Medical University, Beijing, China
*Purpose: The gut microbiota community was reported to be altered by high-dose FK506 treatment, while fecal microbiota transplantation with such microbiota plus low-dose FK506 could…
2020 American Transplant Congress
Cyclophilin-D Inhibition Mitigates Cardiac Allograft Ischemia-Reperfusion Injury and Rejection
A. Qamar¹, P. McLeod², J. Jiang², X. Huang², A. M. Jevnikar², Z. Zhang²
¹Pathology & Laboratory Medicine, University of Western Ontario, London, ON, Canada, ²London Health Sciences Center, London, ON, Canada
*Purpose: The clinical relevance of ischemia-reperfusion injury (IRI) in the context of organ transplantation is well-established. IRI is associated with various forms of programmed cell…
2020 American Transplant Congress
XIAP Enhances Xenoislet Survival: Novel Models to Evaluate Pretransplantation Gene Modifications
G. R. Devi¹, Z. Fitch¹, M. Song¹, M. Ribeiro¹, A. McGowan¹, X. Luo², B. H. Collins¹, A. D. Kirk¹
¹Department of Surgery, Duke Univesity School of Medicine, Durham, NC, ²Division of Nephrology, Duke Univesity School of Medicine, Durham, NC
*Purpose: Porcine islet xenotransplantation offers a reliable and near limitless supply of islets for the treatment of type 1 diabetes. Intraportal infusion of cells exposes…
2020 American Transplant Congress
Ex Vivo Normothermic Perfusion Improves Cold Ischemic Injury and DGF in an Experimental Model of DBD Kidney Transplantation
A. Gutierrez-Dalmau¹, V. Alastrue², Á. García De Jalon³, M. Sánchez³, C. Del Agua⁴, V. P. González⁵, Á. Roncales³, J. Gómez-Arrue⁶, C. Pastor⁶, B. Sáez⁷, L. M. Esteban⁸, M. J. Gil³, M. Doblaré⁹, Á. Borque-Fernando³
¹Nephrology, Hospital Universitario Miguel Servet (HUMS), IIS Aragón, Zaragoza, Spain, ²EBERS, Zaragoza, Spain, ³Urology, HUMS, Zaragoza, Spain, ⁴Pathology, HUMS, Zaragoza, Spain, ⁵Hematology, HUMS, Zaragoza, Spain, ⁶Experimental Surgery, IACS, Zaragoza, Spain, ⁷Faculty of Health Sciences, San Jorge University, Zaragoza, Spain, ⁸EUPLA, Zaragoza University, Zaragoza, Spain, ⁹Department of Mechanical Engineering, Zaragoza University, Zaragoza, Spain
*Purpose: Cold ischemic (CI) injury results in high rates of DGF, reduced graft function and survival. Ex vivo normothermic perfusion (EVNP) has shown to improve…
2020 American Transplant Congress
Lung Mucosal Biopsies Deteriorate with Time Post-Transplant: A Molecular Analysis
M. D. Parkes¹, P. Halloran¹, K. Halloran², &. the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: Mucosal biopsies from the third airway bifurcation (3BMBs) assessed molecularly can be used to detect rejection (DOI: 10.1111/ajt.15685), and may also provide insights into…
2020 American Transplant Congress
Tetramethylpyrazine Activated Pparγ in Resuscitating the Liver Graft Donatedafter Cardiac Death
F. Zhen, F. Lin, Z. Lihua, L. Wenjin, X. Yan, C. Yong, Y. Qifa
Zhongnan Hospital of Wuhan University, Wuhan, China
*Purpose: to identify whether Tetramethylpyrazine (TMP) pretreatment can protect DCD grafts preserved during cold storage or/and HMP and transplanted.The protective mechanisms of TMP were also…
2020 American Transplant Congress
Estrogen Receptor Beta Deletion in the Vascular Endothelium is Protective in Renal Ischemia Reperfusion Injury
L. Krumeich¹, P. Hernandez¹, C. O'Brien¹, S. Concors¹, Z. Wang¹, G. Ge¹, W. Hancock², M. Levine¹
¹Hospital of University of Pennsylvania, Philadelphia, PA, ²Childrens Hospital of Philadelphia, Philadelphia, PA
*Purpose: Renal ischemia reperfusion injury (IRI) is a major contributor to early allograft dysfunction (EAD) in kidney transplantation. We previously identified lower rates of EAD…
2020 American Transplant Congress
Simultaneous Pancreas-Kidney Transplant: – The Effects of Early Steroid Withdrawal, Donor and Recipient Variables on Patient Survival
D. Kloda¹, M. McLeod², M. Romine¹, J. Ladowski², J. Locke¹, C. Young¹
¹Department of Surgery - Division of Transplantation, University of Alabama, Birmingham, AL, ²Department of Surgery, University of Alabama, Birmingham, AL
*Purpose: Simultaneous pancreas-kidney transplantation (SPK) improves survival in type I diabetic patients with end stage renal disease (ESRD). Corticosteroids have traditionally been an integral component…