Abstracts Archive - Page 299 of 1683 - ATC Abstracts

2021 American Transplant Congress
Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts
V. Gorbacheva, R. Fan, W. Baldwin, R. Fairchild, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Production of high affinity isotype-switched donor specific alloantibodies (DSA) after transplantation is associated with germinal center formation by follicular (FO) B cells whereas the…
2021 American Transplant Congress
Acoustofluidic Device to Remove Donor Specific Antibody in a Sensitized Animal Model
J. Kwun¹, E. David², Y. Gu³, Z. Ma³, M. Kuchibhatla⁴, G. Arepally⁵, T. J. Huang³, E. T. Chambers²
¹Surgery, Duke University, Durham, NC, ²Pediatrics, Duke University, Durham, NC, ³Biomedical Engineering, Duke University, Durham, NC, ⁴Biostatistics and Bioinformatics, Duke University, Durham, NC, ⁵Internal Medicine, Duke University, Durham, NC
*Purpose: Current therapies for antibody-mediated rejection are neither donor-specific nor are they tailored toward children, resulting in premature allograft loss and increased mortality. Apheresis involves…
2021 American Transplant Congress
The Benefits of Sharing Non-Directed Donors Nationally Through Paired Exchange
J. Verbesey¹, A. G. Thomas², A. D. Waterman³, J. Vucci¹, G. Vranic¹, A. Gilbert¹, S. Ghasemian¹, M. Cooper¹
¹Georgetown University Hospital, Washington, DC, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³UCLA, Los Angeles, CA
*Purpose: Non-directed donors (NDDs) are a valuable resource that can “unlock” incompatible transplants. Recent advances in paired kidney exchange (PKE) suggest that NDDs may facilitate…
2021 American Transplant Congress
20 Year Survival Following Lung Transplantation
R. M. Reul, Jr¹, S. Barrett¹, A. Alnajar², J. Dunson¹, P. S. Garcha³, G. Loor⁴, J. A. Goss⁴, A. A. Rana⁴
¹Office of Student Affairs, Baylor College of Medicine, Houston, TX, ²Department of Surgery, University of Miami Health System, Miami, FL, ³Department of Medicine, Baylor College of Medicine, Houston, TX, ⁴Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX
*Purpose: Outcomes following lung transplantation (LTx) have been poor compared to those of heart, liver, and kidney transplants, with 5-year survival rates around 50%. To…
2021 American Transplant Congress
Early Stent Removal in Kidney Transplant Recipients – A Quality Improvement Project
V. Rohan, N. Pilch, M. Altiti, S. Nadig, A. Lin, D. DuBay, P. Baliga
Surgery, Medical University of South Carolina, Charleston, SC
*Purpose: Ureteric Stent placement is a is common practice at the time of kidney transplantation to reduce the incidence and severity of Major Urological Complications…
2021 American Transplant Congress
Low Immunogenic Donors Improve Kidney Transplant Survival in Sensitized Recipients
D. Bekbolsynov¹, R. Green², B. Mierzejewska¹, M. Rees¹, S. Stepkowski¹
¹University of Toledo, Toledo, OH, ²Bowling Green State University, Bowling Green, OH
*Purpose: Our previous results showed that low immunogenicity (IM) donors improved kidney allograft survival in non-sensitized recipients. Herein, we examined how the level of peak…
2021 American Transplant Congress
Cd4 T Cells Can Trigger Nk-dependent Chronic Rejection Independent of Antibodies
R. G. Gill¹, B. Mehrad², C. M. Lin²
¹Surgery, University of Colorado Denver, Aurora, CO, ²Medicine, University of Florida, Gainesville, FL
*Purpose: In transplantation, recipient CD4+ T cells have two potential means of MHC class II-restricted donor antigen detection: (1) the direct recognition of allogeneic MHC…
2021 American Transplant Congress
Lung Transplant Recipients with Severe Acute Respiratory Syndrome-Coronavirus 2 Infection and Asymptomatic Carriers Waiting for Lung Transplantation Induce Circulating Exosomes with Severe Acute Respiratory Syndrome-Coronavirus 2 Spike Protein S2
S. Bansal, S. Tokman, T. Fleming, M. Smith, R. Bremner, T. Mohanakumar
St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Exosomes are vesicles released by cells into body fluids. We demonstrated increased circulating exosomes with lung self-antigens (Collagen V, Kα1 Tubulin) and viral antigens…
2021 American Transplant Congress
The Impact of Donor and Recipient Age Differenceon Long Term Prognosis in Young Liver Transplant Recipients
A. Pita, A. Moro, J. C. McVey, D. J. Firl, M. Fujiki, T. Diago, C. Quintini, F. Aucejo, C. D. Kwon, K. V. Menon, K. Hashimoto, B. Eghtesad, C. Miller, K. Sasaki
The Cleveland Clinic, Cleveland, OH
*Purpose: Although the importance of donor and recipient age in liver transplant (LT) are well-studied, the prognostic influences of donor and recipient age differences are…
2021 American Transplant Congress
Use of a Novel Bead-based Assay to Measure the Impact of Imlifidase on ABO IgG Antibodies
A. Halpin¹, B. Motyka², T. Ellis², J. Pearcey², T. L. Lowary³, A. Runström⁴, L. Winstedt⁴, R. Bockermann⁴, S. Järnum⁴, A. Robertson⁴, L. J. West⁵
¹Department of Pediatrics and Laboratory Medicine and Pathology, University of Alberta and Alberta Precision Laboratories, Edmonton, AB, Canada, ²Department of Pediatrics, University of Alberta, Edmonton, AB, Canada, ³Department of Chemistry, University of Alberta, Edmonton, AB, Canada, ⁴Hansa Biopharma, Lund, Sweden, ⁵Department of Pediatrics and Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
*Purpose: The accurate assessment and measurement of ABO antibodies (ABO-Ab) is a critical component of ABO-incompatible (ABOi) transplantation. ABO-Ab comprise both IgG and IgM, which…