Abstracts Archive - Page 225 of 1683 - ATC Abstracts

2021 American Transplant Congress
Characterisation of Distinct Graft Infiltrates Following Cellular Therapy in Kidney Transplant Recipients
M. O. Brook¹, P. N. Harden², I. Roberts², W. R. Mulley³, J. Hester¹, M. E. Reinders⁴, F. Issa¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom, ³Department of Nephrology, Monash Medical Centre, Melbourne, Australia, ⁴Division of Nephrology and Transplant Center, Leiden University Medical Center, Leiden, Netherlands
*Purpose: Cellular therapy is an emerging treatment in the field of clinical transplantation with the potential to improve both short and long-term transplant outcomes. We…
2021 American Transplant Congress
A Noninvasive Diagnostic Approach for Molecular Monitoring of Face Transplant Recipients
C. Snopkowski¹, P. Rabbani², H. Yang¹, Z. Berman², G. Diep², C. Li¹, T. Muthukumar¹, R. Ding¹, D. Ceradini², M. Suthanthiran¹
¹Weill Cornell Medical Institute, Department of Medicine, Division of Nephrology, NY, NY, ²NYU Langone Health, Hansjörg Wyss Department of Plastic Surgery, NY, NY
*Purpose: Skin biopsies are currently the gold standard for evaluating the inflammatory status of face allografts. However, “tape stripping” is emerging as a noninvasive technique…
2021 American Transplant Congress
T-cell-Mediated Immunity to Sars-cov-2 Defines Covid-19 Risk and Severity in Transplanted and Non-Transplanted Individuals and Associates with Myeloid-Derived Suppressor Cells
C. Ashokkumar¹, V. Rohan², A. H. Kroemer³, S. Rao⁴, G. Mazariegos⁵, B. W. Higgs⁵, S. Nadig², M. Ningappa⁵, T. Fishbein³, S. Subramaniam⁶, R. Sindhi⁷
¹Plexision, Pittsburgh, PA, ²Medical University of South Carolina, Charleston, SC, ³MedStar Georgetown Transplant Institute, Georgetown, DC, ⁴DHR Health Institute for Research and Development, Texas, TX, ⁵University of Pittsburgh, Pittsburgh, PA, ⁶University of California, San Diego, CA, ⁷University of Pittsburgh, pittsburgh, PA
*Purpose: We assessed whether COVID-19-risk is enhanced by chronic immunosuppression, and is associated with suppressor cells.*Methods: We tested 66 COVID-19 patients, including 26 with solid…
2021 American Transplant Congress
Myeloid Foxo1-β-catenin Axis Regulates Hedgehog/Gli1 Signaling and Controls NLRP3-Mediated Innate Immune Responses in Sterile Inflammatory Liver Injury
D. Xu, C. Li, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: Foxo1 plays important roles in cell metabolism, oxidative stress, inflammation, and apoptosis. Activation of Hedgehog/Gli1 signaling regulates cell growth, differentiation, and immune function. However,…
2021 American Transplant Congress
Peripheral Blood Hematopoietic Chimerism: A Robust Biomarker for Transplantation Tolerance
D. Tollerud¹, E. Gornstein¹, J. Leventhal², K. V. Ravindra³, S. Ildstad¹
¹Talaris Therapeutics, Louisville, KY, ²Division of Organ Transplantation, Northwestern Medical Group, Chicago, IL, ³Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Despite the development of highly effective immunosuppressive medications, organ rejection and the toxicity of the drugs themselves remain significant obstacles to long-term graft and…
2021 American Transplant Congress
The Gut Microbiome in Heart Transplantation: A Prospective Pilot Study
M. Dela Cruz¹, E. Littmann², R. Nayak², C. Lehmann², R. Keskey³, T. Baker³, H. Lin², A. Bennett¹, G. Kim¹, S. Pinney¹, E. Pamer², A. B. Nguyen¹
¹Cardiology, University of Chicago, Chicago, IL, ²Medicine, University of Chicago, Chicago, IL, ³Surgery, University of Chicago, Chicago, IL
*Purpose: The contribution of the intestinal microbiome to alloimmunity in heart transplantation (HT) is unknown. We examined the fecal microbiota of HT recipients at the…
2021 American Transplant Congress
Clinical Outcomes of Solid Organ Transplant Recipients Treated with Remdesivir and Convalescent Plasma for Covid-19 at the Largest Transplant Center in the United States
A. Fernandez, S. Anjan, A. Chandorkar, D. de Lima, R. Zamora, L. A. Mendez-Castaner, J. Simkins, J. Camargo, M. Morris, M. Loebe, J. Bauerlein, C. O’Brien, N. Sinha, G. Burke, G. Ciancio, A. Mattiazzi, R. Vianna, L. Abbo, G. Guerra, Y. Natori
Miami Transplant Institute, Jackson Health System, Miami, FL
*Purpose: Solid organ transplant recipients (SOTr) are at high risk for severe disease with SARS-CoV-2. Data on efficacy of potential treatment options and long-term outcomes…
2021 American Transplant Congress
Systematic Screening of Kidney Transplant Patients Points Towards Deficits in Neutralizing Antibody Capacity Against Sars-cov-2
V. Wijtvliet¹, K. K. Ariën², J. Mariën², B. Peeters³, R. Hellemans⁴, A. Massart⁴, S. Van Hees¹, P. Moons⁵, H. Theeten⁶, P. Van Damme⁶, H. Goossens⁷, B. Y. De Winter¹, K. J. Ledeganck¹, D. Abramowicz⁴
¹Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium, ²Department of Biomedical Sciences, Institute of Tropical Medicine and University of Antwerp, Antwerp, Belgium, ³Department of Laboratory Medicine, Antwerp University Hospital, Antwerp, Belgium, ⁴Department of Nephrology and Hypertension, Antwerp University Hospital, Antwerp, Belgium, ⁵Biobank, Antwerp University Hospital, Antwerp, Belgium, ⁶Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium, ⁷Department of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium
*Purpose: The majority of kidney transplant recipients (KTR) is able to develop SARS-CoV-2 antibodies (Abs). Little is known about the virus neutralizing capacity of these…
2021 American Transplant Congress
Racial/ethnic and Sex Disparities in Renal Transplant Waitlisting Accounting for Pre-Waitlist Mortality
R. Hamoda¹, R. Patzer², M. Saunders¹
¹University of Chicago, Chicago, IL, ²Emory University, Atlanta, GA
*Purpose: The purpose of this study was to assess racial/ethnic and sex differences in access to the renal transplant deceased donor waiting list among incident…
2021 American Transplant Congress
Solid Organ Transplant Recipient Attitudes Towards a SARS-CoV-2 Vaccine
M. Ou¹, B. Boyarsky¹, L. Zeiser¹, T. Chiang¹, J. Ruddy¹, S. Rasmussen¹, J. Martin², J. Russell², C. Durand¹, R. Avery¹, W. Werbel¹, M. Cooper³, A. Massie¹, D. Segev¹, J. Garonzik-Wang¹
¹Johns Hopkins, Baltimore, MD, ²National Kidney Foundation, New York, NY, ³Medstar Georgetown Transplant Institute, Washington, DC
*Purpose: An effective and widely-accepted SARS-CoV-2 vaccine could protect the community and vulnerable populations. We investigated the attitudes of solid organ transplant recipients (SOTRs) towards…