Abstracts Archive - Page 326 of 1683 - ATC Abstracts

2021 American Transplant Congress
Donor Derived Cell Free Dna: Teasing Out the Optimal Threshold for Antibody Mediated Rejection
M. Mattu¹, H. Murad¹, M. Merzkani¹, A. Malone¹, R. Delos Santos¹, M. Wang², B. Wang², S. Chang², T. Alhamad¹
¹Department of Medicine, Washington University in St Louis, St Louis, MO, ²Washington University in St Louis, St Louis, MO
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) assay is a putative noninvasive marker for renal allograft rejection and other etiologies of injury such as BK nephropathy. The…
2021 American Transplant Congress
Segmental Susceptibility of Intestinal Stem Cells to Cold Storage Preservation Injury in a Porcine Model
E. K. Ludwig¹, N. Abraham², D. Sudan², A. Barbas², C. Schaaf¹, J. Freund¹, A. S. Stewart¹, B. Veerasammy¹, L. M. Gonzalez¹
¹North Carolina State University, Raleigh, NC, ²Duke University, Durham, NC
*Purpose: Cold storage (CS) is the current gold standard preservation method for small bowel (SB) prior to transplantation. However, CS can cause epithelial detachment, sloughing,…
2021 American Transplant Congress
Death Among Living Liver Donors- Are We Overestimating the Risk?
H. J. Braun, A. M. Shui, N. L. Ascher, J. P. Roberts
University of California, San Francisco, San Francisco, CA
*Purpose: In the United States, the estimated risk of death associated with live liver donation is currently quoted at 0.1% for left lobe donation, and…
2021 American Transplant Congress
Outcomes of Downstaging Hepatocellular Carcinoma (HCC) to within Milan Criteria Before Liver Transplantation (LT): A Multicenter Analysis of the “All-comers” Protocol
B. Natarajan¹, P. Tabrizian², M. Hoteit³, C. Frenette⁴, T. Ghaziani⁵, R. Dhanasekaran⁵, N. Parikh⁶, J. Guy⁷, A. Shui¹, S. Florman², F. Yao¹, N. Mehta¹
¹UCSF, SF, CA, ²Mt Sinai, NY, NY, ³U Penn, Philadelphia, PA, ⁴Scripps, La Jolla, CA, ⁵Stanford, Palo Alto, CA, ⁶U Michigan, Ann Arbor, MI, ⁷CPMC, SF, CA
*Purpose: Patients with HCC meeting UNOS-downstaging (DS) criteria (1 lesion 5.1-8 cm, 2-3 lesions at least one 3.1-5 cm and total tumor diameter (TTD) ≤8…
2021 American Transplant Congress
Assessing the Accuracy of the Lung Allocation Score
N. Dussault¹, W. Parker¹, R. Jablonski¹, E. Garrity¹, M. Churpek²
¹University of Chicago, Chicago, IL, ²University of Wisconsin-Madison, Madison, WI
*Purpose: The Lung Allocation Score (LAS) relies on the performance of two cox proportional hazards models that estimate waitlist and post-transplant survival. These models were…
2021 American Transplant Congress
T Cell Repertoire Diversity in HCV-Associated Hepatocellular Carcinoma Patients Waitlisted for Liver Transplantation and Receiving Liver-Directed Therapy
K. Nunez, T. Sandow, A. Cohen, P. Thevenot
Ochsner Health, New Orleans, LA
*Purpose: T cell receptor (TCR) sequencing in hepatocellular carcinoma (HCC) patients revealed a diverse TCR repertoire in hepatitis B-associated HCC-infiltrating T cells. In this study,…
2021 American Transplant Congress
Molecular Classifiers for Chronic Lung Allograft Dysfunction Transbronchial and Mucosal Biopsies Predict Clinical CLAD and Graft Loss
M. D. Parkes¹, P. F. Halloran², K. M. Halloran³, &. the INTERLUNG Study Group⁴
¹Alberta Transplant Applied Genomics Centre, Edmonton AB, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ³University of Alberta, Edmonton AB, AB, Canada, ⁴., ., AB, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) portends poor outcomes yet is poorly understood. In the multi-center INTERLUNG study we measured transcripts in transbronchial biopsies (TBBs)…
2021 American Transplant Congress
Donor Factors Associated with In-field Decline of Heart Allografts
L. Piechura, F. Yazdchi, M. Harloff, H. Shim, M. Keshk, A. Coppolino, III, D. Rinewalt, H. Mallidi
Brigham and Women's Hospital, Boston, MA
*Purpose: The decline of organs upon assessment within the field complicates optimal organ and resource utilization. We aimed to investigate if certain donor factors were…
2021 American Transplant Congress
Long Term Safety and Efficacy of Tocilizumab (anti-il6r, Tcz) Therapy in the Treatment of Refractory Chronic Antibody Mediated Rejection (cabmr) in 25 Pediatric Renal Transplant Recipients
M. Pearl¹, P. Weng¹, A. Dokras², H. Pizzo³, J. Garrison³, C. Butler¹, J. Q. Zhang¹, K. Lim³, E. Reed¹, I. Kim³, M. Haas³, X. Zhang³, R. Ettenger¹, S. Jordan³, D. Puliyanda³
¹Pediatric Nephrology, UCLA Medical Center, Los Angeles, CA, ²Pediatric Nephrology, UT South Western, Dallas, CA, ³Pediatric Nephrology, Cedars Sinai Medical Center, West Hollywood, CA
*Purpose: Development of de novo donor specific antibodies (DSA) post renal transplantation puts pediatric patients at risk for chronic Antibody Mediated Rejection (cABMR) and allograft…
2021 American Transplant Congress
Hla Antigens and Recurrence of Focal Segmental Glomerulosclerosis in Pediatric Kidney Transplantation
B. I. Shaw¹, A. Ochoa², C. Chan², R. A. Gbadegesin³, A. M. Jackson¹, E. T. Chambers³
¹Surgery, Duke University, Durham, NC, ²Biostatistics and Bioinformatics, Duke University, Durham, NC, ³Pediatrics, Duke University, Durham, NC
*Purpose: Recurrence of focal segmental glomerulosclerosis (FSGS) reduces graft survival yet risk factors remain elusive. While HLA risk alleles are known to be associated with…