Abstracts Archive - Page 283 of 1683 - ATC Abstracts

2021 American Transplant Congress
Polyfunctional T-cell Impairment to Sars-cov-2 Coronavirus in Solid Organ Transplant Recipients with Acute Covid-19 Infection
A. Favà¹, L. Donadeu², V. Pernin³, M. Meneghini¹, E. Crespo², N. Sabé⁴, L. Lladó⁵, J. Gonzalez-Costello⁶, O. Thaunat⁷, O. Bestard¹
¹Kidney Transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, ²Experimental Nephrology Laboratory, IDIBELL, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, ³Kidney Transplant Unit, Hospital de Montpellier, Montpellier, France, ⁴Infectious Disease Department, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, ⁵Liver Transplant Unit, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, ⁶Heart Transplantation Unit, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, ⁷Department of Transplantation, Edouard Herriot Hospital Lyon, Lyon, France
*Purpose: The emerged COVID-19 pandemic caused by SARS-CoV-2 has paralyzed the world, due to its high infectivity and fatal outcomes, especially among more vulnerable individuals.…
2021 American Transplant Congress
Donor Derived Transmissions 2019: Analysis of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC)
L. Danziger-Isakov¹, M. G. Michaels¹, A. Agarwal¹, S. Aslam¹, K. Dunn¹, J. Goldman¹, D. Levine¹, C. Marboe¹, G. Marklin¹, S. Pouch¹, M. Rana¹, R. Razonable¹, H. L. Stevenson¹, H. S. Te¹, A. Woolley¹, E. Ward², C. Jett², L. Cartwright², R. La Hoz¹
¹OPTN DTAC, Richmond, VA, ²UNOS, Richmond, VA
*Purpose: The OPTN DTAC, a multidisciplinary group, evaluates potential donor derived transmission events (PDDTE), mostly infections (I) & malignancies (M), to assess the likelihood of…
2021 American Transplant Congress
Longitudinal Antibody Response and Viral Loads in Covid-infected Organ Transplant Recipients
T. M. Marinelli, V. H. Ferreira, M. Ierullo, V. Kulasingham, B. Majchrzak-Kita, C. Rotstein, S. Husain, S. Hosseini, A. Humar, D. Kumar
UHN, Toronto, ON, Canada
*Purpose: The full spectrum of COVID-19 disease and the impact of disease severity on antibody response and viral shedding dynamics in transplant patients is unclear.…
2021 American Transplant Congress
Systematic Screening of Kidney Transplant Patients Points Towards Deficits in Neutralizing Antibody Capacity Against Sars-cov-2
V. Wijtvliet¹, K. K. Ariën², J. Mariën², B. Peeters³, R. Hellemans⁴, A. Massart⁴, S. Van Hees¹, P. Moons⁵, H. Theeten⁶, P. Van Damme⁶, H. Goossens⁷, B. Y. De Winter¹, K. J. Ledeganck¹, D. Abramowicz⁴
¹Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium, ²Department of Biomedical Sciences, Institute of Tropical Medicine and University of Antwerp, Antwerp, Belgium, ³Department of Laboratory Medicine, Antwerp University Hospital, Antwerp, Belgium, ⁴Department of Nephrology and Hypertension, Antwerp University Hospital, Antwerp, Belgium, ⁵Biobank, Antwerp University Hospital, Antwerp, Belgium, ⁶Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium, ⁷Department of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium
*Purpose: The majority of kidney transplant recipients (KTR) is able to develop SARS-CoV-2 antibodies (Abs). Little is known about the virus neutralizing capacity of these…
2021 American Transplant Congress
The Gut Microbiome in Heart Transplantation: A Prospective Pilot Study
M. Dela Cruz¹, E. Littmann², R. Nayak², C. Lehmann², R. Keskey³, T. Baker³, H. Lin², A. Bennett¹, G. Kim¹, S. Pinney¹, E. Pamer², A. B. Nguyen¹
