Abstracts Archive - Page 323 of 1683 - ATC Abstracts

2021 American Transplant Congress
Single-cell Rna Sequencing of Latent Murine Cytomegalovirus Infected Lung Transplants
L. A. VanOsdol¹, S. Han¹, M. Kandpul², J. J. Wang¹, L. Qiu³, Z. J. Zhang¹
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL, ²Department of Surgery, Northwestern University, Chicago, IL, ³School of Medicine, University of California, San Fransisco, San Fransisco, CA
*Purpose: Analyze the transcriptomics of mouse lung cells with and without latent infection of cytomegalovirus (CMV) before and after transplantation and identify key cell types…
2021 American Transplant Congress
The Contribution of Disulfide-hmgb1 Released During Ischemia-reperfusion Injury to Pro-inflammatory Macrophage Polarization Following Liver Transplantation
A. Q. Terry, R. A. Sosa, M. Rossetti, J. Nevarez-Mejia, B. V. Naini, F. Kaldas, V. Groysberg, S. Younan, R. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. Reed
Pathology and Lab Medicine, UCLA, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) during liver transplantation (LT) is a pro-inflammatory response linked to poorer outcomes, including increased alloimmunity, post-LT. We previously showed that post-reperfusion…
2021 American Transplant Congress
Donor Lymphocytes in Peripheral Blood of Patients After Lung Transplantation Comprise High Frequencies of Killer Cell Immunoglobulin-like Receptor-positive T and NK Cell Subsets
J. F. Kühne¹, A. Hitz¹, K. A. Bläsing¹, B. Wiegmann², R. Bellmàs Sanz¹, F. Ius², A. Haverich², G. Warnecke², C. S. Falk¹
¹MHH, Institute of Transplant Immunology, Hannover, Germany, ²MHH, Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover, Germany
*Purpose: For end-stage lung diseases, lung transplantation (LuTx) is the only curative treatment option. However, acute and chronic rejections are major limitations. Thus, a deeper…
2021 American Transplant Congress
Transgenic Overexpression of Human Ectonucleoside Triphosphate Diphosphohydrolase 1 (entpd1, Or Hcd39) in Pig to Primate Xenotransplantation Models
R. Matheson¹, K. Deng¹, K. M. Lee¹, Z. A. Habibabady¹, C. G. Rickert¹, K. J. Ahrens¹, J. M. O¹, D. Becerra¹, P. Patel¹, W. Westlin², M. Youd², N. Serifis¹, T. M. Coe¹, D. Cloonan¹, A. M. Azimzadeh¹, C. LeGuern¹, J. C. Madsen¹, S. C. Robson³, J. F. Markmann¹
¹Transplantation Surgery Research, Massachusetts General Hospital, Boston, MA, ²eGenesis, Cambridge, MA, ³Beth Israel Deaconess Medical Center, Boston, MA
*Purpose: Human CD39 (hCD39) is the gene of interest in xenotransplantation due to its reported capacity to prevent platelet aggregation by metabolizing extracellular ATP to…
2021 American Transplant Congress
Effects of IL-2 and/ or Anti-IL6R Therapy on Long-term Cardiac Allograft Survival in Non-Human Primates (NHPs)
C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, J. A. Morrissette, D. Becerra, T. Costa, A. Dehnadi, I. M. Hanekamp, G. Benichou, J. C. Madsen
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Cardiac allograft tolerance in NHPs has been achieved by our group using a mixed chimerism model with allogeneic bone marrow transplant after non-myeloablative conditioning…
2021 American Transplant Congress
Myeloid YAP-HSF1 Signaling Inhibits NLRP3 Function and RIPK3-mediated Hepatocyte Necroptosis in Liver Ischemia and Reperfusion Injury
Y. Tian, D. Xu, M. Sheng, Y. Zhan, Y. Lin, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA
*Purpose: Yes-associated protein (YAP), a downstream effector of the Hippo pathway, tightly regulates cell growth, survival, and tissue inflammation. Activation of heat shock factor 1…
2021 American Transplant Congress
Characterization of Kidney Small Extracellular Vesicles Released During Normothermic Machine Perfusion
W. W. Woud¹, A. Arykbaeva², D. de Vries², I. Alwayn², K. Boer¹, C. Baan¹, M. Hoogduijn¹, R. Minnee³
¹Internal Medicine, Nephorology and Transplantation, Erasmus MC, Rotterdam, Netherlands, ²Department of Surgery, LUMC, Leiden, Netherlands, ³Department of Surgery, Division of Hepato-Pancreato-Biliary and Transplant Surgery, Erasmus MC, Rotterdam, Netherlands
*Purpose: By characterizing and quantifying the dynamical release of kidney Extracellular Vesicles (EVs) during Normothermic Machine Perfusion (NMP), we aim to gain a better understanding…
2021 American Transplant Congress
Galectin-3 Blockade Can Decrease Reperfusion Injury in Response to Ischemia in a Rat Hind Limb Transplant Model
Z. Wang¹, Y. Wang¹, D. Yoeli¹, B. Li¹, A. Su¹, D. Mathes¹, K. Washington¹, E. Farkash², C. A. Huang¹
¹University of Colorado, Aurora, CO, ²University of Michigan, Ann Arbor, Ann Arbor, MI
*Purpose: Vascularized composite allograft (VCA) transplant is technically feasible and results in successful clinical outcomes. However, skin and muscle containing VCA is highly susceptible to…
2021 American Transplant Congress
Lacripep^TM-like Peptide N-104 Increases Insulin Secretion and Promotes Islet Transplantation Outcomes
M. Ma, P. Chhabra, K. Dias Teixeira, G. Laurie, K. Brayman
University of Virginia Health System, Charlottesville, VA
*Purpose: To study if LacripepTM-like peptide N-104 promotes beta-cell stabilization and islet transplantation outcomes. Background: Lacritin is a multifunctional tear protein with prosecretory, prosurvival and…
2021 American Transplant Congress
Inhibition of Apoptosis During Ex Situ Liver Normothermic Machine Perfusion Decreases Reperfusion Injury and Improves Viability
S. Raigani¹, S. Baptista¹, A. Ohman², J. Santiago², I. Rosales¹, M. Heaney², J. Boylan², T. Coe¹, K. Uygun¹, J. Sanders², H. Yeh¹
¹Transplant Surgery, Massachusetts General Hospital, Boston, MA, ²Pediatric Endocrinology, Brown University, Providence, RI
*Purpose: Normothermic machine perfusion (NMP) is an ideal platform for delivery of novel therapeutics aimed at rehabilitation of discarded or marginal livers. We examined the…