Abstracts Archive - Page 183 of 1683 - ATC Abstracts

2022 American Transplant Congress
Use of Belatacept in Non-Compliant Adolescent Patients
C. McAdams¹, C. Gluck¹, E. Hilmas²
¹Nemours Children's Health, Wilmington, DE, ²Nationwide Children's Hospital, Columbus, OH
*Purpose: Adolescents are at high risk for kidney transplant rejection due to non-compliance. While intravenous (IV) maintenance medications are FDA approved for adults, there is…
2022 American Transplant Congress
Deletion of AIF-1 Promotes Kidney Reparative Macrophages and Prevents Fibrosis
I. Husain, A. Dangi, X. Luo
Duke University School of Medicine, Durham, NC
*Purpose: A major etiology contributing to poor allograft survival is the inevitable ischemic insult it incurs during transplantation. Macrophages are key players in ischemia-reperfusion injury,…
2022 American Transplant Congress
Impact of Target Tacrolimus Levels on BK Polyomavirus DNAemia and Allograft Rejection Among Pediatric Kidney Transplant Recipients
H. Huang¹, P. Winterberg¹, R. George¹, A. Serluco², R. Liverman², I. Yildirim³, R. Garro¹
¹Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, ²Children's Healthcare of Atlanta, Atlanta, GA, ³Yale University School of Medicine, New Haven, CT
*Purpose: BK Polyomavirus (BK) DNAemia is a serious and common infectious complication after kidney transplant (KT). We evaluated the impact of targeting lower tacrolimus levels…
2022 American Transplant Congress
National Attitudes Towards Early Liver Transplantation for Alcoholic Liver Disease
J. Mitchell¹, K. Nijhar¹, K. Herrick-Reynolds², H. Sung¹, P. Chen¹, D. L. Segev¹, E. King¹, A. Cameron¹
¹Department Of Surgery, Johns Hopkins University, Baltimore, MD, ²Department Of Surgery, Walter Reed National Military Medical Center, Bethesda, MD
*Purpose: Pre-transplant abstinence requirements, notably the 6-month sobriety guideline, limit access to liver transplant for patients with severe alcoholic hepatitis (SAH). This study examines the…
2022 American Transplant Congress
The Impact of Early Graft Infiltrating TCF-1^LowPD-1^HighCD8⁺ T Cells in Delayed Fc Nonbinding Anti-CD3 Antibody Protocol in the Sensitized Mouse Model
T. Ota¹, R. Goto¹, T. Harada¹, Y. Ganchiku¹, M. Zaitsu¹, A. Forgioni¹, N. Kawamura², M. Watanabe², M. Fukai¹, T. Shimamura³, A. Taketomi¹
¹Dept. of Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan, ²Dept. of Transplant Surgery, Hokkaido University, Sapporo, Japan, ³Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan
*Purpose: Fc nonbinding anti(a)-CD3 antibody has a unique effect that delayed treatment protocol induces a transplant tolerance. Delayed protocol allows early graft infiltrating cells which…
2022 American Transplant Congress
Inhibition of ITGB5 Protects Hepatocytes from Ischemia Reperfusion Injury
M. Dogan¹, S. Naik¹, C. Watkins¹, A. Bajwa¹, V. Mas², J. Eason³, C. Kuscu¹, C. Kuscu¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²Surgery, University of Maryland, Baltimore, MD, ³University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: Liver transplantation is the best treatment option for patients with end-stage liver disease (ESLD). Despite the increasing interest to the machine reperfusion, cold preservation…
2022 American Transplant Congress
Enhancing Early Nerve Regeneration from Reconstruction of a Segmental Nerve Injury with Polyethylene Glycol
A. Bernal¹, C. Hinshaw¹, J. Hinshaw¹, C. Yang², S. Margaux¹, W. Zhang¹, J. Nuelle¹, C. Sabbag¹, G. Bittner², J. Shores³, E. Weitzel¹, J. Alderete¹
¹RESTOR FUSE Nerve Reconstruction Consortium, US Army Institute of Surgical Research/59th MDW, San Antonio, TX, ²University of Texas at Austin, Austin, TX, ³John Hopkins University, Baltimore, MD
*Purpose: Despite advancements in understanding and treating peripheral nerve injuries (PNIs), restoration of lost motor and sensory functions remain poor using current methods of clinical…
2022 American Transplant Congress
Gene Expression Changes Including Long Non-Coding RNAs in Human Hepatic Ischemia Reperfusion Injury
C. Kuscu¹, S. Naik¹, C. Eymard², H. Ingram¹, A. Bajwa¹, D. Maluf³, V. Mas⁴, J. Eason⁵, C. Kuscu¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ³Surgery, University of Maryland, Baltimore, MD, ⁴University of Maryland, Baltimore, MD, ⁵University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: Ischemia reperfusion injury (IRI) is still one of the major problems in liver transplantation affecting long term outcomes. This study is sought out to…
2022 American Transplant Congress
Liver Transplantation for Primary Sclerosing Cholangitis (psc): Experience from the Last Three Decades
J. Zhu¹, D. Lim¹, L. James¹, E. Yoshida², K. Peltekian¹
¹Medicine, Dalhousie University, Halifax, NS, Canada, ²Medicine, University of British Columbia, Vancouver, BC, Canada
*Purpose: In liver transplantation (LT) for PSC, pre-transplant colectomy may lower the risk of PSC recurrence (rPSC), and well-controlled or lack of IBD may protect…
2022 American Transplant Congress
Superoxide in Cardiac Allografts from Donors After Circulatory Death
M. Urban¹, T. Bruett², K. F. Duncan¹, N. W. Markin³, M. M. Chacon³, M. C. Zimmerman⁴
¹Department of Surgery. Division of Cardiothoracic Surgery, University of Nebraska Medical Center, Omaha, NE, ²College of Medicine. Department of Cellular and Integtrative Physiology., University of Nebraska Medical Center, Omaha, NE, ³Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE
*Purpose: Quality of cardiac allografts from donors after circulatory death (DCD) is adversely impacted by warm ischemia and subsequent reperfusion during organ resuscitation. Post-transplant myocardial…