¹Cardiology, University of Chicago, Chicago, IL, ²Medicine, University of Chicago, Chicago, IL, ³Surgery, University of Chicago, Chicago, IL
*Purpose: The contribution of the intestinal microbiome to alloimmunity in heart transplantation (HT) is unknown. We examined the fecal microbiota of HT recipients at the…
2021 American Transplant Congress
Early Detection of SARS-CoV-2 and Other Infections in Solid Organ Transplant Recipients and Household Members Using Wearable Devices
E. H. Li¹, E. Mukhtar¹, E. D. Elftmann¹, F. R. Eweje¹, H. Gao¹, L. I. Ibrahim¹, R. G. Kathawate¹, A. C. Lee¹, K. A. Moore¹, N. Nair¹, S. Amaral², M. Snyder³, B. J. Keating¹
¹Department of Surgery, Penn Transplant Institute, Division of Transplantation, Philadelphia, PA, ²Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Department of Genetics, Stanford University, Palo Alto, CA
*Purpose: Wearable devices that measure physiological parameters have shown utility for detecting infections such as influenza and recently COVID-19 up to 10 days before clinical…
2021 American Transplant Congress
Clinical Outcomes and Racial Impact of HLA Matching in the Australian Deceased Donor Kidney Transplantation Program, 2000-2018
M. Gramlick, M. Heer
Department of Surgery, John Hunter Hospital, Newcastle, Australia
*Purpose: The Australian deceased donor (DD) kidney transplant program places a large emphasis on HLA matching despite a known disadvantage to ethnic minority groups. We…
2021 American Transplant Congress
T-cell-Mediated Immunity to Sars-cov-2 Defines Covid-19 Risk and Severity in Transplanted and Non-Transplanted Individuals and Associates with Myeloid-Derived Suppressor Cells
C. Ashokkumar¹, V. Rohan², A. H. Kroemer³, S. Rao⁴, G. Mazariegos⁵, B. W. Higgs⁵, S. Nadig², M. Ningappa⁵, T. Fishbein³, S. Subramaniam⁶, R. Sindhi⁷
¹Plexision, Pittsburgh, PA, ²Medical University of South Carolina, Charleston, SC, ³MedStar Georgetown Transplant Institute, Georgetown, DC, ⁴DHR Health Institute for Research and Development, Texas, TX, ⁵University of Pittsburgh, Pittsburgh, PA, ⁶University of California, San Diego, CA, ⁷University of Pittsburgh, pittsburgh, PA
*Purpose: We assessed whether COVID-19-risk is enhanced by chronic immunosuppression, and is associated with suppressor cells.*Methods: We tested 66 COVID-19 patients, including 26 with solid…
2021 American Transplant Congress
Combined CD11b/CD40 Blockade is Superior to CD40 Blockade Alone in Prolonging Survival in Pig-to-Nonhuman Primate Renal Xenotransplantation
D. A. Faber¹, B. Lovasik¹, A. Matar¹, C. Breeden¹, S. Kim¹, A. Adams²
¹Surgery, Emory University School of Medicine, Atlanta, GA, ²Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Blockade of the CD40/CD154 pathway is highly effective in preventing rejection in pig-to-nonhuman primate (NHP) xenotransplantation models. Clinical translation of anti-CD154 mAbs, however, has…
2021 American Transplant Congress
Impact of CHA2DS2-VASc Score on Postoperative Mortality Following Kidney Transplant
J. Klein¹, M. Rangel¹, Z. Spigel², E. Hollinger¹, D. Olaitan¹, M. Hertl¹, E. Chan¹
¹Surgery, Rush University Medical Center, Chicago, IL, ²Surgery, Allegheny Health Network, Pittsburgh, PA
*Purpose: This study aimed to assess the correlation between CHA2DS2-VASc score and postoperative kidney transplant survival. The conditions captured in the CHA2DS2-VASc score are commonly…