Abstracts Archive - Page 326 of 1683 - ATC Abstracts

2021 American Transplant Congress
Role of Trugraf Testing in Kidney Allografts Previously Biopsied for Dysfunction
Y. A. Qazi¹, W. Mon¹, C. Choi¹, S. Qazi², M. Smogorzewski¹
¹Keck Medical Center at USC, Los Angeles, CA, ²Keck Medical Center at USC, La Canada Flt, CA
*Purpose: TruGraf®, can be used as an alternative to surveillance biopsies for ruling out “silent” subclinical acute rejections in transplant patients with stable graft function.…
2021 American Transplant Congress
Core Signature of Rejection-Specific Cytokines and Chemokines in Heart Biopsies After Transplantation
L. M. Radomsky¹, Y. Scheibner², J. F. Kuehne¹, J. Keil¹, K. Beushausen¹, K. Ludmilla², A. Schick², F. Ius², G. Warnecke³, C. Bara², C. S. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ³Clinic for Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
*Purpose: Allograft rejection remains one of the limiting factors for survival after HTX. The aim of this project was to characterize the cytokine/chemokine network in…
2021 American Transplant Congress
The Role of the B2 Microglobulin Trend in Patients with Delayed Graft Function After Kidney Transplant
A. Perez-Gutierrez, P. J. Bachul, B. Juengel, P. Witkowski, D. DiSabato, R. Barth, J. Fung, Y. Becker
Surgery, University of Chicago, Chicago, IL
*Purpose: Delayed graft function (DGF) is associated with worse short and long-term outcomes after kidney transplantation. There is a lack of biomarkers to predict outcomes…
2021 American Transplant Congress
Brain Natriuretic Peptide and Pedometer Activity are Most Predictive of Poor Kidney Transplant Waitlist Outcomes
P. Manay¹, P. TenEyck², R. Kalil³, M. Sanders⁴, M. Swee⁴, G. Binns⁵, J. Hornikel⁵, D. Katz¹
¹Department of Surgery, University of Iowa, Iowa City, IA, ²Institute for Clinical and Translational Science, University of Iowa, Iowa City, IA, ³Department of Medicine, University of Maryland Medical Center, Baltimore, MD, ⁴Department of Medicine, University of Iowa, Iowa City, IA, ⁵Iowa City VAMC, Iowa City, IA
*Purpose: Tools for indicating which patients are most at risk for complications and death after transplant listing would allow for a rational approach to targeted…
2021 American Transplant Congress
Real-time Donor-derived Cell-free Dna Kinetics Indicate Decreased “Molecular Injury” During Treatment of Acute Renal Allograft Rejection
R. Hinojosa¹, K. M. Hitchman², D. J. Ross³, R. C. Hall¹, J. E. Nelson¹, E. L. Kincaide¹, K. Klein¹, A. M. Bell³
¹Pharmacotherapy Education and Research Center | Long School of Medicine, UT Health San Antonio | University Transplant Center, University Health, San Antonio, TX, ²Long School of Medicine, UT Health San Antonio | University Transplant Center, University Health, San Antonio, TX, ³CareDx, Inc., Brisbane, CA
*Purpose: Dd-cfDNA is a validated plasma analyte (t½~30 min) for surveillance of renal transplant (KT) rejection with limited reports characterizing response to acute allograft rejection…
2021 American Transplant Congress
Inhibition of Apoptosis During Ex Situ Liver Normothermic Machine Perfusion Decreases Reperfusion Injury and Improves Viability
S. Raigani¹, S. Baptista¹, A. Ohman², J. Santiago², I. Rosales¹, M. Heaney², J. Boylan², T. Coe¹, K. Uygun¹, J. Sanders², H. Yeh¹
¹Transplant Surgery, Massachusetts General Hospital, Boston, MA, ²Pediatric Endocrinology, Brown University, Providence, RI
*Purpose: Normothermic machine perfusion (NMP) is an ideal platform for delivery of novel therapeutics aimed at rehabilitation of discarded or marginal livers. We examined the…
2021 American Transplant Congress
Donor-Derived Cell-Free DNA Performance Characteristics are Similar for Repeat and Primary Kidney Transplant Recipients
V. R. Peddi¹, S. Akkina², S. C. Jordan³, W. Tian⁴, Y. Qazi⁵
¹California Pacific Medical Center, San Francisco, CA, ²Loyola University Medical Center, Maywood, IL, ³Cedars-Sinai Medical Center, Los Angeles, CA, ⁴CareDx, Brisbane, CA, ⁵University of Southern California, Los Angeles, CA
*Purpose: Repeat kidney transplants (RKT) represent 12.4% of kidney transplants (KT) (10.9% of all living donor and 13.6% of all deceased donor). Most RKT are…
2021 American Transplant Congress
Recipient and Kidney Allograft Outcomes from Hypertensive Live-Donor in the United States
S. Riad¹, S. Jackson², D. Vock³, A. Matas⁴
¹Medicine, University of Minnesota, Minneapolis, MN, ²Complex Care Analytics, M-Health Fairview, Minneapolis, MN, ³School of Public Health, University of Minnesota, Minneapolis, MN, ⁴Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Controlled hypertension in select prospective kidney donors is no longer an exclusion criterion for donation. We examined the association between pre-donation hypertension (HTN) and…
2021 American Transplant Congress
Sigma-1 Receptor Agonists are Renoprotective in Experimental Kidney Transplantation
A. Hosszu¹, T. Lakat¹, A. Toth¹, D. Balogh¹, J. Hodrea¹, L. J. Wagner², A. J. Szabo¹, A. Fekete¹
¹1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ²Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
*Purpose: Kidney transplantation (Tx) is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a…
2021 American Transplant Congress
Comparison of Next Generation Sequencing Donor-derived Cell Free DNA Assay Utilizing Whole Genome Sequencing
N. Singh¹, M. S. Naseer¹, D. Aultman², H. Shokouh-Amiri², G. Zibari²
¹Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, ²Advanced Surgery, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA
*Purpose: Circulating donor-derived cell free DNA (dd-cfDNA) is a non-invasive biomarker of kidney allograft injury with a high negative predictive value for ruling out acute…