Abstracts Archive - Page 224 of 1683 - ATC Abstracts

2021 American Transplant Congress
Review of Outcomes After Diagnosis of Malignancy in Kidney Transplant Patients: Unos Database
H. Patel¹, N. Agrawal¹, R. Gupta¹, P. Geetha², A. Abdul Razzack³, F. Cardarelli¹
¹Transplant Nephrology, Beth Israel Deaconess Medical Center, Boston, MA, ²Nephrology, Beth Israel Deaconess Medical Center, Boston, MA, ³Medicine, Dr. NTR University of Health Sciences, Vijaywada, India
*Purpose: Malignancy is the third major cause of death among transplant recipients. Among the transplant recipients, Patient and kidney transplant outcomes after the diagnosis of…
2021 American Transplant Congress
Lung Transplantation After Ex-Vivo Lung Perfusion versus Static Cold Storage: A Single Institution Cost Analysis
S. E. Halpern¹, S. J. Kesseli², S. Au¹, M. K. Krischak¹, D. G. Olaso¹, H. Smith³, G. Tipton², I. Jamieson³, J. C. Haney², J. A. Klapper², M. G. Hartwig²
¹Duke University School of Medicine, Durham, NC, ²Surgery, Duke University Medical Center, Durham, NC, ³Office of Finance, Duke Transplant Center, Durham, NC
*Purpose: Ex-vivo lung perfusion (EVLP) allows for reconditioning of “marginal” lung grafts and extended lung preservation. However, EVLP is costlier than cold storage. We compared…
2021 American Transplant Congress
Myeloid Foxo1-β-catenin Axis Regulates Hedgehog/Gli1 Signaling and Controls NLRP3-Mediated Innate Immune Responses in Sterile Inflammatory Liver Injury
D. Xu, C. Li, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: Foxo1 plays important roles in cell metabolism, oxidative stress, inflammation, and apoptosis. Activation of Hedgehog/Gli1 signaling regulates cell growth, differentiation, and immune function. However,…
2021 American Transplant Congress
Combined CD11b/CD40 Blockade is Superior to CD40 Blockade Alone in Prolonging Survival in Pig-to-Nonhuman Primate Renal Xenotransplantation
D. A. Faber¹, B. Lovasik¹, A. Matar¹, C. Breeden¹, S. Kim¹, A. Adams²
¹Surgery, Emory University School of Medicine, Atlanta, GA, ²Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Blockade of the CD40/CD154 pathway is highly effective in preventing rejection in pig-to-nonhuman primate (NHP) xenotransplantation models. Clinical translation of anti-CD154 mAbs, however, has…
2021 American Transplant Congress
Stem Cell and Novel Neurotrophic Factors to Promote Functional Outcomes in Limb Transplantation
S. K. Salgar¹, J. Weiss², C. Phillips², E. Malin², V. Gorantla³, J. Harding⁴
¹Clinical Investigation, United States Army, Tacoma, WA, ²Clinical Investigation, Madigan Army Medical Center, Tacoma, WA, ³Surgery, Wake Forest University, Winston-Salem, NC, ⁴Neuroscience, Washington State Universisty, Pullman, WA
*Purpose: Recently, transplantation of hand and face has become a new clinical specialty. The objective of this study was to determine whether adult Mesenchymal Stem…
2021 American Transplant Congress
A Multi-institutional Study of Renal Outcomes in Uterus Transplantation
D. Sawinski¹, L. Johannesson², J. Kristen³, J. Fronek³, P. Porrett⁴
¹Hospital of the University of Pennsylvania, Philadelphia, PA, ²Department of Surgery, Baylor University Medical Center, Dallas, TX, ³Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁴University of Alabama at Birmingham, Birmingham, AL
*Purpose: Pregnancy and calcineurin inhibitor-based immunosuppression represent potential renal stressors for uterus transplant (UTx) recipients, many of whom have Mayer-Rokitanksy-Kuster-Hauser (MRKH) syndrome and associated renal…
2021 American Transplant Congress
A Single Nucleotide Polymorphism within the FCGR3A 158 F/V Gene is Associated with Decreased Survival of Renal Allografts with Chronic Active Antibody-Mediated Rejection
N. H. Litjens, A. M. Peeters, J. A. Kal-van Gestel, M. Klepper, M. G. Betjes
Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands
*Purpose: Long-term allograft survival has shown little improvement over the last decades. An important factor compromising long-term allograft survival in kidney transplantation is chronic active…
2021 American Transplant Congress
A Noninvasive Diagnostic Approach for Molecular Monitoring of Face Transplant Recipients
C. Snopkowski¹, P. Rabbani², H. Yang¹, Z. Berman², G. Diep², C. Li¹, T. Muthukumar¹, R. Ding¹, D. Ceradini², M. Suthanthiran¹
¹Weill Cornell Medical Institute, Department of Medicine, Division of Nephrology, NY, NY, ²NYU Langone Health, Hansjörg Wyss Department of Plastic Surgery, NY, NY
*Purpose: Skin biopsies are currently the gold standard for evaluating the inflammatory status of face allografts. However, “tape stripping” is emerging as a noninvasive technique…
2021 American Transplant Congress
Tacrolimus Dose Requirements in Lung Transplant Recipients on Systemic Azole Antifungals: The Influence of Race and Transplant Indication
K. S. Walter¹, T. Wert¹, R. Coakley², L. J. Lobo², R. A. Evans¹
¹Department of Pharmacy, University of North Carolina, Chapel Hill, NC, ²Department of Medicine, University of North Carolina, Chapel Hill, NC
*Purpose: CYP3A5 polymorphisms, drug interactions, and alterations in gastric absorption impact tacrolimus metabolism. This is important for those at higher risk of expressing these factors,…
2021 American Transplant Congress
Recovery After Extended Static Cold Storage Preservation Using Subnormothermic Machine Perfusion in VCA
M. Goutard¹, R. J. de Vries¹, A. G. Lellouch¹, E. Lupon¹, C. Pendexter¹, S. N. Tessier¹, M. A. Randolph¹, L. Lantieri², C. L. Cetrulo¹, K. Uygun¹
¹Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children, Boston, MA, ²Hôpital Européen Georges Pompidou, Paris, France
*Purpose: Vascularized composite allografts (VCA) are more sensitive to cold ischemia than solid organ transplants due to the remaining metabolism in skeletal muscle cells. In…