Abstracts Archive - Page 178 of 1683 - ATC Abstracts

2022 American Transplant Congress
Single Cell RNAseq Analysis of Liver Transplant Rejection Reveals Highly Restricted TCR Clonal Expansion of Tissue-Resident Memory CD8⁺ T Cells That Persist Despite Corticosteroids and ATG Therapy
A. L. Peters¹, G. Begum¹, K. Roskin², E. Woodle³, D. Hildeman⁴
¹Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Department of Bioinformatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Department of Surgery, University of Cincinnati, Cincinnati, OH, ⁴Department of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: Conventional therapy for liver transplant rejection (corticosteroids and ATG) has remained unchanged for six decades, and is not infrequently met with treatment failure. Here,…
2022 American Transplant Congress
Gsk3beta Regulates the Resolution of Liver Ischemia Reperfusion Injury via MerTK
H. Zhang¹, M. Ni², J. Zhang¹, R. Busuttil¹, J. Kupiec-Weglinski¹, W. Li³, X. Wang², Y. E. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ³China-Japan Union Hospital of Jilin University, JiLing, China
*Purpose: We have shown previously that glycogen synthase kinase β (Gsk3β) regulates liver inflammatory activation against ischemia/reperfusion injury (IRI). The question of whether it also…
2022 American Transplant Congress
Clusterin Protects Kidney Transplants from Ischemia-Reperfusion Injury by Modulating Neutrophil Infiltration
Y. Shim¹, R. Fan², N. Dvorina², K. McCrae¹, B. William²
¹Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, ²Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH
*Purpose: Ischemia-reperfusion injury (IRI) is inevitable during organ transplantation. Clusterin (CLU) has shown to be protective in IRI. Supplementation of storage solution with recombinant CLU…
2022 American Transplant Congress
Development of Diagnostic Algorithms for Peri-Operative Error Cause and Effect Analysis in Renal Transplant Surgery
P. Gogalniceanu¹, H. Maple¹, G. Papadakis¹, P. Chandak¹, I. Loukopoulos¹, J. Olsburgh¹, N. Kessaris¹, F. Calder¹, N. Sevdalis², N. Mamode¹
¹Guy's and St.Thomas' NHS Foundation Trust, London, United Kingdom, ²King's College London, London, United Kingdom
*Purpose: Peri-operative safety metadata in transplant surgery remain limited. Lack of standardisation and limited models of failure analysis, as well as non-intuitive error taxonomies, deter…
2022 American Transplant Congress
Risk Factors for Micafungin Non-Susceptible Invasive Candidiasis in Solid Organ Transplant Recipients
U. Dhal, J. Morillas-Rodriguez, K. D. Brizendine
Cleveland Clinic, Cleveland, OH
*Purpose: Determine risk factors associated with micafungin non-susceptible invasive candidiasis (IC) in solid organ transplant (SOT) recipients*Methods: We conducted a retrospective study of SOT patients…
2022 American Transplant Congress
Long-Term Outcomes in Living-Donor Preemptive Kidney Transplants: Results from a Brazilian Single-Center Cohort Study
B. Beraldo, L. R. Requião-Moura, M. Gaspar, R. D. Foresto, H. Tedesco-Silva, J. Medina-Pestana
Nephrology Division - Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil
*Purpose: To evaluate predictors of long-term graft function and unfavorable outcomes in living-donor preemptive kidney transplant recipients.*Methods: A single-center cohort study enrolled 223 living-donor preemptive…
2022 American Transplant Congress
Bone Fractures Are Not Increased in Older Prior Living Kidney Donors
H. Amer¹, H. Maradit Kremers¹, D. Larson¹, I. Zaniletti¹, W. K. Kremers¹, A. Matas², B. Kasiske³, S. Khosla¹, R. Kumar¹
¹Mayo Clinic, Rochester, MN, ²University of Minnesota, Minneapolis, MN, ³Hennepin County Medical Center, Minneapolis, MN
*Purpose: Living kidney donors were shown to have derangements of bone biomarkers resembling those occurring in early chronic kidney disease within 36 months of donation.…
2022 American Transplant Congress
Histologic Predictors of Graft Loss in Early Clinically Indicated Biopsies After Kidney Transplantation
M. Ajaimy¹, V. Hemmige², L. E. Liriano-Ward³, Y. Azzi¹, S. Kapoor⁴, P. Loarte¹, C. Pynadath⁵, A. Colovai¹, E. Akalin⁶
¹Einstein-Montefiore Transplant Center, Bronx, NY, ²Montefiore Medical Center, Bronx, NY, ³Transplant, Montefiore Medical Center, Bronx, NY, ⁴Montefiore Medical Center, New York, NY, ⁵Einstein-Montefiore Transplant Center, Scarsdale, NY, ⁶Albert Einstein College of Medicine, Montefiore Medical Ctr, Bronx, NY
*Purpose: We aimed to investigate histopathological predictors of graft lost in patients who underwent clinically indicated biopsies for worsening kidney function and/or proteinuria within 3…
2022 American Transplant Congress
Reducing Financial Burden for Living Donors: A Single Center Experience of Increased National Living Donor Assistance Center (NLDAC) Support
T. Klair, K. Throgmorton, D. Oviedo, E. Cepeda
Transplant Center, University of Texas Health San Antonio, San Antonio, TX
*Purpose: National Living Donor Assistance Center (NLDAC) offers assistance to overcome some of the financial barriers associated with Living Donation. From 2015 to 2020, an…
2022 American Transplant Congress
Telemedical Surveillance and Optimized Treatment of Blood Pressure in Kidney Transplant Recipients
W. Düttmann¹, M. G. Naik¹, B. Zukunft¹, B. Osmanodja¹, G. Eleftheriadis¹, S. Ronicke², M. Choi¹, F. Bachmann¹, F. Halleck¹, K. Budde¹
¹Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany
*Purpose: Patients with chronic kidney disease suffer often from cardiovascular diseases, especially high blood pressure and its complications such as stroke and heart attack. After…