Abstracts Archive - Page 316 of 1683 - ATC Abstracts

2021 American Transplant Congress
The Tumor-suppressor Signaling of the α1-na/k-atpase- Cav-1-src Complex at the Caveola in Nash Related Hepatocellular Carcinoma
U. S. Udoh¹, J. D. Sanabria¹, M. Banerjee¹, P. K. Rajan¹, M. Schade¹, J. A. Sanabria¹, A. Mallick¹, G. Smith¹, G. U. Udoh², K. Sodhi¹, S. Pierre², Z. Xie², J. Shapiro², J. Sanabria¹
¹Dept. of Surgery/ Marshall Institute for Interdisciplinary Research, Marshall University, Huntington,, WV, ²Marshall Institute for Interdisciplinary Research, Marshall University, Huntington,, WV
*Purpose: Hepatocellular Carcinoma (HCC) is the 2nd and fastest-growing cause of cancer related mortality worldwide, mainly from the metabolic cellular disturbances promoted by the epidemic…
2021 American Transplant Congress
Primary Uretero-ureterostomy in Renal Transplantation
H. Shokouh-Amiri¹, M. S. Naseer¹, D. Aultman¹, R. McMillan¹, S. Tandukar², F. T. Siskron³, N. Singh², G. Zibari¹
¹Advanced Surgery, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, ²Transplant Nephrology, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, ³Urology, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA
*Purpose: Uretero-neocystostomy (UN) is routinely performed in renal transplantation. Few studies of primary uretero-ureterostomy (UU) have been reported, showing its safety and feasibility. If the…
2021 American Transplant Congress
HLA I Antibody-Activated Endothelium Polarized M2-Like Macrophages with Increased Efferocytic and Phagocytic Capacity
J. Nevarez-Mejia¹, X. Wei¹, N. M. Valenzuela¹, M. Rossetti¹, H. Pickering¹, G. A. Fishbein¹, A. Mulder², E. F. Reed¹
¹Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, ²Immunohematology and Blood Transfusion, LUMC, Leiden, Netherlands
*Purpose: The role of intragraft macrophages (Mϕs) during antibody-mediated rejection (AMR) remains unclear. Anti-HLA Abs during AMR drives vascular inflammation as seen by monocyte recruitment…
2021 American Transplant Congress
Transgenic Beta-cell Cxcl12 Expression and Stem Cell Mobilization Synergize to Suppress Type 1 Diabetes
D. A. Alagpulinsa, A. Jajoo, M. H. Chapin II, M. C. Poznansky
Vaccine & Immunotherapy Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Hematopoietic stem and progenitor cells (HSPCs) and regulatory T cells (Tregs) highly express CXCR4, the receptor for the CXCL12 chemokine. This keeps them predominantly…
2021 American Transplant Congress
Quantifying Hidden Sensitization: HLA-reactive Memory B Cells in the Spleens of Sensitized Women
J. T. Killian¹, J. A. Houp¹, A. Nellore², R. G. King³, P. M. Porrett¹, F. E. Lund³
¹Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL, ²Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL, ³Department of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL
*Purpose: Measurement of circulating anti-HLA antibody (anti-HLA-Ab) in transplant candidates and recipients is required for successful organ transplantation. However, serum Ab measurement alone likely underestimates…
2021 American Transplant Congress
Extracellular Vesicles from Patients with Diabetic Nephropathy Induce Endothelial Dysfunction Through Icam-1 and Vcam-1 in an In Vitro Model
E. Montagud-Marrahi¹, S. Torramadé-Moix², M. Ramirez-Bajo³, J. Rovira³, E. Bañón-Maneus³, E. Hermida¹, F. Diekmann¹, M. Palomo⁴, M. Díaz-Ricart², P. Ventura-Aguiar¹
¹Nephrology and Kidney Transplantation Department, Hospital Clínic de Barcelona, Barcelona, Spain, ²Hematopathology Department, Hospital Clínic de Barcelona, Barcelona, Spain, ³Nephrology and Transplant Experimental Laboratory (LENIT), Hospital Clínic de Barcelona, Barcelona, Spain, ⁴Josep Carreras Leukaemia Research Institute, Hospital Clínic de Barcelona, Barcelona, Spain
*Purpose: Extracellular Vesicles (EVs) are membranous structures produced by cells which contain different cytoplasmic compounds and that have been described as potentially pathogenic elements in…
2021 American Transplant Congress
IFNγ, and to a Lesser Extent TNFα, Elicits Protracted Endothelial Cell Expression of Costimulatory Molecules and Antigen Presentation Machinery
N. M. Valenzuela
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
*Purpose: Beyond simply “recruiting” leukocytes to sites of injury, local stimulation by the donor vascular compartment may prolong alloimmune responses. Moreover, the dynamics of endothelial…
2021 American Transplant Congress
Human Liver-derived Mesenchymal Stromal Cells (MSC) are Superior Inhibitors of Natural Killer Cells Compared to Bone Marrow or Adipose Tissue-derived MSC
F. Yigitbilek, M. J. Hansen, W. D. Park, M. D. Stegall, T. Taner
Mayo Clinic, Rochester, MN
*Purpose: Guided by the liver allografts’ unique tolerogenic microenvironment and the immunoprotective impact on simultaneously transplanted organs, we recently isolated liver mesenchymal stromal cells (L-MSC)…
2021 American Transplant Congress
In Vitro Generated Regulatory B Cells Induce Cd4⁺Cd25⁺Foxp3⁺Tregs from Cd4⁺Cd25^–T Cells via TGF-β
G. Huai¹, K. Lee², K. Deng², Q. Fu¹, C. G. Rickert², S. Deng¹, C. LeGuern², J. F. Markmann²
¹Department of Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: Our team previous study showed that TLR-Bregs, stimulated through TLR pathway in vitro, harbored regulatory properties by suppressing CD4+ T cell proliferation and function…
2021 American Transplant Congress
Addressing a Need in Transplant Clinical Care: Creation of the Organ Transplant Caregiver Toolkit
H. Bruschwein¹, G. Chen², A. Ortega³, W. Balliet⁴, T. Coco⁵, C. Thomas⁶, B. Hansen⁵, D. Richardson⁷, K. Canavan⁸, C. Burch⁹, A. Yaldo¹⁰, M. Jesse¹¹
¹University of Virginia School of Medicine, Charlottesville, VA, ²Memorial Hermann Transplant Center, Houston, TX, ³Memorial Transplant Institute, Miami, FL, ⁴Medical University of South Carolina, Charleston, SC, ⁵Mayo Clinic, Pheonix, AZ, ⁶Banner Transplant Institute, Pheonix, AZ, ⁷Caregiver, Minburn, IA, ⁸National Kidney Foundation, New York, NY, ⁹Stanford Children's Hospital, Palo Alto, CA, ¹⁰University of Michigan, Ann Arbor, MI, ¹¹Henry Ford Transplant Institute, Detroit, MI
*Purpose: Lay or informal caregivers are a critical component of pre- and post-operative care in adult organ transplantation and living donation. Caregiving in organ transplantation…