Abstracts Archive - Page 317 of 1683 - ATC Abstracts

2021 American Transplant Congress
Suppression of T Cell Proliferation by Activated Nonhuman Primate B Cells
K. Lee, K. Deng, G. Huai, F. Qiang, C. Rickert, J. Lei, C. Leguern, J. Markmann
Massachusetts General Hospital, Boston, MA
*Purpose: We previously generated Toll-like receptor (TLR)-activated B cells in rodent settings. These B cells can suppress T cell proliferation via in vitro mixed lymphocytes…
2021 American Transplant Congress
Donor Kidney-Resident Macrophages Promote Allograft Inflammation and CD8 T Cell Response Post-Transplantation
A. Dangi¹, S. Yu², I. Husain¹, R. Geesala¹, X. Luo¹
¹Nephrology, Medicine, Duke University, Durham, NC, ²Division of Organ Transplantation, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Kidney-resident macrophages play important roles in maintaining normal kidney function and promoting prompt repair following kidney injuries. Nevertheless, their fate and role in kidney…
2021 American Transplant Congress
Environmental Factors That Shape T-cell Alloimmunity: Role of the Microbiome
K. Janek¹, J. H. Fechner¹, R. A. Daley¹, K. Krautkamer¹, F. Rey², J. D. Mezrich¹
¹Surgery, University of Wisconsin School of Medicine & Public Health, Madison, WI, ²Bacteriology, University of Wisconsin, Madison, WI
*Purpose: Unlike other types of immunity, T-cell alloimmune responses to mismatched MHC proteins do not need priming by a previous exposure. While genetic differences between…
2021 American Transplant Congress
Robotic Donor Nephrectomy: Advantages Offered by a Minimally Invasive Approach to Kidney Transplantation
A. Popovic¹, R. Shahbazov¹, A. Hoste¹, S. Loerzel¹, B. Gallay², J. Leggat², O. Pankewycz¹, R. Saidi¹, R. H. Dvorai³, M. J. Hanlon¹, S. Narsipur², M. R. Laftavi¹
¹Surgery, SUNY Upstate Medical University, Syracuse, NY, ²Medicine, SUNY Upstate Medical University, Syracuse, NY, ³Pathology, SUNY Upstate Medical University, Syracuse, NY
*Purpose: Our aim was to further explore the difference in results between laparoscopic and robotic assisted techniques of living donor nephrectomies*Methods: This is a retrospective…
2021 American Transplant Congress
Novel Morphologic Biomarkers of Cardiac Allograft Remodeling are Associated with Multiple Peri- and Post-transplant Inflammatory Processes
C. Yuan¹, S. Arabyarmohammadi¹, H. Li¹, E. Peyster², P. Lal³, M. Feldman³, K. Margulies², A. Madabhushi¹
¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, ²Cardiovascular Research Institute, University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, PA
*Purpose: It has long been recognized that transplanted hearts develop a stiffened, restrictive physiology at an accelerated rate compared to native hearts. While this is…
2021 American Transplant Congress
Neutrophil CEACAM1 Induces Hepatic Autophagy and Shapes Innate-adaptive Immune Response in Liver Transplantation: From Mouse-to-human
H. Hirao¹, H. Kojima¹, K. Kadono¹, K. J. Dery¹, K. Nakamura², D. G. Farmer¹, F. M. Kaldas¹, J. W. Kupiec-Weglinski¹
¹Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, ²Surgery, Kyoto University, Kyoto, Japan
*Purpose: Although CEACAM1 (CC1; carcinoembryonic antigen-related cell adhesion molecule 1; CD66a) regulates innate-adaptive immunity, its role in orthotopic liver transplantation (OLT) remains unknown. CC1 expresses…
2021 American Transplant Congress
Portal Hypertension Abrogates Trail Expression of Liver Resident Nk Cells via Il-33
Y. Imaoka, M. Ohira, K. Sato, H. Ohdan
Hiroshima Uni., Hiroshima, Japan
*Purpose: Portal vein hypertension (PHT) is associated with poor prognosis, risk factors for small graft syndrome, bloodstream infection, and acute rejection after living donor liver…
2021 American Transplant Congress
Quantifying Hidden Sensitization: HLA-reactive Memory B Cells in the Spleens of Sensitized Women
J. T. Killian¹, J. A. Houp¹, A. Nellore², R. G. King³, P. M. Porrett¹, F. E. Lund³
¹Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL, ²Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL, ³Department of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL
*Purpose: Measurement of circulating anti-HLA antibody (anti-HLA-Ab) in transplant candidates and recipients is required for successful organ transplantation. However, serum Ab measurement alone likely underestimates…
2021 American Transplant Congress
Mhealth Family Self-Management Intervention for Families of Transplanted Children
S. M. Lerret¹, R. White-Traut², B. Medoff-Cooper³, S. I. Ahamed⁴, P. Simpson⁵, R. Schiffman⁶
¹Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, ²Children's Wisconsin, Milwaukee, WI, ³University of Pennsylvania, Philadelphia, PA, ⁴Department of Computer Science, Marquette University, Milwaukee, WI, ⁵Department of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, ⁶University of Wisconsin Milwaukee, Milwaukee, WI
*Purpose: Nearly 2,000 children undergo solid organ transplant in the US annually. In our previous research with transplant families, parents reported difficulty coping with the…
2021 American Transplant Congress
Effects of IL-18 on Key Post-Translational Modifications of Human Foxp3 and Innate Immunity
T. Akimova¹, L. M. Christensen¹, Z. Wang², M. H. Levine², W. W. Hancock¹
¹CHOP & University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA
*Purpose: Most of our ideas about Treg cells are extrapolated from findings in mice, with actual clinical data typically involving flow cytometric enumeration of CD4+FOXP3+…